{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T14:11:43Z","timestamp":1758636703223,"version":"3.40.4"},"reference-count":23,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T00:00:00Z","timestamp":1712361600000},"content-version":"vor","delay-in-days":583,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Medicine"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.7861\/clinmed.2022-0054","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T16:36:21Z","timestamp":1663950981000},"page":"403-408","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prevalence and clinical implication of thrombocytopenia and heparin-induced thrombocytopenia in patients who are critically ill with COVID-19"],"prefix":"10.1016","volume":"22","author":[{"given":"Reut Kassif","family":"Lerner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dor","family":"Lotan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Oren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Itelman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuval","family":"Neeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahar","family":"Dekel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eyal","family":"Heller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arsalan","family":"Abu-Much","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noya","family":"Shilo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rami","family":"Gilead","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evyatar","family":"Hubara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meir","family":"Mouallem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yael","family":"Haviv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Kogan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haim","family":"Mayan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itai M","family":"Pessach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.7861\/clinmed.2022-0054_bib1","unstructured":"World Health Organization, . WHO Coronavirus (COVID-19) Dashboard., WHO. https:\/\/covid19.who.int [Accessed 15 April 2022]."},{"key":"10.7861\/clinmed.2022-0054_bib2","article-title":"Heparin-induced thrombocytopenia is associated with a high risk of mortality in critical COVID-19 patients receiving heparin-involved treatment","author":"Liu","year":"2020","journal-title":"medRxiv"},{"key":"10.7861\/clinmed.2022-0054_bib3","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1002\/ajh.25829","article-title":"Hematological findings and complications of COVID-19","volume":"95","author":"Terpos","year":"2020","journal-title":"Am J Hematol"},{"key":"10.7861\/clinmed.2022-0054_bib4","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.cca.2020.03.022","article-title":"Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis","volume":"506","author":"Lippi","year":"2020","journal-title":"Clin Chim Acta"},{"key":"10.7861\/clinmed.2022-0054_bib5","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1007\/s00277-020-04019-0","article-title":"Mechanism of thrombocytopenia in COVID-19 patients","volume":"99","author":"Xu","year":"2020","journal-title":"Ann Hematol"},{"key":"10.7861\/clinmed.2022-0054_bib6","doi-asserted-by":"crossref","first-page":"E38","DOI":"10.1056\/NEJMc2007575","article-title":"Coagulopathy and antiphospholipid antibodies in patients with COVID-19","volume":"382","author":"Zhang","year":"2020","journal-title":"N Engl J Med"},{"key":"10.7861\/clinmed.2022-0054_bib7","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1111\/jth.14575","article-title":"Heparin-induced thrombocytopenia complicating extracorporeal membrane oxygenation support: Review of the literature and alternative anticoagulants","volume":"17","author":"Pollak","year":"2019","journal-title":"J Thromb Haemost"},{"key":"10.7861\/clinmed.2022-0054_bib8","article-title":"Heparin-induced thrombocytopenia in COVID-19","volume":"8","author":"Lingamaneni","year":"2020","journal-title":"J Investig Med High Impact Case Rep"},{"key":"10.7861\/clinmed.2022-0054_bib9","doi-asserted-by":"crossref","first-page":"E295","DOI":"10.1002\/ajh.25935","article-title":"Heparin induced thrombocytopenia antibodies in COVID-19","volume":"95","author":"Patell","year":"2020","journal-title":"Am J Hematol"},{"key":"10.7861\/clinmed.2022-0054_bib10","first-page":"328","article-title":"Detection of anti-heparin-PF4 complex antibodies in COVID-19 patients on heparin therapy","volume":"18","author":"Dragonetti","year":"2020","journal-title":"Blood Transfus"},{"key":"10.7861\/clinmed.2022-0054_bib11","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.1182\/bloodadvances.2018024489","article-title":"American Society of Hematology 2018 guidelines for management of venous thromboembolism: heparin-induced thrombocytopenia","volume":"22","author":"Cuker","year":"2018","journal-title":"Blood