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Logan LK, Weinstein RA. The epidemiology of carbapenem-resistant <i>Enterobacteriaceae<\/i>: the impact and evolution of a global menace. J Infect Dis. 2017;215:S28-S36.","DOI":"10.1093\/infdis\/jiw282"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Tamma PD, Goodman KE, Harris AD, et al. Comparing the outcomes of patients with carbapenemase-producing and non-carbapenemase-producing carbapenem-resistant <i>Enterobacteriaceae<\/i> bacteremia. Clin Infect Dis. 2017;64:257-264.","DOI":"10.1093\/cid\/ciw741"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Jean SS, Lee NY, Tang HJ, et al. Carbapenem-resistant <i>Enterobacteriaceae<\/i> infections: Taiwan aspects. Front Microbiol. 2018;9:2888.","DOI":"10.3389\/fmicb.2018.02888"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Lee CM, Liao CH, Lee WS, et al. Outbreak of <i>Klebsiella pneumoniae<\/i> carbapenemase-2-producing <i>K. pneumoniae<\/i> sequence type 11 in Taiwan in 2011. Antimicrob Agents Chemother. 2012;56:5016-5022.","DOI":"10.1128\/AAC.00878-12"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Chiu SK, Ma L, Chan MC, et al. Carbapenem nonsusceptible <i>Klebsiella pneumoniae<\/i> in Taiwan: dissemination and increasing resistance of carbapenemase producers during 2012-2015. Sci Rep. 2018;8:8468.","DOI":"10.1038\/s41598-018-26691-z"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Wu PF, Chuang C, Su CF, et al. High minimum inhibitory concentration of imipenem as a predictor of fatal outcome in patients with carbapenem non-susceptible <i>Klebsiella pneumoniae<\/i>. Sci Rep. 2016;6:32665.","DOI":"10.1038\/srep32665"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Wang CH, Ma L, Huang LY, et al. Molecular epidemiology and resistance patterns of <i>bla<\/i><sub>OXA-48<\/sub> <i>Klebsiella pneumoniae<\/i> and <i>Escherichia coli<\/i>: a nationwide multicenter study in Taiwan. J Microbiol Immunol Infect. 2021;54:665-672.","DOI":"10.1016\/j.jmii.2020.04.006"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Chen CM, Guo MK, Ke SC, et al. Emergence and nosocomial spread of ST11 carbapenem-resistant <i>Klebsiella pneumoniae<\/i> co-producing OXA-48 and KPC-2 in a regional hospital in Taiwan. J Med Microbiol. 2018;67:957-964.","DOI":"10.1099\/jmm.0.000771"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Poirel L, He\u0301ritier C, Tolu\u0308n V, et al. Emergence of oxacillinase-mediated resistance to imipenem in <i>Klebsiella pneumoniae<\/i>. Antimicrob Agents Chemother. 2004;48:15-22.","DOI":"10.1128\/AAC.48.1.15-22.2004"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Moquet O, Bouchiat C, Kinana A, et al. Class D OXA-48 carbapenemase in multidrug-resistant enterobacteria, Senegal. Emerg Infect Dis. 2011;17:143-144.","DOI":"10.3201\/eid1701.100224"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Mairi A, Pantel A, Sotto A, et al. OXA-48-like carbapenemases produce <i>Enterobacteriaceae<\/i> in different niches. Eur J Clin Microbiol Infect Dis. 2018;37:587-604.","DOI":"10.1007\/s10096-017-3112-7"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Jao YT, Wang WH, Wang A, et al. First report of OXA-48 carbapenemase-producing <i>Escherichia coli<\/i> in Taiwan. J Microbiol Immunol Infect. 2017;50:403-404.","DOI":"10.1016\/j.jmii.2016.12.003"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Khajuria A, Praharaj AK, Grover N, et al. First report of an <i>Enterobacter ludwigii<\/i> isolate coharboring NDM-1 and OXA-48 carbapenemases. Antimicrob Agents Chemother. 2013;57:5189-5190.","DOI":"10.1128\/AAC.00789-13"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Manageiro V, Ferreira E, Pinto M, et al. First description of OXA-48 carbapenemase harbored by <i>Escherichia coli<\/i> and <i>Enterobacter cloacae<\/i> from a single patient in Portugal. Antimicrob Agents Chemother. 2014;58:7613-7614.","DOI":"10.1128\/AAC.02961-14"},{"key":"15","unstructured":"15. Clinical Laboratory Standards Institute (CLSI). Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Document M07-A10. Wayne PA: CLSI; 2015."},{"key":"16","unstructured":"16. Clinical Laboratory Standards Institute (CLSI). Performance standards for antimicrobial susceptibility testing. 28th informational supplement. Document M100-S28. Wayne, PA: CLSI; 2018."},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Poirel L, Walsh TR, Cuvillier V, et al. Multiplex PCR for detection of acquired carbapenemase genes. Diagn Microbiol Infect Dis. 2011;70:119-123.","DOI":"10.1016\/j.diagmicrobio.2010.12.002"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Wu LT, Wu HJ, Chung JG, et al. Dissemination of <i>Proteus mirabilis<\/i> isolates harboring CTX-M-14 and CTX-M-3 beta-lactamases at 2 hospitals in Taiwan. Diagn Microbiol Infect Dis. 2006;54:89-94.","DOI":"10.1016\/j.diagmicrobio.2005.09.005"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Wu LT, Tsou MF, Wu HJ, et al. Survey of CTX-M-3 extended-spectrum beta-lactamase (ESBL) among cefotaxime-resistant <i>Serratia marcescens<\/i> at a medical center in middle Taiwan. Diagn Microbiol Infect Dis. 2004;49:125-129.","DOI":"10.1016\/j.diagmicrobio.2004.02.004"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Carattoli A, Bertini A, Villa L, et al. Identification of plasmids by PCR-based replicon typing. J Microbiol Methods. 2005;63:219-228.","DOI":"10.1016\/j.mimet.2005.03.018"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Tenover FC, Arbeit RD, Goering RV, et al. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. 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