{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T05:36:05Z","timestamp":1793597765347,"version":"4.5.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T00:00:00Z","timestamp":1712361600000},"content-version":"vor","delay-in-days":826,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Medicine"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.7861\/clinmed.2021-0791","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T12:10:30Z","timestamp":1643112630000},"page":"9-13","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":232,"title":["Dengue infection: Global importance, immunopathology and management"],"prefix":"10.1016","volume":"22","author":[{"given":"Senanayake Abeysinghe","family":"Kularatne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chamara","family":"Dalugama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.7861\/clinmed.2021-0791_bib1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s40249-021-00908-2","article-title":"Clinical predictors of severe dengue: a systematic review and meta-analysis","volume":"10","author":"Tsheten","year":"2021","journal-title":"Infect Dis Poverty"},{"key":"10.7861\/clinmed.2021-0791_bib2","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1136\/bmj.1.848.382","article-title":"On dengue or dandy fever","volume":"1","author":"Smart","year":"1877","journal-title":"Br Med J"},{"key":"10.7861\/clinmed.2021-0791_bib3","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1139\/cjm-2020-0572","article-title":"Dengue virus: epidemiology, biology, and disease aetiology","volume":"67","author":"Roy","year":"2021","journal-title":"Can J Microbiol"},{"key":"10.7861\/clinmed.2021-0791_bib4","first-page":"1078","article-title":"Global dengue importation: a systematic review","volume":"21","author":"Gwee","year":"2021","journal-title":"BMC Infect Dis"},{"key":"10.7861\/clinmed.2021-0791_bib5","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1086\/343813","article-title":"High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever.","volume":"186","author":"Libraty","year":"2002","journal-title":"J Infect Dis"},{"key":"10.7861\/clinmed.2021-0791_bib6","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1128\/CMR.11.3.480","article-title":"Dengue and dengue hemorrhagic fever","volume":"11","author":"Gubler","year":"1998","journal-title":"Clin Microbiol Rev"},{"key":"10.7861\/clinmed.2021-0791_bib7","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0065-3527(03)60010-2","article-title":"Immunology and immunopathogenesis of dengue disease","volume":"60","author":"Rothman","year":"2003","journal-title":"Adv Virus Res"},{"key":"10.7861\/clinmed.2021-0791_bib8","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.cimid.2007.05.010","article-title":"Dengue hemorrhagic fever with special emphasis on immunopathogenesis","volume":"30","author":"Kurane","year":"2007","journal-title":"Comp Immunol Microbiol Infect Dis"},{"key":"10.7861\/clinmed.2021-0791_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/2231-0762.175416","article-title":"Dengue virus: A global human threat: Review of literature","volume":"6","author":"Hasan","year":"2016","journal-title":"J Int Soc Prev Community Dent"},{"key":"10.7861\/clinmed.2021-0791_bib10","unstructured":"World Health Organization Regional office for South East Asia. Comprehensive guidelines for prevention and control of dengue and dengue haemorrhagic fever, revised and expanded edition. New Delhi: World Health Organization South East Asia regional office, 2011."},{"key":"10.7861\/clinmed.2021-0791_bib11","series-title":"Guidelines on management of dengue fever and dengue haemorrhagic fever in adults","author":"Ministry of Health Sri Lanka, in collaboration with Ceylon College of Physicians","year":"2010"},{"key":"10.7861\/clinmed.2021-0791_bib12","doi-asserted-by":"crossref","first-page":"h4661","DOI":"10.1136\/bmj.h4661","article-title":"Dengue fever","volume":"351","author":"Kularatne","year":"2015","journal-title":"BMJ"},{"key":"10.7861\/clinmed.2021-0791_bib13","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.trstmh.2008.06.001","article-title":"A case series of dengue fever with altered consciousness and electroencephalogram changes in Sri Lanka","volume":"102","author":"Kularatne","year":"2008","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.7861\/clinmed.2021-0791_bib14","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s13256-018-1626-y","article-title":"Dengue