{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T10:49:45Z","timestamp":1771670985312,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,1,21]],"date-time":"2017-01-21T00:00:00Z","timestamp":1484956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study was performed to determine the frequency, predictors, and outcomes of ultrasound (US) correlates for non\u2010mass enhancement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From January 2005 to December 2011, a retrospective review of 5837 consecutive breast magnetic resonance imaging examinations at our institution identified 918 non\u2010mass enhancing lesions for which follow\u2010up or biopsy was recommended. Retrospective review of the images identified 879 of 918 lesions (96%) meeting criteria for non\u2010mass enhancement. Patient demographics, pathologic results, and the presence of an adjacent landmark were recorded. Targeted US examinations were recommended for 331 of 879 cases (38%), and 284 of 331 women (86%) underwent US evaluations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The US correlate rate for non\u2010mass enhancement was 23% (64 of 284). An adjacent landmark was significantly associated with a US correlate (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Biopsy was recommended for 43 of 64 correlates (67%). Ultrasound\u2010guided biopsy was performed on 39 of 43 (91%); 7 of 39 (18%) were malignant. No correlate was seen for 220 of 284 lesions (77%). At magnetic resonance imaging\u2013guided biopsy, 14 of 117 (12%) were malignancies. For all biopsied non\u2010mass enhancements, the malignancy rate was 18% (55 of 308) and was significantly more prevalent in the setting of a known index cancer (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), older age (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), the presence of a landmark (<jats:italic>P<\/jats:italic>\u2009=\u2009.002), and larger lesion size (<jats:italic>P<\/jats:italic>\u2009=\u2009.019).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Non\u2010mass enhancement with an adjacent landmark is more likely to have a US correlate compared to non\u2010mass enhancement without an adjacent landmark. Non\u2010mass enhancement in the setting of a known index cancer, older age, a landmark, and larger lesion size is more likely to be malignant. However, no statistical difference was detected in the rate of malignancy between non\u2010mass enhancement with (18%) or without (12%) a correlate. Absence of a correlate does not obviate the need to biopsy suspicious non\u2010mass enhancement.<\/jats:p><\/jats:sec>","DOI":"10.7863\/ultra.16.03001","type":"journal-article","created":{"date-parts":[[2017,1,21]],"date-time":"2017-01-21T09:07:28Z","timestamp":1484989648000},"page":"493-504","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Magnetic Resonance Imaging\u2013Directed Ultrasound Imaging of Non\u2010Mass Enhancement in the Breast: Outcomes and Frequency of Malignancy"],"prefix":"10.7863","volume":"36","author":[{"given":"Adrienne R.","family":"Newburg","sequence":"first","affiliation":[{"name":"Department of Radiology University of Massachusetts Medical School Worcester Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chloe M.","family":"Chhor","sequence":"additional","affiliation":[{"name":"Department of Radiology New York University School of Medicine New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leng Leng","family":"Young Lin","sequence":"additional","affiliation":[{"name":"Department of Radiology New York University School of Medicine New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha L.","family":"Heller","sequence":"additional","affiliation":[{"name":"Department of Radiology New York University School of Medicine New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Gillman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Lenox Hill Hospital New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hildegard K.","family":"Toth","sequence":"additional","affiliation":[{"name":"Department of Radiology New York University School of Medicine New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Moy","sequence":"additional","affiliation":[{"name":"Department of Radiology New York University School of Medicine New York New York USA"},{"name":"Department of Center for Advanced Imaging Innovation and Research New York University School of Medicine New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.09.2707"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2005.06.019"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.20784"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-010-0561-9"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.3987"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.14366\/usg.14046"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/2156-7514.82338"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ro.2011.08.002"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2012.31.7.1033"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14140474"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2013.11958"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-015-3807-z"},{"key":"e_1_2_6_14_1","unstructured":"American College of Radiology. 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