{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T19:01:44Z","timestamp":1772564504312,"version":"3.50.1"},"reference-count":10,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T00:00:00Z","timestamp":1712534400000},"content-version":"vor","delay-in-days":1254,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Medicine"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.7861\/clinmed.2020-0661","type":"journal-article","created":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T09:06:04Z","timestamp":1605517564000},"page":"e264-e266","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Lessons of the month: A breathless severe asthmatic in the genomic era: Occam's razor or Hickam's dictum?"],"prefix":"10.1016","volume":"20","author":[{"given":"Carmen","family":"Venegas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Svenningsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Kjarsgaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Tarnopolsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Levesque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin A","family":"Raby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace","family":"Parraga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard","family":"Cox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parameswaran","family":"Nair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.7861\/clinmed.2020-0661_bib1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1136\/thoraxjnl-2013-203711","article-title":"What are ventilation defects in asthma","volume":"69","author":"Svenningsen","year":"2014","journal-title":"Thorax"},{"key":"10.7861\/clinmed.2020-0661_bib2","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1056\/NEJMoa064707","article-title":"Asthma control during the year after bronchial thermoplasty","volume":"356","author":"Cox","year":"2007","journal-title":"N Engl J Med"},{"key":"10.7861\/clinmed.2020-0661_bib3","first-page":"143","article-title":"Optimizing sputum cell counts prior to bronchial thermoplasty: A preliminary report","volume":"3","author":"Svenningsen","year":"2019","journal-title":"Can J Respir Crit Care Sleep Med"},{"key":"10.7861\/clinmed.2020-0661_bib4","doi-asserted-by":"crossref","first-page":"e408","DOI":"10.1212\/NXG.0000000000000408","article-title":"Molecular diagnosis of muscular diseases in outpatient clinics: A Canadian perspective","volume":"6","author":"Thuriot","year":"2020","journal-title":"Neurol Genet"},{"key":"10.7861\/clinmed.2020-0661_bib5","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1097\/00005072-199605000-00009","article-title":"Myofibrillar myopathy with abnormal foci of desmin positivity: II. Immunocytochemical analysis reveals accumulation of multiple other proteins","volume":"55","author":"De Bleecker","year":"1996","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.7861\/clinmed.2020-0661_bib6","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00401-012-1054-9","article-title":"Filamin C-related myopathies: pathology and mechanisms","volume":"125","author":"F\u00fcrst","year":"2013","journal-title":"Acta Neuropathol"},{"key":"10.7861\/clinmed.2020-0661_bib7","doi-asserted-by":"crossref","first-page":"e002151","DOI":"10.1161\/CIRCGEN.117.002151","article-title":"Variants in NKX2-5 and FLNC cause dilated cardiomyopathy and sudden cardiac death","volume":"11","author":"Sveinbjornsson","year":"2018","journal-title":"Circ Genom Precis Med"},{"key":"10.7861\/clinmed.2020-0661_bib8","doi-asserted-by":"crossref","first-page":"e001780","DOI":"10.1161\/CIRCGENETICS.117.001780","article-title":"Novel mutation in FLNC (filamin C) causes familial restrictive cardiomyopathy","volume":"10","author":"Tucker","year":"2017","journal-title":"Circ Cardiovasc Genet"},{"key":"10.7861\/clinmed.2020-0661_bib9","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1165\/rcmb.2010-0369OC","article-title":"Expression profiling identifies Klf15 as a glucocorticoid target that regulates airway hyperresponsiveness","volume":"45","author":"Masuno","year":"2011","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.7861\/clinmed.2020-0661_bib10","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1164\/rccm.201905-1021OC","article-title":"Single-session bronchial thermoplasty guided by 129xe magnetic resonance imaging: a pilot randomized clinical trial","volume":"202","author":"Hall","year":"2020","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1470211824034493?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1470211824034493?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.7861\/clinmed.2020-0661","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T06:40:03Z","timestamp":1761460803000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1470211824034493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["S1470211824034493"],"URL":"https:\/\/doi.org\/10.7861\/clinmed.2020-0661","relation":{},"ISSN":["1470-2118"],"issn-type":[{"value":"1470-2118","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lessons of the month: A breathless severe asthmatic in the genomic era: Occam's razor or Hickam's dictum?","name":"articletitle","label":"Article Title"},{"value":"Clinical Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.7861\/clinmed.2020-0661","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 Royal College of Physicians 2020. All rights reserved.","name":"copyright","label":"Copyright"}]}}