fever complicated with Guillain-Barr\u00e9 syndrome: a case report and review of the literature","volume":"12","author":"Dalugama","year":"2018","journal-title":"J Med Case Rep"},{"key":"10.7861\/clinmed.2021-0791_bib15","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/1756-0500-4-268","article-title":"Histopathological diagnosis of myocarditis in a dengue outbreak in Sri Lanka, 2009","volume":"4","author":"Weerakoon","year":"2011","journal-title":"BMC Res Notes"},{"key":"10.7861\/clinmed.2021-0791_bib16","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/1471-2334-14-141","article-title":"Extensive haemorrhagic necrosis of liver is an unpredictable fatal complication in dengue infection: a postmortem study","volume":"14","author":"Kularatne","year":"2014","journal-title":"BMC Infect Dis"},{"key":"10.7861\/clinmed.2021-0791_bib17","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1038\/nrmicro2459","article-title":"Evaluation of diagnostic tests: dengue","volume":"8","author":"Peeling","year":"2010","journal-title":"Nat Rev Microbiol"},{"key":"10.7861\/clinmed.2021-0791_bib18","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/s13256-018-1766-0","article-title":"Lessons learnt from managing a case of dengue hemorrhagic fever complicated with acute liver failure and acute kidney injury: a case report","volume":"12","author":"Dalugama","year":"2018","journal-title":"J Med Case Rep"},{"key":"10.7861\/clinmed.2021-0791_bib19","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.4269\/ajtmh.2007.77.1135","article-title":"Lack of efficacy of high-dose intravenous immunoglobulin treatment of severe thrombocytopenia in patients with secondary dengue virus infection","volume":"77","author":"Dimaano","year":"2007","journal-title":"Am J Trop Med Hyg"},{"key":"10.7861\/clinmed.2021-0791_bib20","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1186\/s12879-021-06681-9","article-title":"Use of intravenous N-acetylcysteine in acute severe hepatitis due to severe dengue infection: a case series","volume":"21","author":"Dissanayake","year":"2021","journal-title":"BMC Infect Dis"},{"key":"10.7861\/clinmed.2021-0791_bib21","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1186\/s12879-018-3596-5","article-title":"Series of 10 dengue fever cases with unusual presentations and complications in Sri Lanka: a single centre experience in 2016","volume":"18","author":"Kularatne","year":"2018","journal-title":"BMC Infect Dis"},{"key":"10.7861\/clinmed.2021-0791_bib22","doi-asserted-by":"crossref","first-page":"4772","DOI":"10.1073\/pnas.1019295108","article-title":"Genetic elimination of dengue vector mosquitoes","volume":"108","author":"Wise de Valdez","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.7861\/clinmed.2021-0791_bib23","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/j.cell.2009.11.042","article-title":"A Wolbachia symbiont in Aedes aegypti limits infection with dengue, Chikungunya, and Plasmodium","volume":"139","author":"Moreira","year":"2009","journal-title":"Cell"},{"key":"10.7861\/clinmed.2021-0791_bib24","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4161\/hv.6.9.12739","article-title":"Development of Sanofi Pasteur tetravalent dengue vaccine","volume":"6","author":"Guy","year":"2010","journal-title":"Hum Vaccin"}],"container-title":["Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1470211824030069?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1470211824030069?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.7861\/clinmed.2021-0791","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T17:59:04Z","timestamp":1746813544000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1470211824030069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S1470211824030069"],"URL":"https:\/\/doi.org\/10.7861\/clinmed.2021-0791","relation":{},"ISSN":["1470-2118"],"issn-type":[{"value":"1470-2118","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dengue infection: Global importance, immunopathology and management","name":"articletitle","label":"Article Title"},{"value":"Clinical Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.7861\/clinmed.2021-0791","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 Royal College of Physicians 2022. All rights reserved.","name":"copyright","label":"Copyright"}]}}