{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T05:28:31Z","timestamp":1785562111947,"version":"3.56.0"},"reference-count":13,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2002,8,1]],"date-time":"2002-08-01T00:00:00Z","timestamp":1028160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2002,8]]},"abstract":"<jats:p><jats:bold><jats:italic>Objective<\/jats:italic><\/jats:bold>. To characterize normal growth of the fetal fourth ventricle on ultrasonography throughout pregnancy. <jats:bold><jats:italic>Methods<\/jats:italic><\/jats:bold>. Consecutive biometric measurements and fetal organ scans were obtained from 299 patients undergoing fetal anatomic surveys between 13 and 40 weeks' gestation. Using 7\u2010 and 3.5\u2010MHz transducers for early (13\u2010 to 17\u2010week) and late (&gt;17\u2010week) examinations, respectively, we scanned the fetal head in the axial plane with special focus on the posterior fossa of the brain. The fourth ventricle was identified, and its anteroposterior diameter and width were measured. A \u201ctriangle\u201d formula was used for calculating its circumference and area. <jats:bold><jats:italic>Results<\/jats:italic><\/jats:bold>. The fourth ventricle was shown as a hypoechoic triangle below the level of the cerebellum. A linear regression line of the fourth ventricle was observed across gestational age, and a first\u2010degree correlation was found between gestational age and anteroposterior diameter of the fourth ventricle (<jats:italic>r<\/jats:italic> = 0.894; <jats:italic>P<\/jats:italic> &lt; .0001; <jats:italic>y<\/jats:italic> = \u20130.84 + 0.23 \u00d7 gestational age), its width (<jats:italic>r<\/jats:italic> = 0.657; <jats:italic>P<\/jats:italic> &lt; .0001; <jats:italic>y<\/jats:italic> = 3.82 + 0.14 \u00d7 gestational age), its circumference (<jats:italic>r<\/jats:italic> = 0.843; <jats:italic>P<\/jats:italic> &lt; .0001; <jats:italic>y<\/jats:italic> = 5.11 + 0.58 \u00d7 gestational age), and its area (<jats:italic>r<\/jats:italic> = 0.844; <jats:italic>P<\/jats:italic> &lt; .0001; <jats:italic>y<\/jats:italic> = \u201310.11 + 1.17 \u00d7 gestational age). Twelve enlarged fourth ventricles were found between 14 and 16 weeks, but results of follow\u2010up scans at 20 weeks were normal. <jats:bold><jats:italic>Conclusions<\/jats:italic><\/jats:bold>. An isolated enlarged fourth ventricle in the early second trimester might represent a normal variant; it should be followed, but decisions about the fate of the pregnancy should not be based solely on this finding.<\/jats:p>","DOI":"10.7863\/jum.2002.21.8.849","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T21:19:36Z","timestamp":1484083176000},"page":"849-856","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Ultrasonographic Nomograms of the Fetal Fourth Ventricle"],"prefix":"10.7863","volume":"21","author":[{"given":"Israel","family":"Goldstein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imad R.","family":"Makhoul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ada","family":"Tamir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bat-Sheva","family":"Rajamim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Nisman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,8]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Moore KL Persaud TVN. Sistema nervioso. In: Moore KL Persaud TVN (eds). Embriologia Clinica. Madrid Spain: Interamericana\u2013McGraw-Hill; 1993:413\u2013453."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.192.2.8029392"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(16)32283-9"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(85)90298-4"},{"key":"e_1_2_6_6_1","unstructured":"Reece EA Goldstein I Hobbins JC. First-trimester ultrasound. In: Reece EA Goldstein I Hobbins JC (eds). Fundamentals of Obstetric & Gynecologic Ultrasound. Norwalk CT: Appleton & Lange; 1994: 15\u201326."},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1995.05030151.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.192.1.8208946"},{"key":"e_1_2_6_9_1","first-page":"428","volume":"94","year":"1997","journal-title":"Radiol Med (Torino)"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.166.2.8553961"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.193.3.7972820"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199710)17:10<907::AID-PD172>3.0.CO;2-Q"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(1998100)18:10<997::AID-PD392>3.0.CO;2-O"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/jmf.10.1.23.27"}],"container-title":["Journal of Ultrasound in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.7863%2Fjum.2002.21.8.849","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.7863\/jum.2002.21.8.849","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T15:01:15Z","timestamp":1700319675000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.7863\/jum.2002.21.8.849"}},"subtitle":["Additional Tool for Detecting Abnormalities of the Posterior Fossa"],"short-title":[],"issued":{"date-parts":[[2002,8]]},"references-count":13,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2002,8]]}},"alternative-id":["10.7863\/jum.2002.21.8.849"],"URL":"https:\/\/doi.org\/10.7863\/jum.2002.21.8.849","archive":["Portico"],"relation":{},"ISSN":["0278-4297","1550-9613"],"issn-type":[{"value":"0278-4297","type":"print"},{"value":"1550-9613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,8]]},"assertion":[{"value":"2001-12-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-05-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-08-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}