{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:04:44Z","timestamp":1762506284339,"version":"3.38.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technol Cancer Res Treat"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:p> Currently, the most common method of delivering intensity-modulated radiotherapy (IMRT) is through step-and-shoot, segmental multi-leaf collimator (SMLC)-based techniques. Although rotational delivery methods such as helical tomotherapy (HT) have been proposed as offering advantages in the treatment of head and neck cancer, a lack of clinical data exists on its potential utility. This study compared dosimetric, clinical, and quality-of-life endpoints among 149 patients treated by HT and SMLC-IMRT for head and neck cancer. Dosimetric analysis revealed that the use of HT resulted in significant improvements with respect to mean dose (23.5 versus 27.9 Gy, p = 0.03) and V30 (30.1 versus 43.9 Gy, p = 0.01) to the contralateral (spared) parotid gland. However, the incidence of grade 3+ xerostomia in the late setting was 10% and 8% among patients treated by HT and SMLC-IMRT, respectively (p = 0.46). There were no significant differences in any of the quality of life endpoints among patients treated by HT and SMLC-IMRT (p &gt; 0.05, for all). Acknowledging the biases inherent in this retrospective analysis, we found that the dosimetric advantages observed with HT compared to SMLC-IMRT failed to translate into significant improvements in clinical outcome. Prospective studies are needed to further evaluate how HT may affect the therapeutic ratio. <\/jats:p>","DOI":"10.7785\/tcrt.2012.500192","type":"journal-article","created":{"date-parts":[[2014,3,13]],"date-time":"2014-03-13T20:11:20Z","timestamp":1394741480000},"page":"171-177","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Comparison of IMRT Techniques in the Radiotherapeutic Management of Head and Neck Cancer: Is Tomotherapy \u201cBetter\u201d than Step-and-Shoot IMRT?"],"prefix":"10.1177","volume":"10","author":[{"given":"A. M.","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, University of California Davis Cancer Center, 4501 X Street, Suite G140 Sacramento, CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Marsano","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of California Davis Cancer Center, 4501 X Street, Suite G140 Sacramento, CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Perks","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of California Davis Cancer Center, 4501 X Street, Suite G140 Sacramento, CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Farwell","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, University of California Davis Cancer Center, 4501 X Street, Suite G140 Sacramento, CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.","family":"Luu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, University of California Davis Cancer Center, 4501 X Street, Suite G140 Sacramento, CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. J.","family":"Donald","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, University of California Davis Cancer Center, 4501 X Street, Suite G140 Sacramento, CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A.","family":"Purdy","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of California Davis Cancer Center, 4501 X Street, Suite G140 Sacramento, CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,4,1]]},"reference":[{"key":"bibr1-tcrt.2012.500192","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(03)00405-X"},{"key":"bibr2-tcrt.2012.500192","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.13.4874"},{"key":"bibr3-tcrt.2012.500192","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.02.045"},{"key":"bibr4-tcrt.2012.500192","doi-asserted-by":"publisher","DOI":"10.1016\/S0958-3947(02)00090-0"},{"key":"bibr5-tcrt.2012.500192","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.02.038"},{"key":"bibr6-tcrt.2012.500192","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.04.011"},{"key":"bibr7-tcrt.2012.500192","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2006.02.009"},{"key":"bibr8-tcrt.2012.500192","doi-asserted-by":"publisher","DOI":"10.1177\/153303461000900308"},{"key":"bibr9-tcrt.2012.500192","doi-asserted-by":"publisher","DOI":"10.1118\/1.2890085"},{"key":"bibr10-tcrt.2012.500192","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3656-4"},{"key":"bibr11-tcrt.2012.500192","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(95)00060-C"},{"key":"bibr12-tcrt.2012.500192","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"bibr13-tcrt.2012.500192","doi-asserted-by":"publisher","DOI":"10.1118\/1.1639148"},{"key":"bibr14-tcrt.2012.500192","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-4296(99)80058-7"},{"key":"bibr15-tcrt.2012.500192","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.5501"},{"key":"bibr16-tcrt.2012.500192","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.04.048"},{"key":"bibr17-tcrt.2012.500192","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.05.002"},{"key":"bibr18-tcrt.2012.500192","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.06.090"},{"key":"bibr19-tcrt.2012.500192","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(99)00247-3"},{"key":"bibr20-tcrt.2012.500192","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.04.021"},{"key":"bibr21-tcrt.2012.500192","first-page":"215","volume":"5","author":"Brosky M. 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