{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:46:05Z","timestamp":1790711165127,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,6,1]],"date-time":"2004-06-01T00:00:00Z","timestamp":1086048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:p><jats:bold><jats:italic>Objective.<\/jats:italic><\/jats:bold> To study the value of choroid plexus dysmorphology as a screening tool for the first\u2010trimester sonographic diagnosis of holoprosencephaly in a high\u2010risk population. <jats:bold><jats:italic>Methods.<\/jats:italic><\/jats:bold> A total of 378 consecutive pregnancies undergoing chorionic villus sampling between 11 and 14 weeks' gestation were scanned before the procedure, following the recommendations of the Fetal Medicine Foundation (London, England). A cross\u2010sectional view of the fetal brain, including the visualization of both choroid plexuses (the \u201cbutterfly\u201d sign), was obtained in all cases. <jats:bold><jats:italic>Results.<\/jats:italic><\/jats:bold> There were 3 cases in which the butterfly sign was not identified. In these cases, the first\u2010trimester diagnosis of holoprosencephaly was confirmed by the presence of a single monoventricular cavity and fused thalami. Two of these fetuses had features of facial dysmorphism at the time of presentation and 2 had extracranial anomalies, including a cystic hygroma in 1 and a small omphalocele and polydactyly in another. Chromosomal analysis showed trisomy 13 in 2 cases and a ring chromosome 13 in the other. <jats:bold><jats:italic>Conclusions.<\/jats:italic><\/jats:bold> This series suggests that failure to identify the butterfly sign is a warning sign of holoprosencephaly in the first trimester. Systematic identification of the butterfly sign at the time of sonographic assessment of nuchal translucency provides a valuable tool for the early screening of holoprosencephaly.<\/jats:p>","DOI":"10.7863\/jum.2004.23.6.761","type":"journal-article","created":{"date-parts":[[2017,1,9]],"date-time":"2017-01-09T18:57:12Z","timestamp":1483988232000},"page":"761-765","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["First\u2010Trimester Sonographic Diagnosis of Holoprosencephaly"],"prefix":"10.7863","volume":"23","author":[{"given":"Waldo","family":"Sepulveda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Dezerega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Be","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199805)18:5<477::AID-PD387>3.0.CO;2-J"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0960-7692.2001.00154.x"},{"key":"e_1_2_8_4_1","unstructured":"McGahan JP Pilu G Nyberg DA. Cerebral malformations. In: Nyberg DA McGahan JP Pretorius DH Pilu G (eds). Diagnostic Imaging of Fetal Anomalies. Philadelphia PA: Lippincott Williams & Wilkins;2003:221\u2013290."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)11280-6"},{"key":"e_1_2_8_6_1","unstructured":"Nicolaides KH Sebire NJ Snijders RJM (eds). The 11\u201314 Week Scan. The Diagnosis of Fetal Abnormalities. Carnforth England: Parthenon Publishing;1999."},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1997.10060429.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1992.11.1.57"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1995.14.8.631"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1999.13050356.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(99)00059-4"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000263552"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19990917)86:3<205::AID-AJMG2>3.0.CO;2-N"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(01)00571-9"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.194.1.7997556"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1998.11040258.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199708)17:8<753::AID-PD148>3.0.CO;2-P"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1997.10060375.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1998.tb09350.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.200"}],"container-title":["Journal of Ultrasound in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.7863%2Fjum.2004.23.6.761","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.7863\/jum.2004.23.6.761","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T15:31:40Z","timestamp":1700235100000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.7863\/jum.2004.23.6.761"}},"subtitle":["Value of the \u201cButterfly\u201d Sign"],"short-title":[],"issued":{"date-parts":[[2004,6]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2004,6]]}},"alternative-id":["10.7863\/jum.2004.23.6.761"],"URL":"https:\/\/doi.org\/10.7863\/jum.2004.23.6.761","archive":["Portico"],"relation":{},"ISSN":["0278-4297","1550-9613"],"issn-type":[{"value":"0278-4297","type":"print"},{"value":"1550-9613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,6]]},"assertion":[{"value":"2004-01-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2004-02-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2004-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}