{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:53:27Z","timestamp":1761155607232,"version":"3.38.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technol Cancer Res Treat"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p> Purpose of this study is to evaluate radiographic therapy response, clinical outcome and adverse effects of CyberKnife radiosurgery in patients suffering from orbital metastases. Sixteen orbital metastases originating from different solid cancers in fourteen patients were treated by single fraction CyberKnife radiosurgery. Radiographic response and clinical outcome were evaluated. The treated tumor volume ranged from 0.2 to 35 cm<jats:sup>3<\/jats:sup> (median 2.3 cm<jats:sup>3<\/jats:sup>, mean 7.0 cm<jats:sup>3<\/jats:sup>, SD \u00b1 10.4 cm<jats:sup>3<\/jats:sup>, CI 0.9\u20139.4 cm<jats:sup>3<\/jats:sup>). The prescription dose ranged from 16.5\u201321 Gy (median 18 Gy, mean 18.2 Gy, SD \u00b1 1.2 Gy, CI 17.0\u201318.4 Gy). A no change situation was observed in nine lesions, partial remission in four as well as complete remission in one metastasis. Tumor growth was stabilized or regressive following CyberKnife therapy in 87% of the cases. Recurrence was observed in two cases (13%). Before therapy, three patients suffered from visual disturbance and five patients reported diplopia. Six patients had no initial symptoms. After therapy, one patient indicated improvement of the present visual deficit and two patients no change. Out of the two patients with persistent diplopia, two reported improvement after therapy and three no change. No progression of symptoms was noted in any of the cases. Fourteen out of sixteen treated lesions were stable or regressive following CyberKnife radiosurgery (87%). As no serious adverse effects were reported in this series, CyberKnife therapy was shown to be of great value for local management of orbital metastases. <\/jats:p>","DOI":"10.7785\/tcrt.2012.500257","type":"journal-article","created":{"date-parts":[[2012,7,31]],"date-time":"2012-07-31T17:34:36Z","timestamp":1343756076000},"page":"433-439","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["CyberKnife Radiosurgery for the Treatment of Orbital Metastases"],"prefix":"10.1177","volume":"11","author":[{"given":"A.","family":"Klingenstein","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Ludwig-Maximilians-University, Klinikum der Universit\u00e4t M\u00fcnchen, Campus Innenstadt, Mathildenstra\u00dfe 8, D-80336 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kufeld","sequence":"additional","affiliation":[{"name":"European CyberKnife Center, Max-Lebsche-Platz 31, D-81377 M\u00fcnchen Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Wowra","sequence":"additional","affiliation":[{"name":"European CyberKnife Center, Max-Lebsche-Platz 31, D-81377 M\u00fcnchen Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Muacevic","sequence":"additional","affiliation":[{"name":"European CyberKnife Center, Max-Lebsche-Platz 31, D-81377 M\u00fcnchen Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"F\u00fcrweger","sequence":"additional","affiliation":[{"name":"European CyberKnife Center, Max-Lebsche-Platz 31, D-81377 M\u00fcnchen Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U. C.","family":"Schaller","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ludwig-Maximilians-University, Klinikum der Universit\u00e4t M\u00fcnchen, Campus Innenstadt, Mathildenstra\u00dfe 8, D-80336 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,10,1]]},"reference":[{"key":"bibr1-tcrt.2012.500257","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(90)90045-W"},{"key":"bibr2-tcrt.2012.500257","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-55910-5_10"},{"key":"bibr3-tcrt.2012.500257","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1987.01060090073031"},{"key":"bibr4-tcrt.2012.500257","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2008.02.003"},{"key":"bibr5-tcrt.2012.500257","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4160-3167-3.50101-7"},{"key":"bibr6-tcrt.2012.500257","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.3.1244"},{"key":"bibr7-tcrt.2012.500257","doi-asserted-by":"publisher","DOI":"10.1097\/00002341-200109000-00009"},{"key":"bibr8-tcrt.2012.500257","doi-asserted-by":"publisher","DOI":"10.1177\/153303460800700503"},{"key":"bibr9-tcrt.2012.500257","doi-asserted-by":"publisher","DOI":"10.3171\/FOC-07\/12\/E11"},{"key":"bibr10-tcrt.2012.500257","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2010.283"},{"key":"bibr11-tcrt.2012.500257","doi-asserted-by":"publisher","DOI":"10.1016\/j.surneu.2006.08.002"},{"key":"bibr12-tcrt.2012.500257","doi-asserted-by":"publisher","DOI":"10.1159\/000099863"},{"issue":"6","key":"bibr13-tcrt.2012.500257","first-page":"1299","volume":"44","author":"Adler J. 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