{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:38:55Z","timestamp":1787060335125,"version":"build-2736575974"},"reference-count":25,"publisher":"Editorial Committee of Japanese Journal of Infectious Diseases, National Institute of Infectious Dis","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Jpn J Infect Dis"],"published-print":{"date-parts":[[2023,11,30]]},"DOI":"10.7883\/yoken.jjid.2023.079","type":"journal-article","created":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T18:25:00Z","timestamp":1693419900000},"page":"358-364","source":"Crossref","is-referenced-by-count":2,"title":["Role of MyD88-Adaptor-Like (MAL) Gene Polymorphism rs8177374 and Cytokine (IFN-\u03b3, TNF-\u03b1, IL-10, TGF-\u03b2) Levels in Diverse Malaria Manifestations upon &lt;i&gt;P. falciparum&lt;\/i&gt; and &lt;i&gt;P. vivax&lt;\/i&gt; Infections"],"prefix":"10.7883","volume":"76","author":[{"given":"Asima","family":"Rani","sequence":"first","affiliation":[{"name":"Department of Zoology, University of Sargodha, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Kashif","family":"Nawaz","sequence":"additional","affiliation":[{"name":"Department of Zoology, University of Sargodha, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Arshad","sequence":"additional","affiliation":[{"name":"University of Education, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najma","family":"Arshad","sequence":"additional","affiliation":[{"name":"Department of Zoology, Institute of Molecular Biology and Biotechnology, Center for Research in Molecular Medicine (IMBB\/CRIMM), The University of Lahore, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4631","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Li D, Wu M. Pattern recognition receptors in health and diseases. Sig Transduct Target Ther. 2021; 6:291.","DOI":"10.1038\/s41392-021-00687-0"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Krishnegowda G, Hajjar AM, Zhu J, et al. Induction of proinflammatory responses in macrophages by the glycosylphosphatidylinositols of <i>Plasmodium falciparum<\/i>: cell signaling receptors, glycosylphosphatidylinositol (GPI) structural requirement, and regulation of GPI activity. J Biol Chem. 2005; 280: 8606-8616.","DOI":"10.1074\/jbc.M413541200"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Rajpoot S, Wary KK, Ibbott R, et al. TIRAP in the mechanism of inflammation. Front Immunol. 2021; 12:697588.","DOI":"10.3389\/fimmu.2021.697588"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Khor CC, Chapman SJ, Vannberg FO, et al. A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis. Nat Genet. 2007; 39:523-528.","DOI":"10.1038\/ng1976"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Rani A, Nawaz SK, Irfan S, et al. Role of MyD88-adaptor-like gene polymorphism rs8177374 in modulation of malaria severity in the Pakistani population. Braz J Infect Dis. 2017; 21:418-423.","DOI":"10.1016\/j.bjid.2017.04.002"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Dobbs KR, Crabtree JN, Dent AE. Innate immunity to malaria\u2014the role of monocytes. Immunol Rev. 2020; 293:8-24.","DOI":"10.1111\/imr.12830"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Popa GL, Popa MI. Recent advances in understanding the inflammatory response in malaria: a review of the dual role of cytokines. J Immunol Res. 2021; 2021:7785180.","DOI":"10.1155\/2021\/7785180"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Guliciuc M, Maier AC, Maier IM, et al. The urosepsis-A literature review. Medicina (Kaunas). 2021; 57:872.","DOI":"10.3390\/medicina57090872"},{"key":"9","unstructured":"9. World Health Organization (WHO). Disease outbreak news; malaria - Pakistan. October 17, 2022. Available at &lt;https:\/\/www.who.int\/emergencies\/disease-outbreak-news\/item\/2022-DON413&gt;. Accessed December 21, 2022."},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Hussain N. Development of rapid strip assay for typhoid, dengue and malaria. Iran J Public Health. 2021; 50:1924-1925.","DOI":"10.18502\/ijph.v50i9.7080"},{"key":"11","unstructured":"11. Menkin-Smith L, Winders WT. <i>Plasmodium vivax<\/i> Malaria. In: StatPearls [Internet]. Treasure Island: StatPearls Publishing; 2023."