{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T05:53:07Z","timestamp":1779342787392,"version":"3.51.4"},"reference-count":35,"publisher":"Editorial Committee of Japanese Journal of Infectious Diseases, National Institute of Infectious Dis","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JJMSB"],"published-print":{"date-parts":[[1994]]},"DOI":"10.7883\/yoken1952.47.211","type":"journal-article","created":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T23:02:58Z","timestamp":1395356578000},"page":"211-220","source":"Crossref","is-referenced-by-count":55,"title":["TRANS-SUPPRESSION OF GENE EXPRESSION BY HEPATITIS C VIRAL CORE PROTEIN"],"prefix":"10.7883","volume":"47","author":[{"given":"Dong Wan","family":"KIM","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosuke","family":"SUZUKI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"HARADA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izumu","family":"SAITO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"MIYAMURA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4631","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Alter, H. J., Purcell, R. H., Shih, J. W., Melpolder, J. C., Houghton, M., Choo, Q-.L, and Kuo, G. (1989) : Detection of antibody to hepatitis C virus in prospectively followed transfusion recipients with acute and chronic non-A, non-B hepatitis. N. Engl. J. Med., 321, 1494-1500.","DOI":"10.1056\/NEJM198911303212202"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Kuo, G., Choo, Q.-L., Alter, H. J., Gitnick, G. L., Redeker, A. G., Purcell, R. H., Miyamura, T., Dienstag, J. L., Alter, M. J., Stevens, C. E., Tegmeiier, G. E., Bonino, F., Colombon, M., Lee, W.-S., Kuo, C., Berger, K., Shuster, F. R., Overby, L. R., Bradley, D. W. and Houghton, M. (1989) : An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science, 244, 362-364.","DOI":"10.1126\/science.2496467"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Miyamura, T., Saito, I., Katayama, T., Kikuchi, S., Tateda, A., Houghton, M., Choo, Q.-L, and Kuo, G. (1990) : Detection of antibody against antigen expressed by molecularly cloned hepatitis C virus cDNA: application to diagnosis and blood screening for posttransfusion hepatitis. Proc. Natl. Acad. Sci. USA, 87, 983-987.","DOI":"10.1073\/pnas.87.3.983"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Saito, I., Miyamura, T., Ohbayashi, A., Harada, H., Katayama, T., Kikuchi, S., Watanabe, Y., Koi, S., Onji, M., Ohta, Y., Choo, Q.-L., Houghton, M, and Kuo, G. (1990) : Hepatitis C virus infection is associated with the development of hepatocellular carcinoma. Proc. Natl. Acad. Sci. USA, 87, 6547-6549.","DOI":"10.1073\/pnas.87.17.6547"},{"key":"5","unstructured":"5. Watanabe, Y., Harada, S., Saito, I, and Miyamura, T. (1991) : Prevalence of antibody against the core protein of hepatitis C virus in patients with hepatocellualr cartinoma. Int. J. Cancer, 48, 340-343."},{"key":"6","unstructured":"6. Bureau of Vital Statistics, Ministry of Health and Welfare, Japan (1989) : The number of cancer deaths and age-specific cancer mortality rates by site in Japan in 1987. Jpn. J. Clin. Oncol., 19, 181-193."},{"key":"7","unstructured":"7. Yoneyama, T., Takeuchi, K., Watanabe, Y., Harada, H., Ohbayashi, A., Tanaka, Y., Yuasa, T., Saito, I. and Miyamura, T. (1990) : Detection of hepatitis C virus cDNA sequence by the polymerase chain reaction in hepatocellular carcinoma tissues. Jpn. J. Med. Sci. Biol., 43, 89-94."},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Takeda, S., Shibata, M., Morishima, T., Harada, A., Nakao, A., Takagi, H. and Nagai, Y. (1992) : Hepatitis C virus infection in hepatocellular carcinoma. Cancer, 70, 2255-2259.","DOI":"10.1002\/1097-0142(19921101)70:9<2255::AID-CNCR2820700907>3.0.CO;2-N"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Kato, N., Hijikata, M., Ootsuyama, Y., Nakagawa, M., Ohkoshi, S., Sugimura, T, and Shimotohno, K. (1990) : Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis. Proc. Natl. Acad. Sci. USA, 87, 9524-9528.","DOI":"10.1073\/pnas.87.24.9524"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Choo, Q.