{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:06:18Z","timestamp":1791266778298,"version":"4.1.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background and aim:<\/jats:title>\n                    <jats:p>Irritable bowel syndrome (IBS) is referred to as a functional bowel disorder which is diagnosed by a number of characteristic symptoms (Rome II criteria) in the absence of detectable structural abnormalities. Low-grade inflammation of the intestine may be one of the reasons for development of diarrhoea-predominant IBS (IBS-D). We undertook this study to estimate the serum levels of pro-inflammatory (IL-6, TNF-\u03b1) and anti-inflammatory (IL-10) cytokines in IBS-D patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 108 diarrhoea patients were screened. Out of these only 63 adult IBS-D patients were enrolled. Age and sex matched 62 apparently healthy controls with no GI symptoms were also recruited. Out of 63 IBS-D patients, 37 were males while there were 32 males among the controls. The patients with IBS-D were diagnosed according to the Rome II criteria. Levels of serum IL-6, TNF-\u03b1 and IL-10 were measured in all subjects using ELISA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Mean (\u00b1SD) age of IBS-D patients (42.6\u00b119.5 years) was comparable (p=0.64) to that of controls (43.5\u00b118.7 years). The mean (\u00b1SD) levels of IL-6 in IBS-D patients (32.2\u00b112.01pg\/ ml) was significantly higher (p&lt;0.001) than in controls (7.48\u00b12.55pg\/ml). The levels of TNF-\u03b1 in IBS-D patients (16.3\u00b15.2 pg\/ml) were also significantly higher (p&lt;0.05) than in controls (7.94\u00b12.19 pg\/ml). There was no significant difference in the serum levels of IL-10 (p=0.23) between IBS-D patients (5.75\u00b12.1 pg\/ml) and controls (5.84\u00b11.9 pg\/ml).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our results indicate that mild inflammation is involved in IBS-D patients as proinflammatory cytokines were increased although no difference in anti-inflammatory cytokine was observed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.7869\/tg.2012.66","type":"journal-article","created":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T04:24:57Z","timestamp":1362630297000},"page":"251-256","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":59,"title":["Pro-inflammatory and anti-inflammatory cytokine response in diarrhoea-predominant Irritable bowel syndrome patients"],"prefix":"10.4103","volume":"33","author":[{"given":"SV","family":"Rana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SK","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KK","family":"Parsad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Tropical Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00007902-201210000-00003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:36:43Z","timestamp":1787067403000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00007902-201210000-00003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.7869\/tg.2012.66","relation":{},"ISSN":["0250-636X"],"issn-type":[{"value":"0250-636X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}