{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:58:03Z","timestamp":1791349083560,"version":"4.3.1"},"reference-count":66,"publisher":"Editorial Committee of Japanese Journal of Infectious Diseases, National Institute of Infectious Dis","issue":"Supplement1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JJMSB"],"published-print":{"date-parts":[[1998]]},"DOI":"10.7883\/yoken1952.51.supplement1_s5","type":"journal-article","created":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T23:02:58Z","timestamp":1395356578000},"page":"S5-S22","source":"Crossref","is-referenced-by-count":10,"title":["The Rediscovery of Shiga Toxin and Its Role in Clinical Disease"],"prefix":"10.7883","volume":"51","author":[{"given":"Gerald T.","family":"Keusch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4631","reference":[{"key":"1","unstructured":"1. Shiga, K. (1898) : Ueber den Erreger der Dysenterie in Japan: Vorläufige Mitteilung. Zbl Bakteriol Mikrobiol Hyg 23, 599-600."},{"key":"2","unstructured":"2. Shiga, K. (1898) : Ueber den Dysenteriebacillus. Zbl Bakteriol Mikrobiol Hyg 24, 817-828."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. von Behring, E. and Kitasato, S. (1890) : Ueber das Zustandekommen der Diphtherie-Immunitat and der Tetanus-Immunitat bei thieren. Deutsche Medicinische Wochenschrift 16, 1113-1114.","DOI":"10.1055\/s-0029-1207589"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Neisser, M. and Shiga, K. (1903) : Ueber freie Receptoren von Typhus- und Dysenteriebazillen und über das Dysenterietoxin. Deutsche Medicinische Wochenschrift 29, 61.","DOI":"10.1055\/s-0028-1138255"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Conradi, H. (1903) : Ueber lösliche, durch aseptische Autolyse erhaltene Giftstoffe von Ruhr- und Typhusbazillen. Deutsche Medicinische Wochenschrift 29, 26-28.","DOI":"10.1055\/s-0028-1138228"},{"key":"6","unstructured":"6. Bessau, G. (1911) : Ueber die Dysenteriegifte and ihrer Antikörper. Zentbl. Bakt. Parasit Kde Abt I Orig 57, L27-56."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Shiga, K. (1936) : The trend of prevention, therapy and epidemiology of dysentery since the discovery of its causative organism. New Eng J Med 215, 1205-1211.","DOI":"10.1056\/NEJM193612242152602"},{"key":"8","unstructured":"8. Boivin, A. and Mesrobeanu, L. (1937) : Recherches sur les toxines des bacilles dysenteriques: sur l'xistence d'un principe toxique thermolabile et neurotrope dans les corps bacteriens du Bacille de Shiga. Compte Rendu Soc Biol 126, 222-225."},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Dubos, R.J. and Geiger, J.W. (1946) : Preparation and properties of Shiga toxin and toxoid. J Exp Med 84, 143-156.","DOI":"10.1084\/jem.84.2.143"},{"key":"10","unstructured":"10. Mekalanos, J.J. (1993-94) : Bacterial response to host signals: analysis and applications. Harvey Lectures 89, 1-13."},{"key":"11","unstructured":"11. Van Heyningen, W.E. and Gladstone, G.P. (1953) : The neurotoxin of Shigella dysenteriae 1. Production, purification and properties of the toxin. Br. J Exp Path 34, 202-216."},{"key":"12","unstructured":"12. Bridgewater, R.A.J., Morgan, R.S., Rowson, K.E.K. and Payling-Wright, G. (1955) : The neurotoxin of Shigella shigae. Morphological and functions lesions produced in the central nervous system of rabbits. Br J Exp Path 36, 447-453."},{"key":"13","unstructured":"13. Howard, J.G. (1955) : Observations on the intoxication produced in mice and rabbits by the neurotoxin of Shigella shigae. Br 7Exp Pathol 36, 439-446."},{"key":"14","unstructured":"14. Vicari, G., Olitzki, A.L. and Olitzki, Z. (1960) : The action of the thermolabile toxin of Shigella dysenteriae on cells cultivated in vitro. Br J Exp Path 41, 179-189."