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J Zhang Trend of epidemics and variation of pathogens of hand, foot and mouth disease in China: a dynamic series analysis, 2008-2017. Chin J Epidemiol. 2019;40:147-52. Chinese."},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Han JF, Xu S, Zhang Y, et al. Hand, foot, and mouth disease outbreak caused by coxsackievirus A6, China, 2013. J Infect. 2014;69:303-5.","DOI":"10.1016\/j.jinf.2014.03.015"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Hongyan G, Chengjie M, Qiaozhi Y, et al. Hand, foot and mouth disease caused by coxsackievirus A6, Beijing, 2013. Pediatr Infect Dis J. 2014;33:1302-3.","DOI":"10.1097\/INF.0000000000000467"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Hu YQ, Xie GC, Li DD, et al. Prevalence of coxsackievirus A6 and enterovirus 71 in hand, foot and mouth disease in Nanjing, China in 2013. Pediatr Infect Dis J. 2015;34:951-7.","DOI":"10.1097\/INF.0000000000000794"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. 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Notes from the Field: Severe Hand, Foot, and Mouth Disease Associated with Coxsackievirus A6 \u2014 Alabama, Connecticut, California, and Nevada, November 2011\u2013February 2012. MMWR (Morbidity and Mortality Wkly Rep). 2012 \/ 61(12);213-214 ."},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Anh NT, Nhu LNT, Van HMT, et al. Emerging coxsackievirus A6 causing hand, foot and mouth disease, Vietnam. Emerg Infect Dis. 2018;24:654-62.","DOI":"10.3201\/eid2404.171298"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Tan X, Li L, Zhang B, et al. Molecular epidemiology of coxsackievirus A6 associated with outbreaks of hand, foot, and mouth disease in Tianjin, China, in 2013. Arch Virol. 2015;160:1097-104.","DOI":"10.1007\/s00705-015-2340-3"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Li Y, Bao H, Zhang X, et al. Epidemiological and genetic analysis concerning the non-enterovirus 71 and non-coxsackievirus A16 causative agents related to hand, foot and mouth disease in Anyang city, Henan Province, China, from 2011 to 2015. J Med Virol. 2017;89:1749-58. Chinese.","DOI":"10.1002\/jmv.24847"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Zeng H, Lu J, Yang F, et al. The increasing epidemic of hand, foot, and mouth disease caused by coxsackievirus-A6, Guangdong, China, 2017. J Infect. 2018;76:220-3. Chinese.","DOI":"10.1016\/j.jinf.2017.11.005"},{"key":"22","unstructured":"22. Xia Y, Xu J, Dong ZF, et al. Etiological and intensive surveillance of hand\u2212foot\u2212mouth disease in Suzhou of Jiangsu Province from 2017 to 2018. J Med Pest Control. 2020;36:652-4. Chinese."},{"key":"23","unstructured":"23. Zhang GW, TZ, Liu XJ, et al. Investigation of dominant pathogen of hand, foot, and mouth disease in Luoyang from 2017 to 2018. J Mod Med Health. 2020;36:730-2. Chinese."},{"key":"24","unstructured":"24. Wang XY ZM, Sun M, Yan XF, Liu F. Epedemiology of hand\u2212foot\u2212mouth disease in Jining of Shandong Province from 2017 to 2018. Chin J Infect Dis. 2020;38:111-3."},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Upala P, Apidechkul T, Suttana W, et al. Molecular epidemiology and clinical features of hand, foot and mouth disease in northern Thailand in 2016: a prospective cohort study. BMC Infect Dis. 2018;18:630.","DOI":"10.1186\/s12879-018-3560-4"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Long L, Gao LD, Hu SX, et al. Risk factors for death in children with severe hand, foot, and mouth disease in hunan, China. Infect Dis (Lond). 2016;48:744-8.","DOI":"10.1080\/23744235.2016.1185801"},{"key":"27","unstructured":"27. Zhong X, Zhang XL, Zheng ZX, et al. Influencing factors of hand-foot-mouth diseae caused by CVA6. J Trop Med. 2015;15:696-8+707. 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