{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:26:01Z","timestamp":1789381561455,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,4,18]],"date-time":"2016-04-18T00:00:00Z","timestamp":1460937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate fetal lung growth using 3\u2010dimensional sonography in healthy fetuses and those with congenital diaphragmatic hernia (CDH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Right and total lung volumes were serially evaluated by 3\u2010dimensional sonography in 66 healthy fetuses and 52 fetuses with left\u2010sided CDH between 20 and 37 weeks' menstrual age. Functions fitted to these parameters were compared for 2 groups: (1) healthy versus those with CDH; and (2) fetuses with CHD who survived versus those who died.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fetal right and total lung volumes as well as fetal observed\u2010to\u2010expected right and total lung volume ratios were significantly lower in fetuses with CDH than healthy fetuses (<jats:italic>P<\/jats:italic>&lt; .001) and in those fetuses with CDH who died (<jats:italic>P<\/jats:italic>&lt; .001). The observed\u2010to\u2010expected right and total lung volume ratios did not vary with menstrual age in healthy fetuses or in those with CDH (independent of outcome).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lung volume rates were lower in fetuses with left\u2010sided CDH compared to healthy fetuses, as well as in fetuses with CDH who died compared to those who survived. The observed\u2010to\u2010expected right and total lung volume ratios were relatively constant throughout menstrual age in fetuses with left\u2010sided CDH, suggesting that the origin of their lung growth abnormalities occurred before 20 weeks and did not progress. The observed\u2010to\u2010expected ratios may be useful in predicting the outcome in fetuses with CDH independent of menstrual age.<\/jats:p><\/jats:sec>","DOI":"10.7863\/ultra.15.08005","type":"journal-article","created":{"date-parts":[[2016,4,21]],"date-time":"2016-04-21T22:07:52Z","timestamp":1461276472000},"page":"1159-1166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Growth Patterns of Fetal Lung Volumes in Healthy Fetuses and Fetuses With Isolated Left\u2010Sided Congenital Diaphragmatic Hernia"],"prefix":"10.1002","volume":"35","author":[{"given":"Rodrigo","family":"Ruano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid Schwach 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