{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T11:07:10Z","timestamp":1767006430682},"reference-count":56,"publisher":"Editorial Committee of Japanese Journal of Infectious Diseases, National Institute of Infectious Dis","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Jpn J Infect Dis"],"published-print":{"date-parts":[[2014]]},"DOI":"10.7883\/yoken.67.86","type":"journal-article","created":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T03:00:14Z","timestamp":1395284414000},"page":"86-94","source":"Crossref","is-referenced-by-count":9,"title":["Dengue Virus neither Directly Mediates Hyperpermeability nor Enhances Tumor Necrosis Factor-^|^alpha;-Induced Permeability In Vitro"],"prefix":"10.7883","volume":"67","author":[{"given":"Muhareva","family":"Raekiansyah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyre Anni","family":"Espada-Murao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenta","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Kubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouichi","family":"Morita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4631","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Halstead, S.B. (2007): Dengue. Lancet, 370, 1644&ndash;1652.","DOI":"10.1016\/S0140-6736(07)61687-0"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Henchal, E.A. and Putnak, J.R. (1990): The dengue viruses. Clin. Microbiol. Rev., 3, 376&ndash;396.","DOI":"10.1128\/CMR.3.4.376"},{"key":"3","unstructured":"3. Special Programme for Research and Training in Tropical Diseases\/World Health Organization (TDR\/WHO) (2009): Evaluation of commercially available anti-dengue virus immunoglobulin M tests. Diagnostics Evaluation Series No. 3. TDR\/WHO, Geneva, Switzerland."},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Rothman, A.L. and Ennis F.A. (1999): Immunopathogenesis of dengue hemorrhagic fever. Virology, 257, 1&ndash;6.","DOI":"10.1006\/viro.1999.9656"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Hunt, N.H., Golenser, J., Chan-Ling, T., et al. (2006): Immunopathogenesis of cerebral malaria. Int. J. Parasitol., 36, 569&ndash;582.","DOI":"10.1016\/j.ijpara.2006.02.016"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Steinberg, B.E., Goldenberg, N.M. and Lee W.L. (2012): Do viral infections mimic bacterial sepsis? The role of microvascular permeability: a review of mechanisms and methods. Antiviral Res., 93, 2&ndash;15.","DOI":"10.1016\/j.antiviral.2011.10.019"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Andrews, B.S., Theofilopoulos, A.N., Peters C.J., et al. (1978): Replication of dengue and junin viruses in cultured rabbit and human endothelial cells. Infect. Immun., 20, 776&ndash;781.","DOI":"10.1128\/IAI.20.3.776-781.1978"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Dalrymple, N. and Mackow, E.R. (2011): Productive dengue virus infection of human endothelial cells is directed by heparan sulfate-containing proteoglycan receptors. J. Virol., 85, 9478&ndash;9485.","DOI":"10.1128\/JVI.05008-11"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Peyrefitte, C.N., Pastorino, B., Grau, G.E., et al. (2006): Dengue virus infection of human microvascular endothelial cells from different vascular beds promotes both common and specific functional changes. J. Med. Virol., 78, 229&ndash;242.","DOI":"10.1002\/jmv.20532"},{"key":"10","unstructured":"10. Jessie, K., Fong, M.Y., Devi, S., et al. (2004): Localization of dengue virus in naturally infected human tissues, by immunohistochemistry and in site hybridization. J. Infect. Dis., 189, 1411&ndash;1418."