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J Infect Dis. 1999;179:859-870.","DOI":"10.1086\/314660"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Streeck H, Maestri A, Habermann D, et al. Dissecting drivers of immune activation in chronic HIV-1 infection. EBioMedicine. 2022;83:104182.","DOI":"10.1016\/j.ebiom.2022.104182"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Deeks SG, Kitchen CMR, Liu L, et al. Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load. Blood. 2004;104:942-947.","DOI":"10.1182\/blood-2003-09-3333"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Kamat A, Misra V, Cassol E, et al. A plasma biomarker signature of immune activation in HIV patients on antiretroviral therapy. PLoS One. 2012;7:e30881.","DOI":"10.1371\/journal.pone.0030881"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Bastard JP, Fellahi S, Couffignal C, et al. Increased systemic immune activation and inflammatory profile of long-term HIV-infected ART-controlled patients is related to personal factors, but not to markers of HIV infection severity. J Antimicrob Chemother. 2015;70:1816-1824.","DOI":"10.1093\/jac\/dkv036"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Borges \u00c1H, O\u2019Connor JL, Phillips AN, et al. Factors associated with D-dimer levels in HIV-infected individuals. PLoS One. 2014;9:e90978.","DOI":"10.1371\/journal.pone.0090978"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Armah KA, McGinnis K, Baker J, et al. HIV status, burden of comorbid disease, and biomarkers of inflammation, altered coagulation, and monocyte activation. Clin Infect Dis. 2012;55:126-136.","DOI":"10.1093\/cid\/cis406"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Utay NS, Hunt PW. Role of immune activation in progression to AIDS. Curr Opin HIV AIDS. 2016;11:131-137.","DOI":"10.1097\/COH.0000000000000242"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. O\u2019Brien M, Montenont E, Hu L, et al. Aspirin attenuates platelet activation and immune activation in HIV-1-infected subjects on antiretroviral therapy: a pilot study. J Acquir Immune Defic Syndr. 2013;63:280-288.","DOI":"10.1097\/QAI.0b013e31828a292c"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Ridker PM, Buring JE, Rifai N. Soluble P-selectin and the risk of future cardiovascular events. Circulation.2001;103:491-495.","DOI":"10.1161\/01.CIR.103.4.491"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Scialla JJ, Plantinga LC, Kao WHL, et al. Soluble P-selectin levels are associated with cardiovascular mortality and sudden cardiac death in male dialysis patients. Am J Nephrol. 2011;33:224-230.","DOI":"10.1159\/000324517"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Blann AD, Nadar SK, Lip GYH. The adhesion molecule P-selectin and cardiovascular disease. Eur Heart J. 2003;24:2166-2179.","DOI":"10.1016\/j.ehj.2003.08.021"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Nkambule BB, Mxinwa V, Mkandla Z, et al. Platelet activation in adult HIV-infected patients on antiretroviral therapy: a systematic review and meta-analysis. BMC Med. 2020;18:357.","DOI":"10.1186\/s12916-020-01801-9"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Mesquita EC, Hottz ED, Amancio RT, et al. Persistent platelet activation and apoptosis in virologically suppressed HIV-infected individuals. Sci Rep. 2018;8:14999.","DOI":"10.1038\/s41598-018-33403-0"},{"key":"24","unstructured":"24. UNAIDS. The path that ends AIDS: UNAIDS global AIDS update 2023. Geneva: JointUnited Nations Programme on HIV\/AIDS; 2023."},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Mwakyandile T, Shayo G, Mugusi S, et al. Effect of aspirin on HIV disease progression among HIV-infected individuals initiating antiretroviral therapy: study protocol for a randomised controlled trial. BMJ Open. 2021;11:e049330.","DOI":"10.1136\/bmjopen-2021-049330"},{"key":"26","unstructured":"26. BD Cytometric Bead Array (CBA) Human Soluble Protein Master Buffer Kit Instruction Manual; BD Cytometric Bead Array (CBA) Human Soluble Protein Master Buffer Kit Instruction Manual. 2019."},{"key":"27","unstructured":"27. KDIGO. KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Vol. 3, IFAC Proceedings Volumes (IFAC-PapersOnline). 2013."},{"key":"28","unstructured":"28. World Health Organization. Non-communicable diseases. Fact sheets. 16 September 2023. Available at &lt;https:\/\/www.knowledge-action-portal.com\/en\/content\/noncommunicable-diseases&gt;. Accessed January 28, 2026."},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Asher I, Guri KM, Elbirt D, et al. Characteristics and outcome of patients diagnosed with HIV at older age. Medicine (Baltimore). 2016;95:e2327.","DOI":"10.1097\/MD.0000000000002327"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Eduardo E, Lamb MR, Kandula S, et al. Characteristics and outcomes among older HIV-positive adults enrolled in HIV programs in four sub-Saharan African countries. PLoS One. 2014;9:e103864.","DOI":"10.1371\/journal.pone.0103864"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Appay V, Fastenackels S, Katlama C, et al. Old age and anti-cytomegalovirus immunity are associated with altered T-cell reconstitution in HIV-1-infected patients. AIDS. 2011;25:1813-1822.","DOI":"10.1097\/QAD.0b013e32834640e6"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Singh T, Newman AB. Inflammatory markers in population studies of aging. Ageing Res Rev. 2011;10:319-329.","DOI":"10.1016\/j.arr.2010.11.002"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. 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