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Ortega-Pajares A, Rogerson SJ. The rough guide to monocytes in malaria infection. Front Immunol. 2018; 9:2888.","DOI":"10.3389\/fimmu.2018.02888"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Mahittikorn A, Mala W, Masangkay FR, et al. Increased interferon-\u03b3 levels and risk of severe malaria: a meta-analysis. Sci Rep. 2022; 12:18917.","DOI":"10.1038\/s41598-022-21965-z"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Raballah E, Kempaiah P, Karim Z, et al. CD4 T-cell expression of IFN-\u03b3 and IL-17 in pediatric malarial anemia. PLoS One. 2017; 12:e0175864.","DOI":"10.1371\/journal.pone.0175864"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Mansell A, Brint E, Gould JA, et al. Mal interacts with tumor necrosis factor receptor-associated factor (TRAF)-6 to mediate NF-\u03baB activation by Toll-like receptor (TLR)-2 and TLR4. J Biol Chem. 2004; 279:37227-37230.","DOI":"10.1074\/jbc.C400289200"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Miller LH, Baruch DI, Marsh K, et al. The pathogenic basis of malaria. Nature. 2002; 415:673-679.","DOI":"10.1038\/415673a"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Wani BA, Shehjar F, Shah S, et al. Association of IFN-gamma and IL-10 gene variants with the risk of extrapulmonary tuberculosis. Saudi J Biol Sci. 2021; 28: 4210-4216.","DOI":"10.1016\/j.sjbs.2021.06.029"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Kumar R, Ng S, Engwerda C. The role of IL-10 in malaria: a double edged sword. Front Immunol. 2019; 10:229.","DOI":"10.3389\/fimmu.2019.00229"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Hunter CA, Ellis-Neyes LA, Slifer T, et al. IL-10 is required to prevent immune hyperactivity during infection with <i>Trypanosoma cruzi<\/i>. J Immunol. 1997; 158:3311-3316.","DOI":"10.4049\/jimmunol.158.7.3311"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Guiyedi V, B\u00e9cavin C, Herbert F, et al. Asymptomatic <i>Plasmodium falciparum<\/i> infection in children is associated with increased auto-antibody production, high IL-10 plasma levels and antibodies to merozoite surface protein 3. Malar J. 2015; 14:162.","DOI":"10.1186\/s12936-015-0658-7"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Ong CH, Tham CL, Harith HH, et al. TGF-\u03b2-induced fibrosis: a review on the underlying mechanism and potential therapeutic strategies. Eur J Pharmacol. 2021; 911:174510.","DOI":"10.1016\/j.ejphar.2021.174510"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Komai T, Inoue M, Okamura T, et al. Transforming growth factor-\u03b2 and interleukin-10 synergistically regulate humoral immunity via modulating metabolic signals. Front Immunol. 2018; 9:1364.","DOI":"10.3389\/fimmu.2018.01364"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Wenisch C, Parschalk B, Burgmann H, et al. Decreased serum levels of TGF-\u03b2 in patients with acute <i>Plasmodium falciparum<\/i> malaria. J Clin Immunol. 1995; 15:69-73.","DOI":"10.1007\/BF01541734"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Ghazanfari N, Mueller SN, Heath WR. Cerebral malaria in mouse and man. Front Immunol. 2018; 9:2016.","DOI":"10.3389\/fimmu.2018.02016"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Cicchese JM, Evans S, Hult C, et al. Dynamic balance of pro- and anti-inflammatory signals controls disease and limits pathology. Immunol Rev. 2018; 285:147-167.","DOI":"10.1111\/imr.12671"}],"container-title":["Japanese Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/yoken\/76\/6\/76_JJID.2023.079\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T23:13:53Z","timestamp":1700867633000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/yoken\/76\/6\/76_JJID.2023.079\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,30]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.7883\/yoken.jjid.2023.079","relation":{},"ISSN":["1344-6304","1884-2836"],"issn-type":[{"value":"1344-6304","type":"print"},{"value":"1884-2836","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,30]]},"article-number":"JJID.2023.079"}}