},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Zellweger, R.M., Prestwood, T.R. and Shresta, S. (2010): Enhanced infection of liver sinusoidal endothelial cells in a mouse model of antibody-induced severe dengue disease. Cell Host Microbe, 7, 128&ndash;139.","DOI":"10.1016\/j.chom.2010.01.004"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Avirutnan, P., Malasit, P., Seliger, B., et al. (1998): Dengue virus infection of human endothelial cells leads to chemokine production, complement activation, and apoptosis. J. Immunol., 161, 6338&ndash;6346.","DOI":"10.4049\/jimmunol.161.11.6338"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Limonta, D., Cap&oacute;, V., Torres, G., et al. (2007): Apoptosis in tissues from fatal dengue shock syndrome. J. Clin. Virol., 401, 50&ndash;54.","DOI":"10.1016\/j.jcv.2007.04.024"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Dewi, B.E., Takasaki, T. and Kurane, I. (2004): In vitro assessment of human endothelial cell permeability: effects of inflammatory cytokines and dengue virus infection. J. Virol. Methods, 121, 171&ndash;180.","DOI":"10.1016\/j.jviromet.2004.06.013"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Talavera, D., Castillo, A.M., Dominguez, M.C., et al. (2004): IL8 release, tight junction and cytoskeleton dynamic reorganization conducive to permeability increase are induced by dengue virus infection of microvascular endothelial monolayers. J. Gen. Virol., 85, 1801&ndash;1813.","DOI":"10.1099\/vir.0.19652-0"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Rothman, A.L. (2011): Immunity to dengue virus: a tale of original antigenic sin and tropical cytokine storms. Nat. Rev. Immunol., 11, 532&ndash;543.","DOI":"10.1038\/nri3014"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Schmid, E.F., Binder, K., Grell, M., et al. (1995): Both tumor necrosis factor receptors, TNFR60 and TNFR80, are involved in signaling endothelial tissue factor expression by juxtacrine tumor necrosis factor &alpha;. Blood, 86, 1836&ndash;1841.","DOI":"10.1182\/blood.V86.5.1836.bloodjournal8651836"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Kinney, R.M., Butrapet, S., Chang, G.J., et al. (1997): Construction of infectious cDNA clones for dengue 2 virus: strain 16681 and its attenuated vaccine derivative, strain PDK-53. Virology, 230, 300&ndash;308.","DOI":"10.1006\/viro.1997.8500"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Okamoto, K., Kinoshita, H., Parquet Mdel, C., et al. (2012): Dengue virus strain DEN2 16681 utilizes a specific glycochain of syndecan-2 proteoglycan as a receptor. J. Gen. Virol., 93, 761&ndash;770.","DOI":"10.1099\/vir.0.037853-0"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Gavrilovskaya, I.N., Gorbunova, E.E., Mackow, N.A., et al. (2008): Hantaviruses direct endothelial cell permeability by sensitizing cells to the vascular permeability factor VEGF, while angiopoietin 1 and sphingosine 1-phosphate inhibit hantavirus-directed permeability. J. Virol., 82, 5797&ndash;5806.","DOI":"10.1128\/JVI.02397-07"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Pfaffl, M.W. (2001): A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res., 29, 2003&ndash;2007.","DOI":"10.1093\/nar\/29.9.e45"},{"key":"22","unstructured":"22. Livak, K.J. and Schmittgen, T.D. (2001): Analysis of relative gene expression data using real-time quantitative PCR and the 2<sup>&minus;&Delta;&Delta;CT<\/sup> method. Methods, 25, 402&ndash;408."},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Chagan-Yasutan, H., Ndhlovu, L.C., Lacuesta, T.L., et al. (2013): Galectin-9 plasma levels reflect adverse hematological and immunological features in acute dengue virus infection. J. Clin. Virol., 58, 635&ndash;640.","DOI":"10.1016\/j.jcv.2013.10.022"},{"key":"24","unstructured":"24. Gillies, M.C. and Su, T. (1995): Interferon-&alpha;2b enhances barrier function of bovine retinal microvascular endothelium <i>in vitro<\/i>. Microvasc. Res., 49, 277&ndash;288."},{"key":"25","unstructured":"25. Kraus, J., Ling, A.K., Hamm, S., et al. (2004): Interferon-&beta; stabilizes barrier characteristics of brain endothelial cells in vitro. Ann. Neurol., 56, 192&ndash;205."},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Warke, R.V., Xhaja, K., Martin, K.J., et al. (2003): Dengue virus induces novel changes in gene expression of human umbilical vein endothelial cells. J. Virol., 77, 11822&ndash;11832.","DOI":"10.1128\/JVI.77.21.11822-11832.2003"},{"key":"27","unstructured":"27. Hober, D., Delannoy, A.S., Benyoucef, S., et al. (1996): High levels of sTNFR p75 and TNF&alpha; in dengue-infected patients. Microbiol. Immunol., 40, 569&ndash;573."