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Qureshi KA, Parvez A, Fahmy NA, et al. Brucellosis: Epidemiology, pathogenesis, diagnosis and treatment-a comprehensive review. Ann Med. 2023;55:2295398. https:\/\/doi.org\/10.1080\/07853890.2023.2295398","DOI":"10.1080\/07853890.2023.2295398"},{"key":"2","doi-asserted-by":"publisher","unstructured":"2. Helms AB, Balogh O, Franklin-Guild R, et al. Presumptive identification of smooth <i>Brucella<\/i> strain antibodies in canines. Front Vet Sci. 2021;8:697479. https:\/\/doi.org\/10.3389\/fvets.2021.697479","DOI":"10.3389\/fvets.2021.697479"},{"key":"3","doi-asserted-by":"publisher","unstructured":"3. Yeni DK, B\u00fcy\u00fck F, Ashraf A, et al. Tularemia: A re-emerging tick-borne infectious disease. Folia Microbiol (Praha). 2021;66(1):1-14. https:\/\/doi.org\/10.1007\/s12223-020-00827-z","DOI":"10.1007\/s12223-020-00827-z"},{"key":"4","doi-asserted-by":"publisher","unstructured":"4. Yang J, Wang Y, Hou Y, et al. Evasion of host defense by <i>Brucella<\/i>. 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Evaluation of a safranin-O-stained antigen microagglutination test for <i>Francisella tularensis<\/i> antibodies. J Clin Microbiol. 1980;11:146-148. https:\/\/doi.org\/10.1128\/jcm.11.2.146-148.1980","DOI":"10.1128\/jcm.11.2.146-148.1980"},{"key":"9","doi-asserted-by":"publisher","unstructured":"9. Yi EC, Hackett M. Rapid isolation method for lipopolysaccharide and lipid A from gram-negative bacteria. Analyst. 2000;125:651-656. https:\/\/doi.org\/10.1039\/b000368i","DOI":"10.1039\/b000368i"},{"key":"10","doi-asserted-by":"publisher","unstructured":"10. Jindan RA, Saleem N, Shafi A, et al. Clinical interpretation of detection of IgM anti-<i>Brucella<\/i> antibody in the absence of IgG and <i>Vice Versa<\/i>; a diagnostic challenge for clinicians. Pol J Microbiol. 2019;68:51-57. https:\/\/doi.org\/10.21307\/pjm-2019-006","DOI":"10.21307\/pjm-2019-006"},{"key":"11","doi-asserted-by":"publisher","unstructured":"11. Wanke MM, Delpino MV, Baldi PC. 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