},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Mata, L.J., Gangarosa, E.J., Caceres, A., Perera, D.R. and Mejicanos, M.L. (1970) : Epidemic Shiga bacillus dysentery in Central America. Etiologic investigations in Guatemala, 1969. J Infect Dis 122, 170-180.","DOI":"10.1093\/infdis\/122.3.170"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Keusch, G.T., Grady, G.F., Mata, L.J. and McIver, J.M. (1972) : The pathogenesis of Shigella diarrhea. 1 Enterotoxin production by Shigella dysenteriae I. J Clin Invest 51, 1212-1218.","DOI":"10.1172\/JCI106915"},{"key":"17","unstructured":"17. Keusch, G.T., Grady, G.F., Takeuchi, A. and Sprinz, H. (1972) : The pathogenesis of Shigella diarrhea. 2. Enterotoxin induced acute enteritis in rabbitileum. J. Infect. Dis. 126, 92-95."},{"key":"18","unstructured":"18. Keusch, G.T. and Jacewicz, M. (1975) : Pathogenesis of Shigella diarrhea. V. Relationship of Shiga enterotoxin, neurotoxin and cytotoxin. J Infect Dis 131, S33-S39."},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Olsnes, S. and Eiklid, K. (1980) : Isolation and characterization of Shigella shigae cytotoxin. J Biol Chem 255, 284-289.","DOI":"10.1016\/S0021-9258(19)86295-6"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. O'Brien, A.D., LaVeck, G.D., Griffin, D.E. and Thompson, M.R. (1980) : Characterization of Shigella dysenteriae 1 (Shiga) toxin purified by anti-Shiga toxin affinity chromatography. Infect Immun 30, 170-179.","DOI":"10.1128\/IAI.30.1.170-179.1980"},{"key":"21","unstructured":"21. Donohue-Rolfe, A., Keusch, G.T., Edson, C., ThorleyLawson, D. and Jacewicz, M. (1984) : Pathogenesis of Shigella diarrhea. IX. Simplified high yield purifica-tion of Shigella toxin and characterization of subunit composition and function by the use of subunit specific monoclonal and polyclonal antibodies. J. Exp. Med. 160, 1767-1781."},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Keusch, G.T., Jacewicz, M., Levine, M.M., Hornick, R. and Kochwa, S. (1976) : Pathogenesis of Shigella diarrhea. Serum anti-cytotoxin antibody response produced by toxigenic and “non-toxigenic” S. dysenteriae 1. J Clin Invest 57, 194-202.","DOI":"10.1172\/JCI108259"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Keusch, G.T. and Jacewicz, M. (1977) : Pathogenesis of Shigella diarrhea. VII. Evidence for a cell membrane toxin receptor involving β1 linked Nacetylglucosamine. J Exp Med 146, 535-542.","DOI":"10.1084\/jem.146.2.535"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Konowalchuk, J., Speirs, J.L. and Stavric, S. (1977) : Vero response to acytotoxin of Escherichia coli. Infect Immun 18, 775-779.","DOI":"10.1128\/IAI.18.3.775-779.1977"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Koster, F., Levin, J., Walker, L., Tung, KS., Gilman, R.H., Rahaman, M.M., Majid, M.A., Islam, S. and Williams, R.C. Jr. (1978) : Hemolytic-uremic syndrome after shigellosis. New Engl J Med 298, 927-933.","DOI":"10.1056\/NEJM197804272981702"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Riley, L.W., Remis, R.S., Helgerson, S.D., McGee, H.B., Wells, J.G., Davis, B.R., Hebert, R.J., Olcott, E.S., Johnson, L.M., Hargrett, N.T., Blake, P.A. and Cohen, M.L. (1983) : Hemorrhagic colitis associated with a rare Escherichia coli serotype. New Eng J Med 308, 681-685.","DOI":"10.1056\/NEJM198303243081203"},{"key":"27","unstructured":"27. O'Brien, A.D., Lively, T.A., Chen, M.E., Rothman, S.W. and Formal, S.B. (1983) : Escherichia coli O 157: H7 strains associated with hemorrhagic colitis in the United States produce a Shigella dysenteriae I (Shiga) -like cytotoxin. Lancet I: 702."