},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Bosch, I., Xhaja, K., Estevez, L., et al. (2002): Increased production of interleukin-8 in primary human monocytes and in human epithelial and endothelial cell lines after dengue virus challenge. J. Virol., 76, 5588&ndash;5597.","DOI":"10.1128\/JVI.76.11.5588-5597.2002"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Liew, K.J. and Chow, V.T. (2006): Microarray and real-time RT-PCR analyses of a novel set of differentially expressed human genes in ECV304 endothelial-like cells infected with dengue virus type 2. J. Virol. Methods, 131, 47&ndash;57.","DOI":"10.1016\/j.jviromet.2005.07.003"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Drexler, H.G., Quentmeier, H., Dirks, W.G., et al. (2002): Bladder carcinoma cell line ECV304 is not a model system for endothelial cell. In Vitro Cell. Dev. Biol. Anim., 38, 185&ndash;186.","DOI":"10.1290\/1071-2690(2002)038<0185:BCCLEI>2.0.CO;2"},{"key":"31","unstructured":"31. Azizan, A., Sweat, J., Espino, C., et al. (2006): Differential proinflammatory and angiogenesis-specific cytokine production in human pulmonary endothelial cells, HPMEC-ST1.6R infected with dengue-2 and dengue-3 virus. J. Virol. Methods, 138, 211&ndash;217."},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Azizan, A., Fitzpatrick, K., Signorovitz, A., et al. (2009): Profile of time-dependent VEGF upregulation in human pulmonary endothelial cells, HPMEC-ST1.6R infected with DENV-1, -2, -3, and -4 viruses. Virol. J., 6, 49.","DOI":"10.1186\/1743-422X-6-49"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Nooteboom, A.T., Hendriks, I., Otteh&ouml;ller., et al. (2000): Permeability characteristics of human endothelial monolayers seeded on different extracellular matrix proteins. Mediators. Inflamm., 9, 235&ndash;241.","DOI":"10.1080\/09629350020025755"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Weiss, T.L., Selleck, S.E., Reusch, M., et al. (1990): Serial subculture and relative transport of human endothelial cells in serum-free, defined conditions. In Vitro Cell. Dev. Biol., 26, 759&ndash;768.","DOI":"10.1007\/BF02623617"},{"key":"35","unstructured":"35. Ar&eacute;valo, M.T., Simpson-Haidaris, P.J., Kou, Z., et al. (2009): Primary human endothelial cells support direct but not antibody-dependent enhancement of dengue viral infection. J. Med. Virol., 8, 519&ndash;528."},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Diamond, M.S., Edgil, D., Roberts, T.G., et al. (2000): Infection of human cells by dengue virus is modulated by different cell types and viral strains. J. Virol., 74, 7814&ndash;7823.","DOI":"10.1128\/JVI.74.17.7814-7823.2000"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Klimstra, W.B., Ryman, K.D. and Johnston, R.E. (1998): Adaptation of Sindbis virus to BHK cells selects for use of heparan sulfate as an attachment receptor. J. Virol., 72, 7357&ndash;7366.","DOI":"10.1128\/JVI.72.9.7357-7366.1998"},{"key":"38","unstructured":"38. Minagar, A., Long, A., Ma, T.H., et al. (2003): Interferon (IFN)-&beta;1a and IFN-&beta;1b block IFN-&gamma;-induced disintegration of endothelial junction integrity and barrier. Endothelium, 10, 299&ndash;307."},{"key":"39","unstructured":"39. Kiss, J., Yegutkin, G.G., Koskinen, K., et al. (2007): IFN-&beta; protects from vascular leakage <i>via<\/i> up-regulation of CD73. Eur. J. Immunol., 37, 3334&ndash;3338."},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Morrell, C.N., Srivastava, K., Swaim, A., et al. (2011): Beta interferon suppresses the development of experimental cerebral malaria. Infect. Immun., 79, 1750&ndash;1758.","DOI":"10.1128\/IAI.00810-10"},{"key":"41","unstructured":"41. da Silva, A.J., Brickelmaier, M., Majeau, G.R., et al. (2002): Comparison of gene expression patterns induced by treatment of human umbilical vein endothelial cells with IFN-&alpha;2b vs. IFN-&beta;1a: understanding the functional relationship between distinct type I interferons that act through a common receptor. J. Interferon Cytokine Res., 22, 173&ndash;188."