{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:26:00Z","timestamp":1789568760886,"version":"build-2803163510"},"reference-count":51,"publisher":"The University of Occupational and Environmental Health, Japan","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J UOEH"],"published-print":{"date-parts":[[2015]]},"DOI":"10.7888\/juoeh.37.245","type":"journal-article","created":{"date-parts":[[2015,12,12]],"date-time":"2015-12-12T17:04:55Z","timestamp":1449939895000},"page":"245-253","source":"Crossref","is-referenced-by-count":58,"title":["Chronic Psychological Stress as a Risk Factor of Osteoporosis"],"prefix":"10.7888","volume":"37","author":[{"given":"Kagaku","family":"AZUMA","sequence":"first","affiliation":[{"name":"Department of Anatomy, School of Medicine, University of Occupational and Environmental Health, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"ADACHI","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Medicine, University of Occupational and Environmental Health, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruki","family":"HAYASHI","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Medicine, University of Occupational and Environmental Health, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kin-Ya","family":"KUBO","sequence":"additional","affiliation":[{"name":"Seijoh University Graduate School of Health Care Studies, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4637","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Rachner TD, Khosla S &amp; Hofbauer LC (2011): Osteoporosis: now and the future. Lancet 377: 1276-1287","DOI":"10.1016\/S0140-6736(10)62349-5"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Chen H, Hayashi T, Zhou X, Fujita H, Onozuka M &amp; Kubo KY (2012): Sophisticated imaging technology in the assessment of osteoporosis risk. <i>In<\/i>: Osteoporosis. (Dionyssiotis Y, <i>ed<\/i>) InTech, Rijeka pp 181-194","DOI":"10.5772\/29036"},{"key":"3","unstructured":"3. National Institutes of Health Office of the Direction (2000): Osteoporosis prevention, diagnosis, and therapy. NIH Consensus Statement 17: 1-45"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Kvetnansky R, Lu X &amp; Ziegler MG (2013): Stress-triggered changes in peripheral catecholaminergic systems. Adv Pharmacol 68: 359-397","DOI":"10.1016\/B978-0-12-411512-5.00017-8"},{"key":"5","unstructured":"5. Selye H (1975): Stress and distress. Compr Ther 1: 9-13"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Schulz A &amp; V\u00f6gele C (2015): Interoception and stress. Front Psychol 6: 993","DOI":"10.3389\/fpsyg.2015.00993"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Oakley RH &amp; Cidlowski JA (2013): The biology of the glucocorticoid receptor: new signaling mechanisms in health and disease. J Allergy Clin Immunol 132: 1033-1044","DOI":"10.1016\/j.jaci.2013.09.007"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Sapolsky RM, Romero LM &amp; Munck AU (2000): How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr Rev 21: 55-89","DOI":"10.1210\/er.21.1.55"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Marin MF, Lord C, Andrews J, Juster RP, Sindi S, Arsenault-Lapierre G, Fiocco AJ &amp; Lupien SJ (2011): Chronic stress, cognitive functioning and mental health. Neurobiol Learn Mem 96: 583-595","DOI":"10.1016\/j.nlm.2011.02.016"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Proietti R, Mapelli D, Volpe B, Bartoletti S, Sagone A, Dal Bianco L &amp; Daliento L (2011): Mental stress and ischemic heart disease: evolving awareness of a complex association. Future Cardiol 7: 425-437","DOI":"10.2217\/fca.11.13"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Cizza G, Primma S &amp; Csako G (2009): Depression as a risk factor for osteoporosis. Trends Endocrinol Metab 20: 367-373","DOI":"10.1016\/j.tem.2009.05.003"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Bab