{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:05:56Z","timestamp":1792674356799,"version":"4.5.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T00:00:00Z","timestamp":1712880000000},"content-version":"vor","delay-in-days":5064,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Medicine"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.7861\/clinmedicine.10-3-252","type":"journal-article","created":{"date-parts":[[2013,2,19]],"date-time":"2013-02-19T18:27:04Z","timestamp":1361298424000},"page":"252-258","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"title":["Motor neurone disease: a practical update on diagnosis and management"],"prefix":"10.1016","volume":"10","author":[{"given":"Pamela J","family":"Shaw","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Wood-Allum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.7861\/clinmedicine.10-3-252_bib1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/362059a0","article-title":"Mutations in Cu\/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis","volume":"362","author":"Rosen","year":"1993","journal-title":"Nature"},{"key":"10.7861\/clinmedicine.10-3-252_bib2","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1212\/01.wnl.0000296811.19811.db","article-title":"Genetics of familial amyotrophic lateral sclerosis","volume":"70","author":"Valdmanis","year":"2008","journal-title":"Neurology"},{"key":"10.7861\/clinmedicine.10-3-252_bib5","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1126\/science.1166066","article-title":"Mutations in the FUS\/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis","volume":"323","author":"Kwiatkowski","year":"2009","journal-title":"Science"},{"key":"10.7861\/clinmedicine.10-3-252_bib6","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/458415a","article-title":"Motor-neuron disease: Rogue gene in the family","volume":"458","author":"Sleegers","year":"2009","journal-title":"Nature"},{"key":"10.7861\/clinmedicine.10-3-252_bib7","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1212\/01.wnl.0000345041.83406.a2","article-title":"Natural history and clinical features of the flail arm and flail leg ALS variants","volume":"72","author":"Wijesekera","year":"2009","journal-title":"Neurology"},{"key":"10.7861\/clinmedicine.10-3-252_bib8","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1080\/146608200300079536","article-title":"El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis","volume":"1","author":"Brooks","year":"2000","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord"},{"key":"10.7861\/clinmedicine.10-3-252_bib9","series-title":"Guidance on the use of riluzole (Rilutek) for the treatment of motor neurone disease","year":"2001"},{"key":"10.7861\/clinmedicine.10-3-252_bib10","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1136\/jnnp.60.2.147","article-title":"Avoiding false positive diagnoses of motor neuron disease: lessons from the Scottish Motor Neuron Disease Register","volume":"60","author":"Davenport","year":"1996","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.7861\/clinmedicine.10-3-252_bib11","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1001\/archneur.57.1.109","article-title":"Amyotrophic lateral sclerosis mimic syndromes: a population-based study","volume":"57","author":"Traynor","year":"2000","journal-title":"Arch Neurol"},{"key":"10.7861\/clinmedicine.10-3-252_bib12","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/mus.20555","article-title":"Inappropriate surgeries resulting from misdiagnosis of early amyotrophic lateral sclerosis","volume":"34","author":"Srinivasan","year":"2006","journal-title":"Muscle Nerve"},{"key":"10.7861\/clinmedicine.10-3-252_bib13","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1212\/WNL.58.11.1593","article-title":"Mimic syndromes in sporadic cases of progressive spinal muscular atrophy","volume":"58","author":"Visser","year":"2002","journal-title":"Neurology"},{"key":"10.7861\/clinmedicine.10-3-252_bib14","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1080\/17482960802521126","article-title":"Awaji diagnostic algorithm increases sensitivity of El Escorial criteria for ALS diagnosis","volume":"10","author":"Carvalho","year":"2009","journal-title":"Amyotroph Lateral Scler"},{"key":"10.7861\/clinmedicine.10-3-252_bib15","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1136\/jnnp.74.9.1258","article-title":"Effect of a multidisciplinary amyotrophic lateral sclerosis (ALS) clinic on ALS survival: a population based study, 1996\u20132000","volume":"74","author":"Traynor","year":"2003","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.7861\/clinmedicine.10-3-252_bib16","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1056\/NEJM199403033300901","article-title":"A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS\/Riluzole Study Group","volume":"330","author":"Bensimon","year":"1994","journal-title":"N Engl J Med"},{"key":"10.7861\/clinmedicine.10-3-252_bib17","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/S0140-6736(96)91680-3","article-title":"Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis\/Riluzole Study Group II","volume":"347","author":"Lacomblez","year":"1996","journal-title":"Lancet"},{"key":"10.7861\/clinmedicine.10-3-252_bib18","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1212\/WNL.53.5.1059","article-title":"Nutritional status is a prognostic factor for survival in ALS patients","volume":"53","author":"Desport","year":"1999","journal-title":"Neurology"},{"key":"10.7861\/clinmedicine.10-3-252_bib19","first-page":"004030","article-title":"Enteral tube feeding for amyotrophic lateral sclerosis\/motor neuron disease","volume":"4","author":"Langmore","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"10.7861\/clinmedicine.10-3-252_bib20","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S1474-4422(05)70326-4","article-title":"Effects of non-invasive ventilation on survival and quality of life in patients with amyotrophic lateral sclerosis: a randomised controlled trial","volume":"5","author":"Bourke","year":"2006","journal-title":"Lancet Neurol"},{"key":"10.7861\/clinmedicine.10-3-252_bib3","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1126\/science.1154584","article-title":"TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis","volume":"319","author":"Sreedharan","year":"2008","journal-title":"Science"},{"key":"10.7861\/clinmedicine.10-3-252_bib4","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1126\/science.1165942","article-title":"Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6","volume":"323","author":"Vance","year":"2009","journal-title":"Science"}],"container-title":["Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1470211824044361?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1470211824044361?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.7861\/clinmedicine.10-3-252","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T06:41:06Z","timestamp":1761460866000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1470211824044361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["S1470211824044361"],"URL":"https:\/\/doi.org\/10.7861\/clinmedicine.10-3-252","relation":{},"ISSN":["1470-2118"],"issn-type":[{"value":"1470-2118","type":"print"}],"subject":[],"published":{"date-parts":[[2010,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Motor neurone disease: a practical update on diagnosis and management","name":"articletitle","label":"Article Title"},{"value":"Clinical Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.7861\/clinmedicine.10-3-252","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 Royal College of Physicians 2010. All rights reserved.","name":"copyright","label":"Copyright"}]}}