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Forty\u2010three patients with 51 symptomatic uterine fibroids were treated with MRI\u2010guided high\u2010intensity focused US with shot sonication, which was a small acoustic focus of higher intensity with a shorter time (2 seconds) of US exposure and a shorter cooling time (2\u20133 seconds). The treatment efficacy and adverse events were analyzed, and the changes in the severity of symptoms and the reduction in fibroid volume were assessed 3 and 6 months after the procedure. All patients were successfully treated in a single session, without major complications, and the mean nonperfused volume ratio \u00b1 SD was 84.3% \u00b1 15.7% (range, 33.8%\u2013100%).Complete ablation was achieved in 13 T2\u2010hypointense fibroids from 10 patients, and partial ablation was achieved in 38 fibroids from 33 patients. The overall mean treatment time was 135.0 \u00b1 50.9 minutes (2.2 \u00b1 0.8 hours). The transformed symptom severity scores and mean fibroid volumes decreased significantly after treatment (<jats:italic>P<\/jats:italic> &lt; .05). In conclusion, MRI\u2010guided high\u2010intensity focused US with shot sonication is a feasible, safe, and effective technique for ablation of uterine fibroids and complete ablation of T2\u2010hypointense fibroids.<\/jats:p>","DOI":"10.7863\/ultra.14.12080","type":"journal-article","created":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T21:57:14Z","timestamp":1448488634000},"page":"2293-2303","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Feasibility, Safety, and Efficacy of Accurate Uterine Fibroid Ablation Using Magnetic Resonance Imaging\u2013Guided High\u2010Intensity Focused Ultrasound With Shot 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