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The objective of this work is to improve the classification accuracy based on textural features for the development of a computer assisted screening of oral sub-mucous fibrosis (OSF). In fact, the approach introduced is used to grade the histopathological tissue sections into normal, OSF without dysplasia (OSFWD) and OSF with dysplasia (OSFD), which would help the oral onco-pathologists to screen the subjects rapidly. The main objective of this work is to evaluate the use of Higher Order Spectra (HOS) features and Local Binary Pattern (LBP) features extracted from the epithelial layer in classifying normal, OSFWD and OSFD. For this purpose, we extracted twenty three HOS features and nine LBP features and fed them to a Support Vector Machine (SVM) for automated diagnosis. One hundred and fifty eight images (90 normal, 42 OSFWD and 26 OSFD images) were used for analysis. LBP features provide a good sensitivity of 82.85% and specificity of 87.84%, and the HOS features provide higher values of sensitivity (94.07%) and specificity (93.33%) using SVM classifier. The proposed system, can be used as an adjunct tool by the onco-pathologists to cross-check their diagnosis. <\/jats:p>","DOI":"10.7785\/tcrt.2012.500221","type":"journal-article","created":{"date-parts":[[2013,12,2]],"date-time":"2013-12-02T20:49:43Z","timestamp":1386017383000},"page":"443-455","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":35,"title":["Automated Diagnosis of Oral Cancer Using Higher Order Spectra Features and Local Binary Pattern: A Comparative Study"],"prefix":"10.1177","volume":"10","author":[{"given":"M. M. 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