},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Strockbine, N.A., Marques, L.R., Newland, J.W., Smith, H.W., Holmes, R.K. and O'Brien, A.D. (1986) : Two toxin-converting phages from Escherichia coli O157: H7 strain 933 encode antigenically distinct toxins with similar biologic activities. Infect Immun 53, 135-40.","DOI":"10.1128\/IAI.53.1.135-140.1986"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Karmali, M.A., Petric, M., Steele, B.T. and Lim, C. (1983) : Sporadic cases of haemolytic-uraemic syndrome associated with faecal cytotoxin and cytototoxin-producing Escherichia coli in stools. Lancet I: 619-620.","DOI":"10.1016\/S0140-6736(83)91795-6"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Donohue-Rolfe, A., Kelley, M., Bennish, M. and Keusch, G.T. (1986) : Enzyme-linked immunosorbant assay for shigella toxin. J Clin Microbiol 24, 65-68.","DOI":"10.1128\/JCM.24.1.65-68.1986"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Keusch, G.T., Donohue-Rolfe, A., Jacewicz, M. and Kane, A.V. (1988) : Shiga toxin production and purification. In: Methods in Enzymology, Harshman S, Ed. Volume 165. Academic Press, Orlando. pp 152-162","DOI":"10.1016\/S0076-6879(88)65025-7"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Jacewicz, M., Clausen, H., Nudelman, E., Donohue-Rolfe, A. and Keusch, G.T. (1986) : Pathogenesis of shigella diarrhea. XI. Isolation of a shigella toxin binding glycolipid fom rabbit jejunum and HeLa cells and its identification as globotriaosylceramide. J Exp Med 163, 1391-1404.","DOI":"10.1084\/jem.163.6.1391"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Lindberg, A.A., Brown, J.E., Stromberg, N., Westling-Ryd, M. and Schultz, J.E. (1987) : Identification of the carbohydrate receptor for Shiga toxin produced by Shigella dysenteriae type 1. J Biol Chem 262, 1779-85.","DOI":"10.1016\/S0021-9258(19)75706-8"},{"key":"34","unstructured":"34. Jacewicz, M., Feldman, H.A., Donohue-Rolfe, A. and Keusch, G.T. (1989) : Pathogenesis of shigella diarrhea. XIV. Analysis of Shiga toxin receptors on cloned HeLa cells. J. Infect. Dis 159, 881-889."},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Jacewicz, M.S., Mobassaleh, M., Gross, S.K., Balasubramanian, K.A., Daniel, P.F., Raghavan, S., McCluer, R.H. and Keusch, G.T. (1994) : Pathogenesis of Shigella diarrhea. XVII. A mammalian cell membrane glycolipid, Gb3, is required but not sufficient to confer sensitivity to Shiga toxin. J Infect Dis 169, 538-546.","DOI":"10.1093\/infdis\/169.3.538"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. DeGrandis, S., Law, H., Brunton, J., Gyles, C. and Lingwood, C.A. (1989) : Globotetraosylceramide is recognized by the pig edema disease toxin. J Biol Chem 264, 12520-12525.","DOI":"10.1016\/S0021-9258(18)63888-8"},{"key":"37","unstructured":"37. Jacewicz, M. and Keusch, G.T. (1983) : Pathogenesis of shigella diarrhea. VIII. Evidence for a translocation step in the cytotoxic action of Shiga toxin. J. Infect. Dis. 148, 844-854."},{"key":"38","unstructured":"38. Keusch, G.T. and Jacewicz, M. (1984) : Primary amines and chloroquine inhibit cytotoxic responses to Shigella toxin and permit late antibody rescue of toxin treated cells. Biochem Biophys. Res. Comm. 121, 69-78."},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Sandvig, K., Olsnes, S., Brown, J.E., Petersen, O.W. and van Deurs, B. (1989) : Endocytosis from coated pits of Shiga toxin: a glycolipid-binding protein from Shigella dysenteriae 1. J Cell Biol 108, 1331-1343.","DOI":"10.1083\/jcb.108.4.1331"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Sandvig, K., Garred, O., Prydz, K., Kozlov, J.V., Hansen, S.H. and van Deurs, B. (1992) : Retrograde transport of endocytosed Shiga toxin to the endoplasmic reticulum. Nature 358, 510-512.","DOI":"10.1038\/358510a0"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Calderwood, S.B., Auclair, F., Donohue-Rolfe, A., Keusch, G.T. and Mekalanos, J.J. (1987) : Nucleotide sequence of the ironregulated Shigalike toxin genes of Escherichia coli. Proc Nat Acad Sci (USA) 84, 4364-4368.","DOI":"10.1073\/pnas.84.13.4364"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Jackson, M.P., Newland, J.W., Holmes, R.K. and O'Brien, A.D. (1987) : Nucleotide sequence analysis of the structural genes for Shiga-like toxin I encoded by bacteriophage 933J from Escherichia coli. Microb Pathogen 2, 