},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Narravula, S., Lennon, P.F., Mueller, B.U., et al. (2000): Regulation of endothelial CD73 by adenosine: paracrine pathway for enhanced endothelial barrier function. J. Immunol., 165, 5262&ndash;5268.","DOI":"10.4049\/jimmunol.165.9.5262"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Gomez, D. and Reich, N.C. (2003): Stimulation of primary human endothelial cell proliferation by IFN. J. Immunol., 170, 5373&ndash;5381.","DOI":"10.4049\/jimmunol.170.11.5373"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Ferrara, N. (1999): Role of vascular endothelial growth factor in the regulation of angiogenesis. Kidney Int., 56, 794&ndash;814.","DOI":"10.1007\/978-1-59259-453-5_8"},{"key":"45","unstructured":"45. Kuruganti, P.A., Hinojoza, J.R., Eaton, M.J., et al. (2002): Interferon-&beta; counteracts inflammatory mediator-induced effects on brain endothelial cell tight junction molecules&mdash;implications for multiple sclerosis. J. Neuropathol. Exp. Neurol., 61, 710&ndash;724."},{"key":"46","doi-asserted-by":"crossref","unstructured":"46. Liu, P., Woda, M., Ennis, F.A., et al. (2009): Dengue virus infection differentially regulates endothelial barrier function over time through type I interferon effects. J. Infect. Dis., 200, 191&ndash;201.","DOI":"10.1086\/599795"},{"key":"47","unstructured":"47. da Concei&ccedil;&atilde;o, T.M., Rust, N.M., Berbel, A.C., et al. (2012): Essential role of RIG-I in the activation of endothelial cells by dengue virus. Virology, 435, 281&ndash;292."},{"key":"48","unstructured":"48. McIntyre, T.M., Modur, V., Prescott, S.M., et al. (1997): Molecular mechanisms of early inflammation. Thromb. Haemost., 78, 302&ndash;305."},{"key":"49","doi-asserted-by":"crossref","unstructured":"49. Dewi, B.E., Takasaki, T. and Kurane, I. (2008): Peripheral blood mononuclear cells increase the permeability of dengue virus-infected endothelial cells in association with downregulation of vascular endothelial cadherin. J. Gen. Virol., 89, 642&ndash;652.","DOI":"10.1099\/vir.0.83356-0"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50. Huang, Y.H., Lei, H.Y., Liu, H.S., et al. (2000): Dengue virus infects human endothelial cells and induces IL-6 and IL-8 production. Am. J. Trop. Med. Hyg., 6, 71&ndash;75.","DOI":"10.4269\/ajtmh.2000.63.71"},{"key":"51","unstructured":"51. Pang, T., Cardosa, M.J. and Guzman, M.G. (2007): Of cascades and perfect storms: the immunopathogenesis of dengue haemorrhagic feverdengue shock sydnrome (DHF\/DSS). Immunol. Cell Biol., 85, 43&ndash;45."},{"key":"52","doi-asserted-by":"crossref","unstructured":"52. Juffrie, M., van Der Meer, G.M., Hack, C.E., et al. (2000): Inflammatory mediators in dengue virus infection in children: interleukin-8 and its relationship to neutrophil degranulation. Infect. Immun., 68, 702&ndash;707.","DOI":"10.1128\/IAI.68.2.702-707.2000"},{"key":"53","unstructured":"53. Luscinskas, F.W., Gerszten, R.E., Garcia-Zepeda, E.A., et al. (2000): C-C and C-X-C chemokines trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Ann. N. Y. Acad. Sci., 902, 288&ndash;293."},{"key":"54","doi-asserted-by":"crossref","unstructured":"54. Dalrymple, N.A. and Mackow, E.R. (2012): Endothelial cells elicit immune-enhancing responses to dengue virus infection. J. Virol., 86, 6408&ndash;6415.","DOI":"10.1128\/JVI.00213-12"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55. Souza, D.G., Fagundes, C.T., Sousa, L.P., et al. (2009): Essential role of platelet-activating factor receptor in the pathogenesis of dengue virus infection. Proc. Natl. Acad. Sci. USA, 106, 14138&ndash;14143.","DOI":"10.1073\/pnas.0906467106"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56. Ishii, S. and Shimizu, T. (2000): Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice. Prog. Lipid Res., 39, 41&ndash;82.","DOI":"10.1016\/S0163-7827(99)00016-8"}],"container-title":["Japanese Journal of Infectious Diseases"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T09:37:52Z","timestamp":1689068272000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/yoken\/67\/2\/67_86\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":56,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.7883\/yoken.67.86","relation":{},"ISSN":["1344-6304"],"issn-type":[{"value":"1344-6304","type":"print"}],"subject":[],"published":{"date-parts":[[2014]]}}}