{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T18:04:26Z","timestamp":1783965866026,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>We measured the carotid intima\u2010media thickness, a surrogate marker of early atherosclerosis, in patients with carpal tunnel syndrome compared to a control group to evaluate the risk of atherosclerotic disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between January 2011 and December 2011, female patients presenting to the outpatient neurology clinic for pain and paresthesia in the hands were screened for study enrollment. Patients 30 years or older were eligible for the study if they did not have a history of stroke or cardiovascular disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the study period, 111 patients (58 in the carpal tunnel syndrome group and 53 in the control group) were enrolled, with a mean age of 56 years (range, 32\u201379 years). There were no significant differences in baseline characteristics except maximum carotid intima\u2010media thickness and body mass index. The maximum intima\u2010media thickness was greater in the carpal tunnel syndrome group (mean \u00b1 SD, 1.05 \u00b1 0.17 mm) than the control group (0.85 \u00b1 0.22 mm; <jats:italic>P<\/jats:italic> &lt; .0001). The body mass index was greater among the controls (<jats:italic>P<\/jats:italic> = .012). Simple linear regression analysis revealed that age (<jats:italic>P<\/jats:italic> &lt; .0001), carpal tunnel syndrome (<jats:italic>P<\/jats:italic> &lt; .0001), hypertension (<jats:italic>P<\/jats:italic> = .022), and systolic blood pressure (<jats:italic>P<\/jats:italic> = .034) were statistically significantly associated with increased intima\u2010media thickness. Multiple linear regression analysis revealed that hypertension (<jats:italic>P<\/jats:italic> = .033), systolic blood pressure (<jats:italic>P<\/jats:italic> = .022), age (<jats:italic>P<\/jats:italic> &lt; .0001), and carpal tunnel syndrome (<jats:italic>P<\/jats:italic> &lt; .0001) were significantly associated with increased intima\u2010media thickness, with carpal tunnel syndrome being the most influential factor (\u03b2= 0.489).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The maximum carotid intima\u2010media thickness was significantly increased in patients with carpal tunnel syndrome compared to controls. Chronic inflammation beyond the traditional cardiovascular risk factors might be related to increased carotid intima\u2010media thickness in patients with carpal tunnel syndrome.<\/jats:p><\/jats:sec>","DOI":"10.7863\/ultra.32.10.1753","type":"journal-article","created":{"date-parts":[[2013,9,24]],"date-time":"2013-09-24T19:44:35Z","timestamp":1380051875000},"page":"1753-1757","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Carotid Intima\u2010Media Thickness in Patients With Carpal Tunnel Syndrome"],"prefix":"10.1002","volume":"32","author":[{"given":"Joong Hyun","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi Nae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung 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