{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:33:10Z","timestamp":1777710790807,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the accuracy and change over time of contrast\u2010enhanced ultrasound (US) imaging for assessing residual blood flow after transarterial chemoembolization of hepatocellular carcinoma with drug\u2010eluting beads at 2 different follow\u2010up intervals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from 16 tumors treated by transarterial chemoembolization with drug\u2010eluting beads were successfully obtained. As part of the study, patients provided consent to undergo contrast\u2010enhanced US examinations the morning before embolization, 1 to 2 weeks after embolization, and the morning before follow\u2010up contrast\u2010enhanced magnetic resonance imaging (MRI) or computed tomography (CT) (1 month after embolization). Blinded review of contrast\u2010enhanced US and MRI\/CT studies were performed by 2 radiologists who evaluated residual flow as no change, partial change, or no residual flow. Inter\u2010 and intra\u2010reader variability rates were calculated before discordant individual reads were settled by consensus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The only adverse event reported during the contrast\u2010enhanced US examinations was a single episode of transient back pain. Contrast\u2010enhanced US at 1 to 2 weeks after embolization (n = 14) resulted in 100% sensitivity, specificity, positive predictive value, negative predictive value, and accuracy. Contrast\u2010enhanced US 1 month after embolization (n = 15) resulted in 75% sensitivity, 100% specificity, 100% positive predictive value, 92% negative predictive value, and 93% accuracy. Inter\u2010reader agreement was 86% for contrast\u2010enhanced US at 1 to 2 weeks, 93% for contrast\u2010enhanced US at 1 month, and 100% for contrast\u2010enhanced MRI\/CT at 1 month, whereas intra\u2010reader agreement was 71% for contrast\u2010enhanced US at 1 to 2 weeks, 87% for contrast\u2010enhanced US at 1 month, and 91% for MRI\/CT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Contrast\u2010enhanced US imaging at 1 to 2 weeks after the procedure may be a viable alternative to MRI\/CT for evaluating residual blood flow after transarterial chemoembolization with drug\u2010eluting beads, albeit with a higher degree of reader variability.<\/jats:p><\/jats:sec>","DOI":"10.7863\/ultra.34.5.859","type":"journal-article","created":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T19:40:46Z","timestamp":1429904446000},"page":"859-867","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Contrast\u2010Enhanced Ultrasound Evaluation of Residual Blood Flow to Hepatocellular Carcinoma After Treatment With Transarterial Chemoembolization Using Drug\u2010Eluting Beads"],"prefix":"10.1002","volume":"34","author":[{"given":"Colette M.","family":"Shaw","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Eisenbrey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrej","family":"Lyshchik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick 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