{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T04:59:23Z","timestamp":1780635563097,"version":"3.54.1"},"reference-count":40,"publisher":"Editorial Committee of Japanese Journal of Infectious Diseases, National Institute of Infectious Dis","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Jpn J Infect Dis"],"published-print":{"date-parts":[[2018]]},"DOI":"10.7883\/yoken.jjid.2017.019","type":"journal-article","created":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T22:25:22Z","timestamp":1524781522000},"page":"197-204","source":"Crossref","is-referenced-by-count":14,"title":["Comparative Analysis of Immune Responses to Outer Membrane Antigens OMP10, OMP19, and OMP28 of &lt;i&gt;Brucella abortus&lt;\/i&gt;"],"prefix":"10.7883","volume":"71","author":[{"given":"Young Bin","family":"Im","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, College of Veterinary Medicine, Seoul National University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo Bin","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, College of Veterinary Medicine, Seoul National University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myunghwan","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, College of Veterinary Medicine, Seoul National University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suk","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Gyeongsang National University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han Sang","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, College of Veterinary Medicine, Seoul National University"},{"name":"Institute of Green Bio Science and Technology, Seoul National University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4631","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Foster G, Osterman BS, Godfroid J, et al. <i>Brucella ceti<\/i> sp. nov. and <i>Brucella<\/i> <i>pinnipedialis<\/i> sp. nov. for <i>Brucella<\/i> strains with cetaceans and seals as their preferred host. Int J Syst Evol Microbiol. 2007;57:2688-93.","DOI":"10.1099\/ijs.0.65269-0"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Ko J, Splitter GA. Molecular host-pathogen interaction in brucellosis: current understanding and future approaches to vaccine development for mice and humans. Clin Microbiol Rev. 2003;16:65-78.","DOI":"10.1128\/CMR.16.1.65-78.2003"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Scholz HC, N\u00f6ckler K, G\u00f6llner C, et al. <i>Brucella inopinata<\/i> sp. nov., isolated from a breast implant infection. Int J Syst Evol Microbiol. 2010;60:801-8.","DOI":"10.1099\/ijs.0.011148-0"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Whatmore AM, Davison N, Cloeckaert A, et al. <i>Brucella papionis<\/i> sp. nov., isolated from baboons (<i>Papio<\/i> spp.). Int J Syst Evol Microbiol. 2014;64:4120-8.","DOI":"10.1099\/ijs.0.065482-0"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Franco MP, Mulder M, Gilman RH, et al. Human brucellosis. Lancet Infect Dis. 2007;7:775-86.","DOI":"10.1016\/S1473-3099(07)70286-4"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Detilleux PG, Deyoe BL, Cheville NF. Entry and intracellular localization of <i>Brucella<\/i> spp. in Vero cells: fluorescence and electron microscopy. Vet Pathol. 1990;27:317-28.","DOI":"10.1177\/030098589002700503"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Detilleux PG, Deyoe BL, Cheville NF. Penetration and intracellular growth of <i>Brucella abortus<\/i> in nonphagocytic cells in vitro. Infect Immun. 1990;58:2320-8","DOI":"10.1128\/IAI.58.7.2320-2328.1990"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Kittelberger R, Bundesen PG, Cloeckaert A, et al. Serological cross-reactivity between <i>Brucella abortus<\/i> and <i>Yersinia enterocolitica<\/i> 0:9: IV. Evaluation of the M- and C-epitope antibody response for the specific detection of <i>B. abortus<\/i> infections. Vet Microbiol. 1998;60:45-57.","DOI":"10.1016\/S0378-1135(97)00202-2"},{"key":"9","unstructured":"9. O\u00f1ate AA, Vemulapalli R, Andrews E, et al. Vaccination with live <i>Escherichia coli<\/i> expressing <i>Brucella abortus<\/i> Cu\/Zn superoxide dismutase protects mice against virulent <i>B. abortus<\/i>. Infect Immun. 1999;67:986-8."},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Nielsen K, Smith P, Yu WL, et al. <i>Salmonella enterica<\/i> serotype Urbana interference with brucellosis serology. J Immunoassay Immunochem. 2007;28:289-96.","DOI":"10.1080\/15321810701454904"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Sowa BA, Kelly KA, Ficht TA, et al. SDS-soluble and peptidoglycan-bound proteins in the outer membrane-peptidoglycan complex of <i>Brucella abortus<\/i>. Vet Microbiol. 