I &amp; Yirmiya R (2010): Depression, Selective Serotonin reuptake inhibitors, and osteoporosis. Curr Osteoporos Rep 8: 185-191","DOI":"10.1007\/s11914-010-0026-z"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Erez HB, Weller A, Vaisman N &amp; Kreitler S (2012): The relationship of depression, anxiety and stress with low bone mineral density in post- menopausal women. Arch Osteoporos 7: 247-255","DOI":"10.1007\/s11657-012-0105-0"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Furuzawa M, Chen H, Fujiwara S, Yamada K &amp; Kubo KY (2014): Chewing ameliorates chronic mild stress-induced bone loss in senescence-accelerated mouse (SAMP8), a murine model of senile osteoporosis. Exp Gerontol 55: 12-18","DOI":"10.1016\/j.exger.2014.03.003"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Kurahashi M, Kondo H, Iinuma M, Tamura Y, Chen H &amp; Kubo KY (2015): Tooth loss early in life accelerates age-related bone deterioration in mice. Tohoku J Exp Med 235: 29-37","DOI":"10.1620\/tjem.235.29"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Chen H, Senda T &amp; Kubo KY (2015): The osteocyte plays multiple roles in bone remodeling and mineral homeostasis. Med Mol Morphol 48: 61-68","DOI":"10.1007\/s00795-015-0099-y"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Chen H &amp; Kubo KY (2014): Bone three-dimensional microstructural features of the common osteoporotic fracture sites. World J Orthop 5: 486-495","DOI":"10.5312\/wjo.v5.i4.486"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Takeda S, Elefteriou F, Levasseur R, Liu X, Zhao L, Parker KL, Armstrong D, Ducy P &amp; Karsenty G (2002): Leptin regulates bone formation via the sympathetic nervous system. Cell 111: 305-317","DOI":"10.1016\/S0092-8674(02)01049-8"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Ducy P, Amling M, Takeda S, Priemel M, Schilling AF, Beil FT, Shen J, Vinson C, Rueger JM &amp; Karsenty G (2000): Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 100: 197-207","DOI":"10.1016\/S0092-8674(00)81558-5"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Ahima RS (2004): Body fat, leptin, and hypothalamic amenorrhea. N Engl J Med 351: 959-962","DOI":"10.1056\/NEJMp048214"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Elefteriou F, Campbell P &amp; Ma Y (2014): Control of bone remodeling by the peripheral sympathetic nervous system. Calcif Tissue Int 94: 140-151","DOI":"10.1007\/s00223-013-9752-4"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. de Vries F, Pouwels S, Bracke M, Leufkens HG, Cooper C, Lammers JW &amp; van Staa TP (2007): Use of beta-2 agonists and risk of hip \/ femur fracture: a population-based case-control study. Pharmacoepidemiol Drug Saf 16: 612-619","DOI":"10.1002\/pds.1318"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Farr JN, Charkoudian N, Barnes JN, Monroe DG, McCready LK, Atkinson EJ, Amin S, Melton LJ 3rd, Joyner MJ &amp; Khosla S (2012): Relationship of sympathetic activity to bone microstructure, turnover, and plasma osteopontin levels in women. J Clin Endocrinol Metab 97: 4219-4227","DOI":"10.1210\/jc.2012-2381"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Pasco JA, Henry MJ, Sanders KM, Kotowicz MA, Seeman E &amp; Nicholson GC (2004): Beta-adrenergic blockers reduce the risk of fracture partly by increasing bone mineral density: Geelong Osteoporosis Study. J Bone Miner Res 19: 19-24","DOI":"10.1359\/jbmr.0301214"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Song HJ, Lee J, Kim YJ, Jung SY, Kim HJ, Choi NK &amp; Park BJ (2012): \u03b21 selectivity of \u03b2-blockers and reduced risk of fractures in elderly hypertension patients. Bone 51: 1008-1015","DOI":"10.1016\/j.bone.2012.08.126"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Seibel MJ, Cooper MS &amp; Zhou H (2013): Glucocorticoid-induced osteoporosis: mechanisms, management, and future