{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T12:58:57Z","timestamp":1781787537875,"version":"3.54.5"},"reference-count":15,"publisher":"Editorial Committee of Japanese Journal of Infectious Diseases, National Institute of Infectious Dis","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Jpn J Infect Dis"],"published-print":{"date-parts":[[2026,5,29]]},"DOI":"10.7883\/yoken.jjid.2024.292","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T22:09:26Z","timestamp":1753913366000},"page":"115-119","source":"Crossref","is-referenced-by-count":2,"title":["A Novel Intranasal Nano-Adjuvanted Pertussis Vaccine with Enhanced Mucosal Delivery and Immunogenicity in a Rodent Model"],"prefix":"10.7883","volume":"79","author":[{"given":"Mohammad","family":"Jafari","sequence":"first","affiliation":[{"name":"Cellular and Molecular Research Center, Gerash University of Medical Sciences, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Omidvar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, Clinical Research Development Unit (CRDU), Valiasr Hospital, Birjand University of Medical Sciences, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliyar","family":"Pirouzi","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center, Gerash University of Medical Sciences, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Jahandideh","sequence":"additional","affiliation":[{"name":"Department of Research and Development, Orchidgene co, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nader","family":"Bagheri","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Amirkhani","sequence":"additional","affiliation":[{"name":"Student Research Committee, Larestan University of Medical Sciences, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atefeh","family":"Alipour","sequence":"additional","affiliation":[{"name":"Department of Nanobiotechnology, Pasteur Institute of Iran, Iran"},{"name":"Laboratory of Regenerative Medicine and Biomedical Innovations, Department of National Cell Bank, Pasteur Institute of Iran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Salmani","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center, Gerash University of Medical Sciences, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Zarrabi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Faculty of Engineering and Natural Sciences, Istinye University, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghdad","family":"Abdollahpour-Alitappeh","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Pasteur Institute of Iran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hosein","family":"Shahsavarani","sequence":"additional","affiliation":[{"name":"Laboratory of Regenerative Medicine and Biomedical Innovations, Department of National Cell Bank, Pasteur Institute of Iran, Iran"},{"name":"Department of Cell and Molecular Biology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4631","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Yeung KHT, Duclos P, Nelson EAS, et al. An update of the global burden of pertussis in children younger than 5 years: a modelling study. Lancet Infect Dis. 2017;17:974-980.","DOI":"10.1016\/S1473-3099(17)30390-0"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Buasri W, Impoolsup A, Boonchird C, et al. Construction of <i>Bordetella pertussis<\/i> strains with enhanced production of genetically-inactivated Pertussis Toxin and Pertactin by unmarked allelic exchange. BMC Microbiol. 2012;12:61.","DOI":"10.1186\/1471-2180-12-61"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Locht C, Antoine R. The History of Pertussis Toxin. Toxins (Basel). 2021;13:623.","DOI":"10.3390\/toxins13090623"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Saso A, Kampmann B, Roetynck S. Vaccine-induced cellular immunity against Bordetella pertussis: harnessing lessons from animal and human studies to improve design and testing of novel pertussis vaccines. Vaccines (Basel). 2021;9:877.","DOI":"10.3390\/vaccines9080877"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Slutter B, Jiskoot W. Dual role of CpG as immune modulator and physical crosslinker in ovalbumin loaded N-trimethyl chitosan (TMC) nanoparticles for nasal vaccination. J Control Release. 2010;148:117-121.","DOI":"10.1016\/j.jconrel.2010.06.009"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Kim CG, Kye YC, Yun CH. The Role of nanovaccine in cross-presentation of antigen-presenting cells for the activation of CD8(+) T cell responses. Pharmaceutics. 2019;11:612.","DOI":"10.3390\/pharmaceutics11110612"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Vila A, Sanchez A, Evora C, et al. PLA-PEG particles as nasal protein carriers: the influence of the particle size. Int J Pharm, 2005;292:43-52.","DOI":"10.1016\/j.ijpharm.2004.09.002"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Gutierro I, Hernandez RM, Igartua M, et al. Size dependent immune response after subcutaneous, oral and intranasal administration of BSA loaded nanospheres. Vaccine. 2002;21:67-77.","DOI":"10.1016\/S0264-410X(02)00435-8"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Najminejad H, Kalantar SM, Mokarram AR, et al. <i>Bordetella pertussis<\/i> antigens encapsulated into N-trimethyl chitosan nanoparticulate systems as a novel intranasal pertussis vaccine. Artif Cells Nanomed Biotechnol. 2019;47:2605-2611.","DOI":"10.1080\/21691401.2019.1629948"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Amini Y, Tebianian M, Mosavari N, et al. Development of an effective delivery system for intranasal immunization against <i>Mycobacterium tuberculosis<\/i> ESAT-6 antigen. Artif Cells Nanomed Biotechnol. 2017;45:291-296.","DOI":"10.3109\/21691401.2016.1146735"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Gregory AE, Titball R, Williamson D. Vaccine delivery using nanoparticles. Front Cell Infect Microbiol. 2013;3:13.","DOI":"10.3389\/fcimb.2013.00013"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Hellwig SM, van Spriel AB, Schellekens JF, et al. Immunoglobulin A-mediated protection against Bordetella pertussis infection. Infect Immun. 2001;69:4846-4850.","DOI":"10.1128\/IAI.69.8.4846-4850.2001"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Higgs R, Higgins S, Ross P, et al. Immunity to the respiratory pathogen <i>Bordetella pertussis<\/i>. Mucosal Immunol. 2012;5:485-500.","DOI":"10.1038\/mi.2012.54"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Malik A, Gupta M, Mani R, et al. Trimethyl chitosan nanoparticles encapsulated protective antigen protects the mice gainst anthrax. Front Immunol. 2018;9:562.","DOI":"10.3389\/fimmu.2018.00562"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Wang Y, Wang Y, Kang N, et al. Construction and immunological evaluation of CpG-Au@HBc virus-like nanoparticles as a potential vaccine. Nanoscale Res Lett. 2016;11:338.","DOI":"10.1186\/s11671-016-1554-y"}],"container-title":["Japanese Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/yoken\/79\/3\/79_JJID.2024.292\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T03:29:23Z","timestamp":1779506963000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/yoken\/79\/3\/79_JJID.2024.292\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,29]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.7883\/yoken.jjid.2024.292","relation":{},"ISSN":["1344-6304","1884-2836"],"issn-type":[{"value":"1344-6304","type":"print"},{"value":"1884-2836","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,29]]},"article-number":"JJID.2024.292"}}