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However, the practical applications of this imaging technique were not included. This article reviews and discusses the published literature on the clinical use of dynamic contrast\u2010enhanced US. This review finds that dynamic contrast\u2010enhanced US imaging is the most sensitive cross\u2010sectional real\u2010time method for measuring the perfusion of parenchymatous organs noninvasively. It can measure parenchymal perfusion and therefore can differentiate between benign and malignant tumors. The most important routine clinical role of dynamic contrast\u2010enhanced US is the prediction of tumor responses to chemotherapy within a very short time, shorter than using Response Evaluation Criteria in Solid Tumors criteria. Other applications found include quantifying the hepatic transit time, diabetic kidneys, transplant grafts, and Crohn disease. In addition, the problems involved in using dynamic contrast\u2010enhanced US are discussed.<\/jats:p>","DOI":"10.7863\/ultra.34.2.179","type":"journal-article","created":{"date-parts":[[2015,1,22]],"date-time":"2015-01-22T22:44:34Z","timestamp":1421966674000},"page":"179-196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Dynamic Contrast\u2010Enhanced Ultrasound for Quantification of Tissue Perfusion"],"prefix":"10.1002","volume":"34","author":[{"given":"Eckhart","family":"Fr\u00f6hlich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhold","family":"Muller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Wu","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"Schreiber-Dietrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph F.","family":"Dietrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-1432"},{"issue":"8","key":"e_1_2_7_3_1","first-page":"11","article-title":"Technology overview: SonoVue (Bracco, Milan)","volume":"14","author":"Greis C","year":"2004","journal-title":"Eur Radiol"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi214"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.05.1192"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.04.023"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-2046"},{"key":"e_1_2_7_8_1","author":"Lamuraglia M","journal-title":"Dynamic contrast-enhanced Doppler ultrasound (DCE-US) is a useful radiological assessment to early predict the outcome of patients with gastrointestinal stromal tumors (GIST) treated with imatinib (IM)"},{"key":"e_1_2_7_9_1","first-page":"377","article-title":"Recommandations pour la prise en charge des tumeurs stromales gastro-intestinales","volume":"12","author":"Le Cesne A","year":"2005","journal-title":"Hepato Gastro"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.3.205"},{"key":"e_1_2_7_11_1","author":"Lassau N","journal-title":"French multicentric prospective evaluation of dynamic contrast-enhanced ultrasound (DCE-US) for the evaluation of antiangiogenic treatments in 400 patients"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-963785"},{"issue":"1","key":"e_1_2_7_13_1","first-page":"S57","article-title":"Contrast-enhanced ultrasound (CEUS) in the diagnostic algorithm of hepatocellular and cholangiocellular carcinoma: comments on the AASLD guidelines","volume":"33","author":"Dietrich CF","year":"2012","journal-title":"Ultraschall Med"},{"issue":"1","key":"e_1_2_7_14_1","first-page":"S3","article-title":"Liver tumor characterization: review of the literature","volume":"33","author":"Dietrich CF","year":"2012","journal-title":"Ultraschall Med"},{"issue":"1","key":"e_1_2_7_15_1","first-page":"S22","article-title":"Liver tumor characterization: comments and illustrations regarding guidelines","volume":"33","author":"Dietrich CF","year":"2012","journal-title":"Ultraschall Med"},{"key":"e_1_2_7_16_1","author":"Lassau N","journal-title":"Functional imaging using DCE-US: which parameters for the early evaluation of antiangiogenic therapies?"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1245450"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1281676"},{"issue":"1","key":"e_1_2_7_19_1","first-page":"S39","article-title":"EFSUMB guidelines 2011: comment on emergent indications and visions","volume":"33","author":"Dietrich CF","year":"2012","journal-title":"Ultraschall Med"},{"issue":"1","key":"e_1_2_7_20_1","first-page":"S11","article-title":"EFSUMB guidelines 2011: comments and illustrations","volume":"33","author":"Dietrich CF","year":"2012","journal-title":"Ultraschall Med"},{"key":"e_1_2_7_21_1","first-page":"11","article-title":", Dietrich CF, Choi BI, et al. 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