1991;27:351-69.","DOI":"10.1016\/0378-1135(91)90160-H"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Tibor A, Saman E, de Wergifosse P, et al. Molecular characterization, occurrence, and immunogenicity in infected sheep and cattle of two minor outer membrane proteins of <i>Brucella abortus<\/i>. Infect Immun. 1996;64:100-7.","DOI":"10.1128\/IAI.64.1.100-107.1996"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Kovach ME, Elzer PH, Robertson GT, et al. Cloning and nucleotide sequence analysis of a <i>Brucella abortus<\/i> gene encoding an 18 kDa immunoreactive protein. Microb Pathog. 1997;22:241-6.","DOI":"10.1006\/mpat.1996.0108"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Tibor A, Decelle B, Letesson JJ. Outer membrane proteins Omp10, Omp16, and Omp19 of <i>Brucella<\/i> spp. are lipoproteins. Infect Immun. 1999;67:4960-2.","DOI":"10.1128\/IAI.67.9.4960-4962.1999"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Sung KY, Jung M, Shin MK, et al. Induction of immune responses by two recombinant proteins of <i>Brucella abortus<\/i>, outer membrane proteins 2b porin and Cu\/Zn superoxide dismutase, in mouse model. J Microbiol Biotechnol. 2014;24:854-61.","DOI":"10.4014\/jmb.1312.12063"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Simborio HL, Lee JJ, Bernardo Reyes AW, et al. Evaluation of the combined use of the recombinant <i>Brucella abortus<\/i> Omp10, Omp19 and Omp28 proteins for the clinical diagnosis of bovine brucellosis. Microb Pathog. 2015;83-84:41-6.","DOI":"10.1016\/j.micpath.2015.05.004"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Lindler LE, Hadfield TL, Tall BD, et al. Cloning of a <i>Brucella melitensis<\/i> group 3 antigen gene encoding Omp28, a protein recognized by the humoral immune response during human brucellosis. Infect Immun. 1996;64:2490-9.","DOI":"10.1128\/IAI.64.7.2490-2499.1996"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Lim JJ, Kim DH, Lee JJ, et al. Evaluation of recombinant 28 kDa outer membrane protein of <i>Brucella abortus<\/i> for the clinical diagnosis of bovine brucellosis in Korea. J Vet Med Sci. 2012;74:687-91.","DOI":"10.1292\/jvms.11-0512"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Lim JJ, Kim DH, Lee JJ, et al. Protective effects of recombinant <i>Brucella abortus<\/i> Omp28 against infection with a virulent strain of <i>Brucella abortus<\/i> 544 in mice. J Vet Sci. 2012;13:287-92.","DOI":"10.4142\/jvs.2012.13.3.287"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Tiwari S, Kumar A, Thavaselvam D, et al. Development and comparative evaluation of a plate enzyme-linked immunosorbent assay based on recombinant outer membrane antigens Omp28 and Omp31 for diagnosis of human brucellosis. Clin Vaccine Immunol. 2013;20:1217-22.","DOI":"10.1128\/CVI.00111-13"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Gu W, Wang X, Qiu H, et al. Comparison of cytokine immune responses to <i>Brucella abortus<\/i> and <i>Yersinia enterocolitica<\/i> serotype O:9 infections in BALB\/c mice. Infect Immun. 2013;81:4392-8.","DOI":"10.1128\/IAI.00856-13"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Im YB, Park WB, Jung M, et al. Evaluation of Th1\/Th2-related immune response against recombinant proteins of <i>Brucella abortus<\/i> infection in mice. J Microbiol Biotechnol. 2016;26:1132-9.","DOI":"10.4014\/jmb.1512.12046"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Barquero-Calvo E, Martirosyan A, Ordo\u00f1ez-Rueda D, et al. Neutrophils exert a suppressive effect on Th1 responses to intracellular pathogen <i>Brucella abortus<\/i>. PLos Pathog. 2013;9:e1003167.","DOI":"10.1371\/journal.ppat.1003167"},{"key":"24","doi-asserted-by":"publisher","unstructured":"24. Hop HT, Simborio HL, Reyes AW, et al. Immunogenicity and protective effect of recombinant <i>Brucella abortus<\/i> Ndk (rNdk) against a virulent strain <i>B. abortus<\/i> 544 infection in BALB\/c mice. FEMS Microbiol Lett. 2015;362:doi: 10.1093\/femsle\/fnv003.","DOI":"10.1093\/femsle\/fnv003"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Giambartolomei GH, Zwerdling A, Cassataro J, et al. Lipoproteins, not lipopolysaccharide, are the key mediators of the proinflammatory response elicited by heat-killed <i>Brucella abortus<\/i>. J Immunol. 2004;173:4635-42.","DOI":"10.4049\/jimmunol.173.7.4635"},{"key":"26","first-page":"458","volume":"80","year":"1993","unstructured":"26. Zhan Y, Kelso A, Cheers C. Cytokine production in the murine response to brucella infection or immunization with antigenic extracts. Immunology. 