{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T12:27:34Z","timestamp":1759580854173},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Doctoral Foundation of the Chinese Ministry of Education","award":["20090001110092"],"award-info":[{"award-number":["20090001110092"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The clinical utility of contrast\u2010enhanced sonography in portal hypertension remains unclear. We explored the feasibility of using contrast\u2010enhanced sonography for noninvasive assessment of portal venous pressure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty healthy individuals (control group; 9 men; mean age, 46.4 years) and 18 patients with portal hypertension (15 men; mean age, 46.2 years) were enrolled in this study. The portal hypertension group included patients who underwent splenectomy and pericardial blood vessel disarticulation at our hospital from October 2010 to March 2011. One week before surgery, patients with portal hypertension underwent preoperative liver contrast\u2010enhanced sonography. Two\u2010dimensional, Doppler, and contrast\u2010enhanced sonographic parameters were compared between the groups. Portal venous pressure was measured intraoperatively by portal vein puncture in the portal hypertension group, and its relationship with the other parameters was analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 2\u2010dimensional, Doppler, and contrast\u2010enhanced sonographic parameters differed between the groups (<jats:italic>P<\/jats:italic> &lt; .01). Portal venous pressure was inversely correlated with the area under the portal vein\/hepatic artery time\u2010intensity curve ratio (Qp\/Qa), portal vein\/hepatic artery strength ratio (Ip\/Ia), and portal vein\/hepatic artery wash\u2010in perfusion slope ratio (\u03b2p\/\u03b2a), with correlation coefficients of \u22120.701, \u22120.625, and \u22120.494, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Measurement of the liver contrast\u2010enhanced sonographic parameters Qp\/Qa, Ip\/Ia, and \u03b2p\/\u03b2a could be used as a new quantitative method for noninvasively assessing portal venous pressure.<\/jats:p><\/jats:sec>","DOI":"10.7863\/ultra.33.11.1971","type":"journal-article","created":{"date-parts":[[2014,10,21]],"date-time":"2014-10-21T21:46:01Z","timestamp":1413927961000},"page":"1971-1977","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Contrast\u2010Enhanced 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