{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:51:54Z","timestamp":1787503914583,"version":"build-2736575974"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,23]]},"DOI":"10.7759\/cureus.99934","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T14:47:12Z","timestamp":1766501232000},"source":"Crossref","is-referenced-by-count":2,"title":["Whipple\u2019s Disease, a Rare Cause of Constrictive Myopericarditis and Right-Sided Heart Failure"],"prefix":"10.7759","author":[{"given":"Juliette","family":"Marot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Pierard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Bamps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halil","family":"Yildiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Cyr","family":"Yombi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","article-title":"A hitherto undescribed disease characterized anatomically by deposits of fat and fatty acids in the intestinal and mesenteric lymphatic tissues","volume":"111","author":"Whipple GH","year":"1962","unstructured":"Whipple GH. A hitherto undescribed disease characterized anatomically by deposits of fat and fatty acids in the intestinal and mesenteric lymphatic tissues. Bull Johns Hopkins Hosp. 1962, 111:17-36.","journal-title":"Bull Johns Hopkins Hosp"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199207303270501","article-title":"Identification of the uncultured bacillus of Whipple's disease","volume":"327","author":"Relman DA","year":"1992","unstructured":"Relman DA, Schmidt TM, MacDermott RP, Falkow S. Identification of the uncultured bacillus of Whipple's disease. N Engl J Med. 1992, 327:293-301. 10.1056\/NEJM199207303270501","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2014.05.008","article-title":"Tropheryma whipplei and Whipple's disease","volume":"69","author":"Fenollar F","year":"2014","unstructured":"Fenollar F, Lagier JC, Raoult D. Tropheryma whipplei and Whipple's disease. J Infect. 2014, 69:103-12. 10.1016\/j.jinf.2014.05.008","journal-title":"J Infect"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2017.01.048","article-title":"Whipple's disease","volume":"377","author":"El-Abassi R","year":"2017","unstructured":"El-Abassi R, Soliman MY, Williams F, England JD. Whipple's disease. J Neurol Sci. 2017, 377:197-206. 10.1016\/j.jns.2017.01.048","journal-title":"J Neurol Sci"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-72-17388","article-title":"The tinctoral demonstration of a glycoprotein in Whipple's disease","volume":"72","author":"Black-Schaffer B","year":"1949","unstructured":"Black-Schaffer B. The tinctoral demonstration of a glycoprotein in Whipple's disease. Proc Soc Exp Biol Med. 1949, 72:225-7. 10.3181\/00379727-72-17388","journal-title":"Proc Soc Exp Biol Med"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12274-X","article-title":"Whipple\u2019s disease","volume":"361","author":"Marth T","year":"2003","unstructured":"Marth T, Raoult D. Whipple\u2019s disease. Lancet. 2003, 361:239-46. 10.1016\/S0140-6736(03)12274-X","journal-title":"Lancet"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-13-579","article-title":"Constrictive pleuropericarditis: a dominant clinical manifestation in Whipple's disease","volume":"13","author":"Stojan G","year":"2013","unstructured":"Stojan G, Melia MT, Khandhar SJ, Illei P, Baer AN. Constrictive pleuropericarditis: a dominant clinical manifestation in Whipple's disease. BMC Infect Dis. 2013, 13:579. 10.1186\/1471-2334-13-579","journal-title":"BMC Infect Dis"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-7-48","article-title":"False positive PCR detection of Tropheryma whipplei in the saliva of healthy people","volume":"7","author":"Rolain JM","year":"2007","unstructured":"Rolain JM, Fenollar F, Raoult D. False positive PCR detection of Tropheryma whipplei in the saliva of healthy people. BMC Microbiol. 2007, 7:48. 10.1186\/1471-2180-7-48","journal-title":"BMC Microbiol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/pmj.76.902.760","article-title":"Whipple's disease","volume":"76","author":"Ratnaike RN","year":"2000","unstructured":"Ratnaike RN. Whipple's disease. Postgrad Med J. 2000, 76:760-6. 