perspectives. Lancet Diabetes Endocrinol 1: 59-70","DOI":"10.1016\/S2213-8587(13)70045-7"},{"key":"27","doi-asserted-by":"crossref","unstructured":"28. Sousa DM, McDonald MM, Mikulec K, Peacock L, Herzog H, Lamghari M, Little DG &amp; Baldock PA (2013): Neuropeptide Y modulates fracture healing through Y1 receptor signaling. J Orthop Res 31: 1570-1578","DOI":"10.1002\/jor.22400"},{"key":"28","doi-asserted-by":"crossref","unstructured":"29. Brighton PJ, Szekeres PG &amp; Willars GB (2004): Neuromedin U and its receptors: structure, function, and physiological roles. Pharmacol Rev 56: 231-248","DOI":"10.1124\/pr.56.2.3"},{"key":"29","doi-asserted-by":"crossref","unstructured":"30. Sato S, Hanada R, Kimura A <i>et<\/i> <i>al<\/i> (2007): Central control of bone remodeling by neuromedin U. Nat Med 13: 1234-1240","DOI":"10.1038\/nm1640"},{"key":"30","doi-asserted-by":"crossref","unstructured":"31. Mezuk B, Eaton WW &amp; Golden SH (2008): Depression and osteoporosis: epidemiology and potential mediating pathways. Osteoporos Int 19: 1-12","DOI":"10.1007\/s00198-007-0449-2"},{"key":"31","doi-asserted-by":"crossref","unstructured":"32. Yirmiya R &amp; Bab I (2009): Major depression is a risk factor for low bone mineral density: a meta-analysis. Biol Psychiatry 66: 423-432","DOI":"10.1016\/j.biopsych.2009.03.016"},{"key":"32","doi-asserted-by":"crossref","unstructured":"33. Cizza G, Primma S, Coyle M, Gourgiotis L &amp; Csako G (2010): Depression and osteoporosis: a research synthesis with meta-analysis. Horm Metab Res 42: 467-482","DOI":"10.1055\/s-0030-1252020"},{"key":"33","doi-asserted-by":"crossref","unstructured":"34. Wu Q, Magnus JH, Liu J, Bencaz AF &amp; Hentz JG (2009): Depression and low bone mineral density: a meta-analysis of epidemiologic studies. Osteoporos Int 20: 1309-1320","DOI":"10.1007\/s00198-009-0918-x"},{"key":"34","doi-asserted-by":"crossref","unstructured":"35. Wong SY, Lau EM, Lynn H, Leung PC, Woo J, Cummings SR &amp; Orwoll E (2005): Depression and bone mineral density: is there a relationship in elderly Asian men? Results from Mr. Os (Hong Kong). Osteoporos Int 16: 610-615","DOI":"10.1007\/s00198-004-1730-2"},{"key":"35","doi-asserted-by":"crossref","unstructured":"36. Ilias I, Alesci S, Gold PW &amp; Chrousos GP (2006): Depression and osteoporosis in men: association or casual link? Hormones (Athens) 5: 9-16","DOI":"10.14310\/horm.2002.11164"},{"key":"36","doi-asserted-by":"crossref","unstructured":"37. Schweiger U, Deuschle M, K\u00f6rner A, Lammers CH, Schmider J, Gotthardt U, Holsboer F &amp; Heuser I (1994): Low lumbar bone mineral density in patients with major depression. Am J Psychiatry 151: 1691-1693","DOI":"10.1176\/ajp.151.11.1691"},{"key":"37","doi-asserted-by":"crossref","unstructured":"38. Schweiger U, Weber B, Deuschle M &amp; Heuser I (2000): Lumbar bone mineral density in patients with major depression: evidence of increased bone loss at follow-up. Am J Psychiatry 157: 118-120","DOI":"10.1176\/ajp.157.1.118"},{"key":"38","doi-asserted-by":"crossref","unstructured":"39. Esel E, Ozsoy S, Tutus A, Sofuoglu S, Kartalci S, Bayram F, Kokbudak Z &amp; Kula M (2005): Effects of antidepressant treatment and of gender on serum leptin levels in patients with major depression. Prog Neuropsychopharmacol Biol Psychiatry 29: 565-570","DOI":"10.1016\/j.pnpbp.2005.01.009"},{"key":"39","doi-asserted-by":"crossref","unstructured":"40. Yirmiya R, Goshen I, Bajayo A, Kreisel T, Feldman S, Tam J, Trembovler V, Csernus V, Shohami E &amp; Bab I (2006): Depression induces bone loss through stimulation of the sympathetic nervous system. Proc Natl Acad Sci U S A 103: 16876-16881","DOI":"10.1073\/pnas.0604234103"},{"key":"40","doi-asserted-by":"crossref","unstructured":"41. Michelson D, Stratakis C, Hill L, Reynolds J, Galliven E, Chrousos G &amp; Gold P (1996): Bone mineral density in women with depression. N Engl J