-L., Richman, K., Han, J., Berger, K., Lee, C., Dong, C., Gallegos, C., Coit, D., Medina-Selby, A., Barr, P. J., Weiner, A. J., Bradley, D. W., Kuo, G. and Houghton, M. (1991) : Genetic organization and diversity of the hepatitis C virus. Proc. Natl. Acad. Sci. USA, 88, 2451-2455.","DOI":"10.1073\/pnas.88.6.2451"},{"key":"11","unstructured":"11. Takamizawa, A., Mori, C., Fuke, I., Manabe, S., Murakami, S., Fujita, J., Onishi, E., Andoh, T., Yoshida, I. and Okayama, H. (1991) : Structure and organization of the hepatitis C virus genome isolated from human carriers. J. Virol., 65, 1105-1113."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Miller, R. H. and Purcell, R. H. (1990) : Hepatitis C virus shares amino acid sequence similarity with pestiviruses and flaviviruses as well as members of two plant virus supergroups. Proc. Natl. Acad. Sci. USA, 87, 2057-2061.","DOI":"10.1073\/pnas.87.6.2057"},{"key":"13","unstructured":"13. Takeuchi, K., Kubo, Y., Boonmar, S., Watanabe, Y., Katayama, T., Choo, Q-L., Kuo, G., Houghton, M., Saito, I, and Miyamura, T. (1990) : Nucleotide sequence of core and envelope genes of the hepatitis C virus genome derived directly from human healthy carriers. Nucleic Acids Res., 18, 4626."},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Han, J. H., Shyamala, K. H., Richman, K. H., Brauer, M. J., Irvine, B., Urdea, M. S., Tekamp-Olson, P., Kuo, G., Choo, Q-L, and Houghton, M. (1991) : Characterization of the terminal regions of hepatitis C viral RNA: identification of conserved sequences in the 5' untranslated region and poly (A) tails at the 3' end. Proc. Natl. Acad. Sci. USA, 88, 1711-1715.","DOI":"10.1073\/pnas.88.5.1711"},{"key":"15","unstructured":"15. Okamoto, H., Okada, S., Sugiyama, Y., Yotsumoto, S., Tanaka, T., Yoshizawa, H., Tsuda, F., Miyakawa, Y. and Mayumi, M. (1990) : The 5'-terminal sequence of the hepatitis C virus genome. Jpn. J. Exp. Med., 60, 167-177."},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Houghton, M., Weiner, A., Han, J., Kuo, G. and Choo, Q.-L. (1991) : Molecular biology of the hepatitis C viruses: implications for diagnosis, development and control of viral disease. Hepatology, 14, 381-388.","DOI":"10.1002\/hep.1840140227"},{"key":"17","unstructured":"17. Harada, S., Takeuchi, K., Suzuki, T., Katayama, T., Watanabe, Y., Takebe, Y., Saito, I and Miyamura, T. (1991) : Expression of processed core protein of hepatitis C virus in mammalian cells. J. Virol., 65, 3015-3021."},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Chiba, J., Ohba, H., Matsuura, Y., Watanabe, Y., Katayama, T., Kikuchi, S., Saito, I, and Miyamura, T. (1991) : Serodiagnosis of hepatitis C virus (HCV) infection with an HCV core protein molecularly expressed by a recombinant baculovirus. Proc. Natl. Acad. Sci. USA, 88, 4641-4645.","DOI":"10.1073\/pnas.88.11.4641"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Choo, Q.-L., Kuo, G., Weiner, A. J., Overby, L. R., Bradley, D. W, and Houghton, M. (1989) : Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science, 244, 359-362.","DOI":"10.1126\/science.2523562"},{"key":"20","unstructured":"20. Tadano, M., Makino, Y., Fukunaga, T., Okuno, Y, and Fukai, K. (1989) : Detection of dengue 4 virus core protein in the nucleus. I. A monoclonal antibody to dengu 4 virus reacts with the antigen in the nucleus and cytoplasm. J. Gen. Virol., 70, 1409-1415."},{"key":"21","unstructured":"21. Suzuki, R., Ando, A., Harada, S., Matsuura, Y., Saito, I, and Miyamura, T. (1991) : Analysis of the HCV genome coding for core protein. The Third International Symposium on Viral Hepatitis and Hepatocellular Carcinoma. p.110. Taipei, Taiwan."