147-153.","DOI":"10.1016\/0882-4010(87)90106-9"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Seidah, N.G., Donohue-Rolfe, A., Lazure, C., Auclair, F., Keusch, G.T. and Chretien, M. (1986) : Complete amino acid sequence of Shigella toxin Bchain. A novel polypeptide containing 69 amino acids and one disulfide bridge. J Biol Chem 261, 13928-13931.","DOI":"10.1016\/S0021-9258(18)66961-3"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Endo, Y., Tsurugi, K., Yutsudo, T., Takeda, Y., Ogasawara, T. and Igarashi, K. (1988) : Site of action of a Vero toxin (VT2) from Escherichia coli O157: H7 and of Shiga toxin on eukaryotic ribosomes. RNA N-glycosidase activity of the toxins. Eur J Biochem 171. 45-50.","DOI":"10.1111\/j.1432-1033.1988.tb13756.x"},{"key":"45","unstructured":"45. Acheson, D.W.K., Donohue-Rolfe, A. and Keusch, G.T. (1991) : The Family of Shiga and Shiga-like Toxins. In: Sourcebook of Bacterial Protein Toxins, Alouf JE, Freer JH, Eds. Academic Press, London, pp.415-433"},{"key":"46","unstructured":"46. Calderwood, S.B., Acheson, D.W.K., Keusch, G.T., Barrett, T.J., Griffin, P.M., Strockbine, N.A., Swaminathan, B., Kaper, J.B., Levine, M.M., Kaplan, B.S., Karch, H., O'Brien, A.D., Obrig, T.G., Tarr, P.I., Takeda, Y. and Wachsmuth, I.K. (1996) : Proposed new nomenclature for Shiga-like toxin (verotoxin) family. ASM News 62, 118-119."},{"key":"47","doi-asserted-by":"crossref","unstructured":"47. Garred, O., van Deurs, B. and Sandvig, K. (1995) : Furin-induced cleavage and activation of Shiga toxin. J Biol Chem 270, 10817-10821.","DOI":"10.1074\/jbc.270.18.10817"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48. Garred, O., Dubinina, E., Polesskaya, A., Olsnes, S., Kozlov, J. and Sandvig, K. (1997) : Role of the disulfide bond in Shiga toxin A-chain for toxin entry into cells. J Biol Chem 272, 11414-11419.","DOI":"10.1074\/jbc.272.17.11414"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49. Jacewicz, M.S., Mobassaleh, M., Gross, S.K., Balasubramanian, K.A., Daniel, P.F., Raghavan, S., McCluer, R.H. and Keusch, G.T. (1994) : Pathogenesis of Shigella diarrhea: XVII. A mammalian cell membrane glycolipid, Gb3, is required but not sufficient to confer sensitivity to Shiga toxin. J Infect Dis 169, 538-546.","DOI":"10.1093\/infdis\/169.3.538"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50. Sandvig, K., Garred, O. and van Deurs, B. (1997) : Intracellular transport and processing of protein toxins produced by enteric bacteria. Adv Exp Med Biol 412, 225-232.","DOI":"10.1007\/978-1-4899-1828-4_34"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51. Fraser, M.E., Chernaia, M.M., Kozlov, Y.V. and James, M.N. (1994) : Crystal structure of the holotoxin from Shigella dysenteriae at 2.5 A resolution. Nature Struct Biol 1, 59-64.","DOI":"10.1038\/nsb0194-59"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52. Stein, P.E., Boodhoo, A., Tyrrell, G.J., Brunton, J.L. and Read, R.J. (1992) : Crystal structure of the cell-binding B oligomer of verotoxin-1 from E. coli Nature 355, 748-750.","DOI":"10.1038\/355748a0"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53. Nyholm, P.G., Magnusson, G., Zheng, Z., Norel, R., Binnington-Boyd, B. and Lingwood, C.A. (1996) : Two distinct binding sites for globotriaosyl ceramide on verotoxins: identification by molecular modelling and confirmation using deoxy analogues and a new glycolipid receptor for all verotoxins. Chem Biol 3, 263-275.","DOI":"10.1016\/S1074-5521(96)90106-4"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54. Obrig, T.G., Del Vecchio, P.J., Brown, J.E., Moran, T.P., Rowland, B.M., Judge, T.K. and Rothman, S.W. (1988) : Direct cytotoxic action of Shiga toxin on human vascular endothelial cells. Infect Immun 56, 2373-2378.","DOI":"10.1128\/IAI.56.9.2373-2378.1988"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55. Louise, C.B. and Obrig, T.G. (1992) : Shiga toxin-associated hemolytic uremic syndrome: combined cytotoxic effects of shiga toxin and lipopolysaccharide (endotoxin) on human vascular endothelial cells in vitro. Infect Immun 60, 1536-1543.","DOI":"10.1128\/IAI.60.4.1536-1543.1992"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56. Louise, C.B. and Obrig, T.G. (1991) : Shiga toxin-associated hemolytic-uremic syndrome: combined cytotoxic effects of Shiga toxin, interleukin-1 beta, and tumor necrosis factor alpha on human vascular endothelial cells in vitro. Infect Immun 59, 4173-4179.","DOI":"10.1128\/IAI.59.11.4173-4179.1991"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57. Keusch, G.T., Acheson, D.W.K., Aaldering, L., Erban, J. and Jacewicz, M.S. (1996) : Comparison of the effects of Shiga-like toxin 1 on cytokine-and butyrate-treated human umbilical and saphenous vein endothelial cells. J Infect Dis 173, 1164-1170.","DOI":"10.1093\/infdis\/173.5.1164"},{"key":"58","doi-asserted-by":"crossref","unstructured":"58. Obrig, T.G., Louise, C.B., Lingwood, C.A., Boyd, B., Barley-Maloney, L. and Daniel, T.O. (1993) : Endothelial heterogeneity in Shiga toxin receptors and responses. J Biol Chem 268, 15484-15488.","DOI":"10.1016\/S0021-9258(18)82282-7"},{"key":"59","unstructured":"59. Jacewicz, M., Acheson, D.W.K., West, G.A., Lincicome, L., Binion, D.G., Fiocchi, Keusch, G.T.: Intestinal microvascular endothelial cells are highly sensitive to Shiga toxins. Submitted"},{"key":"60","doi-asserted-by":"crossref","unstructured":"60. Louise, C.B., Tran, M.C. and Obrig, T.G. (1997) : Sensitization of human umbilical vein endothelial cells to Shiga toxin: involvement of protein kinase C and NF-kappa B. Infect Immun 65, 3337-3344.","DOI":"10.1128\/IAI.65.8.3337-3344.1997"},{"key":"61","unstructured":"61. Keusch, G.T. (1977) : Bacterial toxins as virulence factors: Shiga bacillus dysentery viewed as a toxinosis. The Mt Sinai J Med 44, 33-41."},{"key":"62","doi-asserted-by":"crossref","unstructured":"62. Armstrong, G.D., Rowe, P.C., Goodyer, P., Orrbine, E., Klassen, T.P., Wells, G., MacKenzie, A., Lior, H., Blanchard, C. and Auclair, F. (1995) : A phase I study of chemically synthesized verotoxin (Shiga-like toxin) Pk-trisaccharide receptors attached to chromosorb for preventing hemolytic-uremic syndrome. J Infect Dis 171, 1042-1055.","DOI":"10.1093\/infdis\/171.4.1042"},{"key":"63","doi-asserted-by":"crossref","unstructured":"63. Germani, Y., Soro, B., Vohito, M., Morel, O. and Morvan, J. (1997) : Lancet 349, 1670.","DOI":"10.1016\/S0140-6736(05)62636-0"},{"key":"64","doi-asserted-by":"crossref","unstructured":"64. Kim, K.H., Suh, I.S., Kim, J.M., Kim, C.W. and Cho, Y.J. (1989) : Etiology of childhood diarrhea in Korea. J Clin Micro 27, 1192-1196.","DOI":"10.1128\/JCM.27.6.1192-1196.1989"},{"key":"65","doi-asserted-by":"crossref","unstructured":"65. Bhimma, R., Rollins, N.C., Coovadia, H.M. and Adhikari, M. (1997) : Postdysenteric hemolytic uremic syndrome in children during an epidemic of Shigella dysentery in Kwazulu\/Natal. Pediatric Nephrol 11, 560-564.","DOI":"10.1007\/s004670050338"},{"key":"66","unstructured":"66. Keusch, G.T., Acheson, D.W.K., Marchant, C. and McIver, J. (1998) : Toxoid based active and passive immunization to prevent and\/or modulate hemolyticuremic syndrome due to Shiga toxin producing Escherichia coli. VTEC97. Am Soc Microbiol, Washington DC, pp.409-418."}],"container-title":["Japanese Journal of Medical Science and Biology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T17:44:38Z","timestamp":1648662278000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/yoken1952\/51\/Supplement1\/51_Supplement1_S5\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998]]},"references-count":66,"journal-issue":{"issue":"Supplement1","published-print":{"date-parts":[[1998]]}},"URL":"https:\/\/doi.org\/10.7883\/yoken1952.51.supplement1_s5","relation":{},"ISSN":["0021-5112","1884-2828"],"issn-type":[{"value":"0021-5112","type":"print"},{"value":"1884-2828","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998]]}}}