Adv"},{"key":"10.7861\/clinmed.2022-0054_bib12","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1309\/AJCPO64IWNLYCVVB","article-title":"Evaluation of the International Society on thrombosis and haemostasis and institutional diagnostic criteria of disseminated intravascular coagulation in pediatric patients","volume":"139","author":"Soundar","year":"2013","journal-title":"Am J Clin Pathol"},{"key":"10.7861\/clinmed.2022-0054_bib13","doi-asserted-by":"crossref","first-page":"458","DOI":"10.15585\/mmwr.mm6915e3","article-title":"Hospitalization rates and characteristics of patients hospitalized with laboratory-confirmed coronavirus disease 2019\u2014COVID-NET, 14 states, March 1\u201330, 2020","volume":"69","author":"Garg","year":"2020","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.7861\/clinmed.2022-0054_bib14","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1111\/jth.14848","article-title":"Thrombocytopenia and its association with mortality in patients with COVID-19","volume":"18","author":"Yang","year":"2020","journal-title":"J Thromb Haemost"},{"key":"10.7861\/clinmed.2022-0054_bib15","doi-asserted-by":"crossref","first-page":"e671","DOI":"10.1016\/S2352-3026(20)30217-9","article-title":"Haematological characteristics and risk factors in the classification and prognosis evaluation of COVID-19: a retrospective cohort study","volume":"7","author":"Liao","year":"2020","journal-title":"Lancet Haematol"},{"key":"10.7861\/clinmed.2022-0054_bib16","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1111\/jth.14832","article-title":"Exploring possible mechanisms for COVID-19 induced thrombocytopenia: Unanswered questions","volume":"18","author":"Amgalan","year":"2020","journal-title":"J Thromb Haemost"},{"key":"10.7861\/clinmed.2022-0054_bib17","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1055\/s-0037-1616068","article-title":"Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation","volume":"86","author":"Taylor","year":"2001","journal-title":"Thromb Haemost"},{"key":"10.7861\/clinmed.2022-0054_bib18","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/s13054-018-2073-2","article-title":"Thrombocytopenia in the ICU: disseminated intravascular coagulation and thrombotic microangiopathies\u2014what intensivists need to know","volume":"22","author":"Vincent","year":"2018","journal-title":"Critical Care"},{"key":"10.7861\/clinmed.2022-0054_bib19","doi-asserted-by":"crossref","first-page":"8S","DOI":"10.1177\/1076029618806424","article-title":"Disseminated intravascular coagulation: an update on pathogenesis, diagnosis, and therapeutic strategies","volume":"24","author":"Papageorgiou","year":"2018","journal-title":"Clin Appl Thromb Hemost"},{"key":"10.7861\/clinmed.2022-0054_bib20","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1111\/jth.14768","article-title":"Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia","volume":"18","author":"Tang","year":"2020","journal-title":"J Thromb Haemost"},{"key":"10.7861\/clinmed.2022-0054_bib21","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1378\/chest.06-2109","article-title":"The incidence of recognized heparin-induced thrombocytopenia in a large, tertiary care teaching hospital","volume":"131","author":"Smythe","year":"2007","journal-title":"Chest"},{"key":"10.7861\/clinmed.2022-0054_bib22","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1177\/1358863X19898253","article-title":"Heparin-induced thrombocytopenia (HIT): Review of incidence, diagnosis, and management","volume":"25","author":"Hogan","year":"2020","journal-title":"Vasc Med"},{"key":"10.7861\/clinmed.2022-0054_bib23","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1055\/s-0034-1398381","article-title":"Heparin-induced thrombocytopenia in critically ill patients","volume":"41","author":"Warkentin","year":"2015","journal-title":"Semin Thromb Hemost"}],"container-title":["Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S147021182402654X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S147021182402654X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.7861\/clinmed.2022-0054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T04:17:57Z","timestamp":1745295477000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S147021182402654X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["S147021182402654X"],"URL":"https:\/\/doi.org\/10.7861\/clinmed.2022-0054","relation":{},"ISSN":["1470-2118"],"issn-type":[{"type":"print","value":"1470-2118"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prevalence and clinical implication of thrombocytopenia and heparin-induced thrombocytopenia in patients who are critically ill with COVID-19","name":"articletitle","label":"Article Title"},{"value":"Clinical Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.7861\/clinmed.2022-0054","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 Royal College of Physicians 2022. All rights reserved.","name":"copyright","label":"Copyright"}]}}