{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T04:19:46Z","timestamp":1741666786883,"version":"3.38.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technol Cancer Res Treat"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p> Chemo-radiotherapy is standard treatment of stage IIIA-N2 bulky or IIIB non-small cell lung cancer (NSCLC). Surgical resection of residual disease in downstaged patients may improve overall survival. In this setting, restaging disease is still a challenge. 18F-FDG PET\/CT represents the gold standard although accuracy results are disappointing. Endoscopic bronchial\/ esophageal ultrasound (EBUS\/EUS)-guided fine needle aspiration (FNA) may confirm lymph node (LN) involvement. We analyzed 16 patients with stage IIIA-N2 bulky or IIIB NSCLC treated with chemo-radiotherapy. At restaging, all patients performed EBUS\/EUS with FNA and PET\/CT scan and results were compared. Patients underwent PET\/CT scan 43 days (range: 24-89) and EBUS\/EUS 42 days (range: 14-71) after therapy. Overall, 7 EBUS and 9 EUS procedures were performed: no complications resulting from the procedure occurred. In 6 patients EBUS\/EUS did not reveal any suspicious lesions; in 2 the exam showed enlarged mediastinal LN that were biopsied, but with no evidence of tumor cells; in 2 the sample was not considered diagnostic; 6 had persistent mediastinal LN involvement. PET\/CT scan showed 4 cases of complete metabolic response, 9 partial metabolic response, 2 stable metabolic disease and one progressive metabolic disease. Notably, all 7 patients with .80% decrease in SUV with respect to basal value showed a pathological complete response or negative EBUS\/EUS. EBUS\/EUS could be used to complement PET\/CT scanning to verify mediastinal LN clearance. Further prospective trials are warranted to confirm the utility of EBUS\/EUS together with PET\/CT in restaging locally advanced NSCLC. <\/jats:p>","DOI":"10.7785\/tcrt.2012.500437","type":"journal-article","created":{"date-parts":[[2014,6,18]],"date-time":"2014-06-18T20:55:47Z","timestamp":1403124947000},"page":"721-727","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Endobronchial\/Endoesophageal Ultrasound (EBUS\/EUS) Guided Fine Needle Aspiration (FNA) and <sup>18<\/sup>F-FDG PET\/CT Scanning in Restaging of Locally Advanced Non-small Cell Lung Cancer (NSCLC) Treated with Chemo-radiotherapy"],"prefix":"10.1177","volume":"14","author":[{"given":"Giovenzio","family":"Genestreti","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, AUSL Rimini, \u201cCervesi\u201d Hospital, Cattolica, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco Angelo","family":"Burgio","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Matteucci","sequence":"additional","affiliation":[{"name":"Diagnostic Nuclear Medicine Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Piciucchi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Morgagni-Pierantoni Hospital, Forl\u00ec, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Scarpi","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics and Clinical Trials, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Monti","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics and Clinical Trials, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauro","family":"Bucchi","sequence":"additional","affiliation":[{"name":"Romagna Cancer Registry, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Parisi","sequence":"additional","affiliation":[{"name":"Radiotherapy Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Crociani","sequence":"additional","affiliation":[{"name":"Department of Pneumology, Morgagni-Pierantoni Hospital, Forl\u00ec, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Gurioli","sequence":"additional","affiliation":[{"name":"Department of Pneumology, Morgagni-Pierantoni Hospital, Forl\u00ec, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venerino","family":"Poletti","sequence":"additional","affiliation":[{"name":"Department of Pneumology, Morgagni-Pierantoni Hospital, Forl\u00ec, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giampaolo","family":"Gavelli","sequence":"additional","affiliation":[{"name":"Radiology Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,1,1]]},"container-title":["Technology in Cancer Research &amp; Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.7785\/tcrt.2012.500437","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.7785\/tcrt.2012.500437","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T14:47:12Z","timestamp":1741618032000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.7785\/tcrt.2012.500437"}},"subtitle":["A Mono-institutional Pilot Experience"],"short-title":[],"issued":{"date-parts":[[2014,1,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.7785\/tcrt.2012.500437"],"URL":"https:\/\/doi.org\/10.7785\/tcrt.2012.500437","relation":{},"ISSN":["1533-0346","1533-0338"],"issn-type":[{"type":"print","value":"1533-0346"},{"type":"electronic","value":"1533-0338"}],"subject":[],"published":{"date-parts":[[2014,1,1]]}}}