{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T23:40:02Z","timestamp":1746315602270,"version":"3.40.4"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Owing to the fact that the potential frequency of endothelial dysfunction and early atherosclerosis might be higher in Beh\u00e7et disease, characterized by acute and chronic inflammatory attacks, it may lead to impairment in flow\u2010mediated dilatation and an increase in epicardial adipose tissue thickness. Therefore, we aimed to evaluate whether epicardial adipose tissue thickness and brachial artery flow\u2010mediated dilatation as markers of early atherosclerosis and endothelial dysfunction were associated with Beh\u00e7et disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010five patients with Beh\u00e7et disease and 35 healthy volunteers were included in this study. Epicardial adipose tissue was identified as an anechoic space between epicardial layers on 2\u2010dimensional images, and its thickness was measured on the free wall of the right ventricle. Right brachial artery flow\u2010mediated dilatation was assessed according to recent guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum \u03b3\u2010glutamyl transferase (GGT) levels and epicardial adipose tissue thickness were significantly higher (<jats:italic>P<\/jats:italic>= .001;<jats:italic>P<\/jats:italic>&lt; .001 respectively), whereas flow\u2010mediated, endothelium\u2010dependent dilatation was significantly lower in the Beh\u00e7et disease group than controls (<jats:italic>P<\/jats:italic>&lt; .001). There was a significant negative association between epicardial adipose tissue thickness and flow\u2010mediated dilatation (<jats:italic>P<\/jats:italic>&lt; .001). Epicardial adipose tissue thickness was also positively correlated with Beh\u00e7et disease activity (<jats:italic>P<\/jats:italic>&lt; .001), Beh\u00e7et disease duration (<jats:italic>P<\/jats:italic>&lt; .001), and waist circumference (<jats:italic>P<\/jats:italic>&lt; .001). Flow\u2010mediated dilatation was negatively correlated with GGT (<jats:italic>P<\/jats:italic>&lt; .001), Beh\u00e7et disease activity (<jats:italic>P<\/jats:italic>&lt; .001), and age (<jats:italic>P<\/jats:italic>&lt; .001). There was also a significant association between GGT and Beh\u00e7et disease activity (<jats:italic>P<\/jats:italic>&lt; .001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We found that epicardial adipose tissue thickness was significantly higher and flow\u2010mediated dilatation was significantly lower in patients with Beh\u00e7et disease than in controls. We suggest that identification of increased epicardial adipose tissue might aid in the diagnosis and treatment of possible coronary artery disease in patients with Beh\u00e7et disease.<\/jats:p><\/jats:sec>","DOI":"10.7863\/ultra.33.8.1393","type":"journal-article","created":{"date-parts":[[2014,7,25]],"date-time":"2014-07-25T17:49:44Z","timestamp":1406310584000},"page":"1393-1400","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Increased Epicardial Adipose Tissue Thickness on Transthoracic Echocardiography in Patients With Beh\u00e7et 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