10.1136\/pmj.76.902.760","journal-title":"Postgrad Med J"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(73)90264-7","article-title":"Whipple\u2019s disease presenting as pleuropericarditis","volume":"55","author":"Pastor BM","year":"1973","unstructured":"Pastor BM, Green R. Whipple\u2019s disease presenting as pleuropericarditis. Am J Med. 1973, 55:731-6. 10.1016\/0002-9343(73)90264-7","journal-title":"Am J Med"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.09.084","article-title":"All in the farm: an unusual case of endocarditis and pericarditis","volume":"63","author":"Lahoud R","year":"2014","unstructured":"Lahoud R, Kwon DH, Tan CD, Klein AL. All in the farm: an unusual case of endocarditis and pericarditis. J Am Coll Cardiol. 2014, 63:e19. 10.1016\/j.jacc.2013.09.084","journal-title":"J Am Coll Cardiol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.52.1.152","article-title":"Cardiac involvement in Whipple's disease","volume":"52","author":"McAllister HA Jr","year":"1975","unstructured":"McAllister HA Jr, Fenoglio JJ Jr. Cardiac involvement in Whipple's disease. Circulation. 1975, 52:152-6. 10.1161\/01.cir.52.1.152","journal-title":"Circulation"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcs041","article-title":"A constricting differential--a case of severe anaemia, weight loss and pericarditis due to Tropheryma whipplei infection","volume":"107","author":"Sutherland RK","year":"2014","unstructured":"Sutherland RK, Russell KV, Trivedi PJ, Warren B, Smith RW, Conlon CP. A constricting differential--a case of severe anaemia, weight loss and pericarditis due to Tropheryma whipplei infection. QJM. 2014, 107:927-9. 10.1093\/qjmed\/hcs041","journal-title":"QJM"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-019-1257-2","article-title":"Another Whipple's triad? Pericardial, myocardial and valvular disease in an unusual case presentation from a Canadian perspective","volume":"19","author":"Thornton CS","year":"2019","unstructured":"Thornton CS, Wang Y, K\u00f6ebel M, et al.. Another Whipple's triad? Pericardial, myocardial and valvular disease in an unusual case presentation from a Canadian perspective. BMC Cardiovasc Disord. 2019, 19:312. 10.1186\/s12872-019-1257-2","journal-title":"BMC Cardiovasc Disord"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(22)00128-1","article-title":"Whipple\u2019s disease and Tropheryma whipplei infections: from bench to bedside","volume":"22","author":"Boumaza A","year":"2022","unstructured":"Boumaza A, Ben Azzouz E, Arrindell J, and al.. Whipple\u2019s disease and Tropheryma whipplei infections: from bench to bedside. Lancet Infect Dis. 2022, 22:280-91. 10.1016\/S1473-3099(22)00128-1","journal-title":"Lancet Infect Dis"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0828-282X(09)70051-0","article-title":"Whipple\u2019s disease with constrictive pericarditis: a rare disease with a rare presentation","volume":"25","author":"Iqbal T","year":"2009","unstructured":"Iqbal T, Karovitch A, Veinot J, and al. Whipple\u2019s disease with constrictive pericarditis: a rare disease with a rare presentation. Can J Cardiol. 2009, 25:86-8. 10.1016\/S0828-282X(09)70051-0","journal-title":"Can J Cardiol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.1978.tb04857.x","article-title":"Whipple's disease involving the pericardium: Pathological confirmation during life","volume":"8","author":"Vlietstra RE","year":"1978","unstructured":"Vlietstra RE, Lie JT, Kuhl WE, Danielson GK, Roberts MK. Whipple's disease involving the pericardium: Pathological confirmation during life. Aust N Z J Med. 1978, 8:649-51. 10.1111\/j.1445-5994.1978.tb04857.x","journal-title":"Aust N Z J Med"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.59.689.194","article-title":"Constrictive pericarditis and intestinal haemorrhage due to Whipple's disease","volume":"59","author":"Crake T","year":"1983","unstructured":"Crake T, Sandle GI, Crisp AJ, Record CO. Constrictive pericarditis and intestinal haemorrhage due to Whipple's disease. Postgrad Med J. 1983, 59:194-5. 10.1136\/pgmj.59.689.194","journal-title":"Postgrad Med J"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00292-022-01170-5","article-title":"Massive pancarditis-autopsy report (Article in German)","volume":"44","author":"Hansen T","year":"2023","unstructured":"Hansen T, Otto M, Pohl J, Birkner G, Hansen I, Titze U, Kriegsmann J. Massive pancarditis-autopsy report (Article in German). Pathologie (Heidelb). 