},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Suzuki, R., Matsuura, Y., Suzuki, T., Ando, A., Chiba, J., Harada, S., Saito, I, and Miyamura, T. (1994) : Nuclear localization of the truncated hepatitis C virus core protein with its hydrophobic C-terminus deleted. J. Gen. Virol., in press.","DOI":"10.1099\/0022-1317-76-1-53"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Lo, S.-H., Selby, M., Tong, M. and Ou, J.-H. (1994) : Comparative studies of the core gene products of two different hepatitis C virus isolates: Two alternative forms determined by a single amino acid substitution. Virology, 199, 124-131.","DOI":"10.1006\/viro.1994.1104"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Takeuchi, K., Kubo, Y., Boonmar, S., Watanabe, Y., Katayama, T., Choo, Q-L., Kuo, G., Houghton, M., Saito, I, and Miyamura, T. (1990) : The putative nucleocapsid and envelope protein genes of hepatitis C virus determined by comparison of the nucleotide sequences of two isolates derived from an experimentally infected chimpanzee and healthy human carriers. J. Gen. Virol., 71, 3027-3033.","DOI":"10.1099\/0022-1317-71-12-3027"},{"key":"25","unstructured":"25. Takebe, Y., Seiki, M., Fujisawa, J., Hoy, P., Yokota, K., Arai, K., Yoshida, M, and Arai, N. (1988) : SR&alpha; promoter: an efficient and versatile mamma-lian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat. Mol. Cell. Biol., 8, 466-472."},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Graham, F. L, and Van der. Eb, A. J. (1973) : A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology, 52, 456-467.","DOI":"10.1016\/0042-6822(73)90341-3"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Kim, D.-W., Uetsuki, T., Kaziro, Y., Yamaguchi, N, and Sugano, S. (1990) : Use of the human elongation factor 1 a promoter as a versatile and efficient expression system. Gene, 91, 217-223.","DOI":"10.1016\/0378-1119(90)90091-5"},{"key":"28","unstructured":"28. Shih, C.-M., Lo, S. J., Miyamura, T., Chen, S.-Y, and Lee, Y.-H. W. (1993) : Suppression of hepatitis B virus expression and replication by hepatitis C virus core protein in HuH-7 cells. J. Virol., 67, 5823-5832."},{"key":"29","unstructured":"29. Gorman, C. M., Moffat, L. F. and Howard, B. H. (1982) : Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol., 2, 1044-1051."},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Bradford, M. M. (1976) : A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248-254.","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"31","unstructured":"31. Fujiwara, K., Ashida, K., Nishina, H., Miyajima, N., Nishizawa, M. and Ka-wai, S. (1987) : The chicken c-fos gene: cloning and nucleotide sequence analysis. J. Virol., 61, 4012-4018."},{"key":"32","unstructured":"32. Mosca, J. D. and Pitha, P. M. (1986) : Transcriptional and posttranscriptional regulation of exogenus human beta interferon gene in simian cells defective in interferon synthesis. Mol. Cell. Biol., 6, 2279-2283."},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Lee, W.-H., Bookstein, R., Hong, F., Young, L.-J., Shew, J.-Y. and Lee, E. Y.-E. (1987) : Human retinoblastoma susceptibility gene: cloning, identification, and sequence. Science, 235, 1394-1399.","DOI":"10.1126\/science.3823889"},{"key":"34","unstructured":"34. Kanei-Ishii, C. and Ishii, S. (1989) : Dual enhancer activities of the cyclic-AMP responsive element with cell type and promoter specificity. Nucleic Acids Res., 17, 1521-1536."},{"key":"35","unstructured":"35. Santolini, E., Migliaccio, G. and La Monica, N. (1994) : Biosynthesis and biochemical properties of the hepatitis C virus core protein. J. Virol., 68, 3631-3641."}],"container-title":["Japanese Journal of Medical Science and Biology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T19:17:04Z","timestamp":1565291824000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/yoken1952\/47\/4\/47_4_211\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994]]}},"URL":"https:\/\/doi.org\/10.7883\/yoken1952.47.211","relation":{},"ISSN":["0021-5112","1884-2828"],"issn-type":[{"value":"0021-5112","type":"print"},{"value":"1884-2828","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994]]}}}