{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T19:39:21Z","timestamp":1765827561115},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T00:00:00Z","timestamp":1492041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The purpose of this study was to investigate the diagnostic performance of acoustic radiation force impulse (ARFI) in assessing liver fibrosis preoperatively in infants with biliary atresia (BA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 50 consecutive infants with BA and 50 healthy infants who underwent ARFI examination were recruited. Siemens Acuson S2000 in Virtual Touch Quantification mode (Siemens Medical Solutions, Mountain View, CA) was used to measure shear wave speeds (SWSs). All infants with BA underwent a liver biopsy within 3 days after ARFI imaging. The liver fibrosis stages of specimens were defined according to the Batts\u2010Ludwig scoring system. The correlation analysis was performed between SWSs and pathological findings. Cut\u2010off values were determined using receiver operating characteristic (ROC) curves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean SWS in the BA group was significantly higher than controls (mean\u2009\u00b1\u2009standard deviation): 1.89\u2009\u00b1\u20090.45 versus 1.12\u2009\u00b1\u20090.06\u2009m\/s; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). A significant correlation was found between the SWSs and fibrosis stages (<jats:italic>r<\/jats:italic>\u2009=\u20090.719, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). The cut\u2010off value for predicting significant fibrosis (F\u2009\u2265\u20092), severe fibrosis (F\u2009\u2265\u20093), and cirrhosis (F\u2009=\u20094) was 1.53, 1.80 and 2.16\u2009m\/s, respectively, and the area under the ROC curve was 0.823, 0.884 and 0.917, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Acoustic radiation force impulse imaging showed significant correlation with the severity of liver fibrosis by comparing it with liver fibrosis biopsy pathology. It may be an effective method for liver fibrosis assessment, prognosis prediction, and clinical management in infants with BA.<\/jats:p><\/jats:sec>","DOI":"10.7863\/ultra.16.08043","type":"journal-article","created":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T16:11:38Z","timestamp":1492099898000},"page":"1571-1578","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Acoustic Radiation Force Impulse Imaging for Assessing Liver Fibrosis Preoperatively in Infants With Biliary Atresia: Comparison With Liver Fibrosis Biopsy Pathology"],"prefix":"10.7863","volume":"36","author":[{"given":"Fen","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Ultrasound Xinhua Hospital, Affiliated to Shanghai Jiaotong University School of Medicine Shanghai 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