2023, 44:132-8. 10.1007\/s00292-022-01170-5","journal-title":"Pathologie (Heidelb)"},{"key":"ref20","article-title":"Constrictive pericarditis and Whipple's disease (Article in French)","volume":"83","author":"Freychet L","year":"1990","unstructured":"Freychet L, Duboc D, Gu\u00e9rin F, Chomette G. Constrictive pericarditis and Whipple's disease (Article in French). Arch Mal Coeur Vaiss. 1990, 83:1729-32.","journal-title":"Arch Mal Coeur Vaiss"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmal.2014.06.002","article-title":"A case of Whipple's disease evolving over 30 years","volume":"44","author":"Lochouarn M","year":"2014","unstructured":"Lochouarn M, Lagier JC, Raoult D, Pulcini C. A case of Whipple's disease evolving over 30 years. Med Mal Infect. 2014, 44:331-3. 10.1016\/j.medmal.2014.06.002","journal-title":"Med Mal Infect"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21645","article-title":"A case of refractory rheumatoid pericarditis","volume":"64","author":"Makol A","year":"2012","unstructured":"Makol A, Maleszewski JJ, Warrington KJ. A case of refractory rheumatoid pericarditis. Arthritis Care Res (Hoboken). 2012, 64:935-40. 10.1002\/acr.21645","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/66.1.22","article-title":"Pancarditis in Whipple's disease: electronmicroscopic demonstration of intracardiac bacillary bodies","volume":"66","author":"Lie JT","year":"1976","unstructured":"Lie JT, Davis JS. Pancarditis in Whipple's disease: electronmicroscopic demonstration of intracardiac bacillary bodies. Am J Clin Pathol. 1976, 66:22-30. 10.1093\/ajcp\/66.1.22","journal-title":"Am J Clin Pathol"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00537-X","article-title":"Tropheryma whipplei infection and Whipple\u2019s disease","volume":"16","author":"Marth T","year":"2016","unstructured":"Marth T, Moos V, M\u00fcller C, and al.. Tropheryma whipplei infection and Whipple\u2019s disease. Lancet Infect Dis. 2016, 16:13-22. 10.1016\/S1473-3099(15)00537-X","journal-title":"Lancet Infect Dis"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcha.2023.101221","article-title":"High-risk and low prevalence disease: cardiac sarcoidosis and some of its mimics","volume":"47","author":"Jolobe OM","year":"2023","unstructured":"Jolobe OM. High-risk and low prevalence disease: cardiac sarcoidosis and some of its mimics. Int J Cardiol Heart Vasc. 2023, 47:101221. 10.1016\/j.ijcha.2023.101221","journal-title":"Int J Cardiol Heart Vasc"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(24)00797-7","article-title":"Oral treatment of Whipple\u2019s disease with doxycycline and hydroxychloroquine versus intravenous therapy with ceftriaxone followed by oral trimethoprim-sulfamethoxazole: a randomized non-inferiority trial","volume":"25","author":"Moos V","year":"2025","unstructured":"Moos V, Kr\u00fcger J, Allers K, et al.. Oral treatment of Whipple\u2019s disease with doxycycline and hydroxychloroquine versus intravenous therapy with ceftriaxone followed by oral trimethoprim-sulfamethoxazole: a randomized non-inferiority trial. Lancet Infect Dis. 2025, 25:788-800. 10.1016\/S1473-3099(24)00797-7","journal-title":"Lancet Infect Dis"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1265414","article-title":"Current knowledge of the immune reconstitution inflammatory syndrome in Whipple disease: a review","volume":"14","author":"Song X","year":"2023","unstructured":"Song X, Duan R, Duan L, Wei L. Current knowledge of the immune reconstitution inflammatory syndrome in Whipple disease: a review. Front Immunol. 2023, 14:1265414. 10.3389\/fimmu.2023.1265414","journal-title":"Front Immunol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/440119-whipples-disease-a-rare-cause-of-constrictive-myopericarditis-and-right-sided-heart-failure","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T14:47:13Z","timestamp":1766501233000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/440119-whipples-disease-a-rare-cause-of-constrictive-myopericarditis-and-right-sided-heart-failure"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,23]]},"references-count":27,"URL":"https:\/\/doi.org\/10.7759\/cureus.99934","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12,23]]}}}