{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T16:45:06Z","timestamp":1772815506311,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2001,3,1]],"date-time":"2001-03-01T00:00:00Z","timestamp":983404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2001,3]]},"abstract":"<jats:p>Increased neonatal nucleated red blood cell counts are thought to be related to intrauterine hypoxemia. We sought to determine the effect of increasing circulatory impairment in fetuses on the neonatal nucleated red blood cell count. One hundred thirty\u2010four singleton pregnancies were included in the study and were allocated to 4 study groups according to Doppler findings. The systolic\u2010to\u2010diastolic ratios of the umbilical artery, fetal aorta, middle cerebral artery, and uterine arteries were recorded. Fetuses were assigned to the following groups on the basis of the last Doppler examination before delivery: group 1, normal systolic\u2010to\u2010diastolic ratios in the examined vessels; group 2, a systolic\u2010to\u2010diastolic ratio greater than 2 SD above the mean for gestational age in the umbilical artery or fetal aorta and no abnormal Doppler findings in the uterine arteries; group 3, systolic\u2010to\u2010diastolic ratios greater than 2 SD above the mean for gestational age in all examined vessels; and group 4, absence of end\u2010diastolic velocity in the umbilical artery or fetal aorta and systolic\u2010to\u2010diastolic ratios greater than 2 SD above the mean for gestational age in the uterine arteries. A blood sample from the umbilical artery was obtained within 1 minute after birth, and nucleated red blood cells per 100 white blood cells were counted by light microscopy. Nucleated red blood cell counts were higher in fetuses in group 4 (median, 72.0; range, 9\u2010720; P &lt; .001) and group 3 (median, 38.4; range, 7\u2010201; P &lt; .001) than in fetuses in group 1 (median, 5.1; range, 0\u201020). Neonates in group 4 had significantly lower birth weights (P &lt; .001), lower arterial and venous pH values (P &lt; .05), and lower Apgar scores after 5 minutes (P &lt; .01) as well as an increased likelihood of cesarean delivery because of fetal distress (P &lt; .001). The number of fetuses in group 4 with a cord blood base deficit of less than \u20108 mmol\/L was increased. Nucleated red blood cell counts were comparable in fetuses in group 2 (median, 5.4; range, 0\u201037) and group 1. In groups 1 to 3 no brain\u2010sparing effect occurred, whereas in 15 of 21 cases in group 4 a brain\u2010sparing effect was present. Multivariate analysis revealed that Doppler results of the umbilical artery, fetal aorta, and uterine arteries were independent determinants of neonatal nucleated red blood cell count. Increasing abnormalities seen on fetoplacental Doppler studies are associated with increasing numbers of nucleated red blood cells at birth. Given the known relationship between abnormal Doppler flow and intrauterine hypoxemia, the neonatal nucleated red blood cell count might become an additional valuable tool in the surveillance of growth\u2010restricted fetuses.<\/jats:p>","DOI":"10.7863\/jum.2001.20.3.183","type":"journal-article","created":{"date-parts":[[2017,1,9]],"date-time":"2017-01-09T19:51:05Z","timestamp":1483991465000},"page":"183-190","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Neonatal nucleated red blood cell counts: relationship to abnormal fetoplacental circulation detected by Doppler studies."],"prefix":"10.7863","volume":"20","author":[{"given":"R","family":"Axt-Fliedner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Ertan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H J","family":"Hendrik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,3]]},"container-title":["Journal of Ultrasound in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.7863%2Fjum.2001.20.3.183","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.7863\/jum.2001.20.3.183","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T15:55:23Z","timestamp":1700409323000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.7863\/jum.2001.20.3.183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001,3]]}},"alternative-id":["10.7863\/jum.2001.20.3.183"],"URL":"https:\/\/doi.org\/10.7863\/jum.2001.20.3.183","archive":["Portico"],"relation":{},"ISSN":["0278-4297","1550-9613"],"issn-type":[{"value":"0278-4297","type":"print"},{"value":"1550-9613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,3]]},"assertion":[{"value":"2001-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}