1993;80:458-64.","journal-title":"Immunology","ISSN":"https:\/\/id.crossref.org\/issn\/0019-2805","issn-type":"print"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Cha SB, Rayamajhi N, Kang ML, et al. Comparative study of gamma interferon production in mice immunized with outer membrane proteins and whole bacteria of <i>Brucella abortus<\/i>. Jpn J Infect Dis. 2010;63:49-51.","DOI":"10.7883\/yoken.63.49"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Gonz\u00e1lez-Smith A, Vemulapalli R, Andrews E, et al. Evaluation of <i>Brucella abortus<\/i> DNA vaccine by expression of Cu-Zn superoxide dismutase antigen fused to IL-2. Immunobiology. 2006;211:65-74.","DOI":"10.1016\/j.imbio.2005.09.004"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Ducken DR, Brown WC, Alperin DC, et al. Subdominant outer membrane antigens in <i>Anaplasma marginale<\/i>: conservation, antigenicity, and protective capacity using recombinant protein. PLoS One. 2015;10:e0129309.","DOI":"10.1371\/journal.pone.0129309"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Hamid N, Jain SK. Characterization of an outer membrane protein of <i>Salmonella enterica<\/i> serovar typhimurium that confers protection against typhoid. Clin Vaccine Immunol. 2008;15:1461-71.","DOI":"10.1128\/CVI.00093-08"},{"key":"31","doi-asserted-by":"publisher","unstructured":"31. Li M, Li C, Song S, et al. Development and antigenic characterization of three recombinant proteins with potential for Gl\u00e4sser\u2019s disease prevention. Vaccine. 2016;34:2251-8.","DOI":"10.1016\/j.vaccine.2016.03.014"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Montero D, Orellana P, Guti\u00e9rrez D, et al. Immunoproteomic analysis to identify Shiga toxin-producing <i>Escherichia coli<\/i> outer membrane proteins expressed during human infection. Infect Immun. 2014;82:4767-77.","DOI":"10.1128\/IAI.02030-14"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Eckmann L, Kangnoff MF. Cytokines in host defense against <i>Salmonella<\/i>. Microbes Infect. 2001;3:1191-200.","DOI":"10.1016\/S1286-4579(01)01479-4"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Luo Y, O\u2019Hagan D, Zhou H, et al. Plasmid DNA encoding human carcinoembryonic antigen (CEA) adsorbed onto cationic microparticles induces protective immunity against colon cancer in CEA-transgenic mice. Vaccine. 2003;21:1938-47.","DOI":"10.1016\/S0264-410X(02)00821-6"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Boer MC, Prins C, van Meijgaarden KE, et al. <i>Mycobacterium bovis<\/i> BCG vaccination induces divergent proinflammatory or regulatory T cell responses in adults. Clin Vaccine Immunol. 2015;22:778-88.","DOI":"10.1128\/CVI.00162-15"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Hicks CA, Willi B, Riond B, et al. Protective immunity against infection with <i>Mycoplasma haemofelis<\/i>. Clin Vaccine Immunol. 2015;22:108-18.","DOI":"10.1128\/CVI.00581-14"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Zhan Y, Kelso A, Cheers C. Differential activation of <i>Brucella<\/i>-reactive CD4<sup>+<\/sup> T cells by <i>Brucella<\/i> infection or immunization with antigenic extracts. Infect Immun. 1995;63:969-75.","DOI":"10.1128\/IAI.63.3.969-975.1995"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Elenkov IJ. Glucocorticoids and the Th1\/Th2 balance. Ann N Y Acad Sci. 2004;1024:138-46.","DOI":"10.1196\/annals.1321.010"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Iwakabe K, Shimada M, Ohta A, et al. The restraint stress drives a shift in Th1\/Th2 balance toward Th2-dominant immunity in mice. Immunol Lett. 1998;62:39-43.","DOI":"10.1016\/S0165-2478(98)00021-2"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Goel D, Bhatnagar R. Intradermal immunization with outer membrane protein 25 protects Balb\/c mice from virulent <i>B. abortus<\/i> 544. Mol Immunol. 2012;51:159-68.","DOI":"10.1016\/j.molimm.2012.02.126"}],"container-title":["Japanese Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/yoken\/71\/3\/71_JJID.2017.019\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,21]],"date-time":"2022-08-21T03:25:39Z","timestamp":1661052339000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/yoken\/71\/3\/71_JJID.2017.019\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.7883\/yoken.jjid.2017.019","relation":{},"ISSN":["1344-6304","1884-2836"],"issn-type":[{"value":"1344-6304","type":"print"},{"value":"1884-2836","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}