Med 335: 1176-1181","DOI":"10.1056\/NEJM199610173351602"},{"key":"41","doi-asserted-by":"crossref","unstructured":"42. Altindag O, Altindag A, Asoglu M, Gunes M, Soran N &amp; Deveci Z (2007): Relation of cortisol levels and bone mineral density among premenopausal women with major depression. Int J Clin Pract 61: 416-420","DOI":"10.1111\/j.1742-1241.2006.01276.x"},{"key":"42","doi-asserted-by":"crossref","unstructured":"43. Elefteriou F, Ahn JD, Takeda S et al (2005): Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature 434: 514-520","DOI":"10.1038\/nature03398"},{"key":"43","doi-asserted-by":"crossref","unstructured":"44. Wong ML, Kling MA, Munson PJ et al (2000): Pronounced and sustained central hypernoradrenergic function in major depression with melancholic features: relation to hypercortisolism and corticotropin-releasing hormone. Proc Natl Acad Sci U S A 97: 325-330","DOI":"10.1073\/pnas.97.1.325"},{"key":"44","doi-asserted-by":"crossref","unstructured":"45. Manolagas SC, Kousteni S &amp; Jilka RL (2002): Sex steroids and bone. Recent Prog Horm Res 57: 385-409","DOI":"10.1210\/rp.57.1.385"},{"key":"45","doi-asserted-by":"crossref","unstructured":"46. Chrousos GP, Torpy DJ &amp; Gold PW (1998): Interactions between the hypothalamic-pituitary-adrenal axis and the female reproductive system: clinical implications. Ann Intern Med 129: 229-240","DOI":"10.7326\/0003-4819-129-3-199808010-00012"},{"key":"46","doi-asserted-by":"crossref","unstructured":"47. Retana-M\u00e1rquez S, Bonilla-Jaime H, V\u00e1zquez-Palacios G, Mart\u00ednez-Garc\u00eda R &amp; Vel\u00e1zquez-Moctezuma J (2003): Changes in masculine sexual behavior, corticosterone and testosterone in response to acute and chronic stress in male rats. Horm Behav 44: 327-337","DOI":"10.1016\/j.yhbeh.2003.04.001"},{"key":"47","doi-asserted-by":"publisher","unstructured":"48. Pietschmann P, Mechtcheriakova D, Meshcheryakova A, F\u00f6ger-Samwald U &amp; Ellinger I (2015): Immunology of Osteoporosis: A Mini-Review. Gerontology http:\/\/www.karger.com\/Article\/Pdf\/431091, DOI:10.1159\/000431091 (in press)","DOI":"10.1159\/000431091"},{"key":"48","doi-asserted-by":"crossref","unstructured":"49. Kahl KG, Rudolf S, Stoeckelhuber BM, Dibbelt L, Gehl HB, Markhof K, Hohagen F &amp; Schweiger U (2005): Bone mineral density, markers of bone turnover, and cytokines in young women with borderline personality disorder with and without comorbid major depressive disorder. Am J Psychiatry 162: 168-174","DOI":"10.1176\/appi.ajp.162.1.168"},{"key":"49","unstructured":"50. Kubo KY, Chen H &amp; Onozuka M (2013): The relationship between mastication and cognition. <i>In<\/i>: Senescence and Senescence-Related Disorders. (Wang Z &amp; Inuzuka H, <i>eds<\/i>). InTech, Rijeka pp 115-132"},{"key":"50","unstructured":"51. Kubo KY, Iinuma M &amp; Chen H (2015): Mastication as a stress-coping behavior. Biomed Res Int 2015: 876409"},{"key":"51","doi-asserted-by":"crossref","unstructured":"52. Chen H, Iinuma M, Onozuka M &amp; Kubo KY (2015): Chewing maintains hippocampus-dependent cognitive function. Int J Med Sci 12: 502-509","DOI":"10.7150\/ijms.11911"}],"container-title":["Journal of UOEH"],"original-title":["\u9aa8\u7c97\u9b06\u75c7\u306e\u5371\u967a\u56e0\u5b50\u3068\u3057\u3066\u306e\u6162\u6027\u306e\u7cbe\u795e\u7684\u30b9\u30c8\u30ec\u30b9"],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/juoeh\/37\/4\/37_245\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T07:50:35Z","timestamp":1567410635000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/juoeh\/37\/4\/37_245\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":51,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.7888\/juoeh.37.245","relation":{},"ISSN":["0387-821X","2187-2864"],"issn-type":[{"value":"0387-821X","type":"print"},{"value":"2187-2864","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}