{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T19:34:34Z","timestamp":1785008074520,"version":"3.55.0"},"reference-count":24,"publisher":"International College of Surgeons","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n        <jats:p>This single-institution experience retrospectively reviewed the outcomes in 21 patients with primary duodenal adenocarcinoma. Twelve patients underwent curative surgery, and 9 patients underwent palliative surgery at the Chiba University Hospital. The maximum follow-up period was 8650\u00a0days. All pathologic specimens from endoscopic biopsy and surgical specimens were reviewed and categorized. Twelve (57.1%) patients underwent curative surgery (R0): 4 pancreaticoduodenectomies (PD), 4 pylorus-preserving PDs (PpPD), 2 local resections of the duodenum and 2 endoscopic mucosal resections (EMR). Palliative surgery was performed for 9 patients (42.9%) following gastro-intestinal bypass. The median cause-specific survival times were 1784\u00a0days (range 160\u20138650\u00a0days) in the curative surgery group and 261\u00a0days (range 27\u2013857\u00a0days) in the palliative surgery group (<jats:italic>P<\/jats:italic> \u200a=\u200a 0.0003, log-rank test). The resectability of primary duodenal adenocarcinoma was associated with a smaller tumor size, a lower degree of tumor depth invasiveness, and less spread to the lymph nodes and distant organs.<\/jats:p>","DOI":"10.9738\/1381.1","type":"journal-article","created":{"date-parts":[[2012,12,13]],"date-time":"2012-12-13T18:35:24Z","timestamp":1355423724000},"page":"111-116","source":"Crossref","is-referenced-by-count":14,"title":["Survival Predictors of Patients With Primary Duodenal Adenocarcinoma"],"prefix":"10.9738","volume":"96","author":[{"given":"Hiroshi","family":"Kawahira","sequence":"first","affiliation":[{"name":"Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan"},{"name":"Research Center for Frontier Medical Engineering, Chiba University, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihiko","family":"Miura","sequence":"additional","affiliation":[{"name":"Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Saigo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Chiba-Higashi National Hospital, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinao","family":"Matsunaga","sequence":"additional","affiliation":[{"name":"Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Natsume","sequence":"additional","affiliation":[{"name":"Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Akai","sequence":"additional","affiliation":[{"name":"Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Horibe","sequence":"additional","affiliation":[{"name":"Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazufumi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Nabeya","sequence":"additional","affiliation":[{"name":"Division of Gastroenterological Surgery, Chiba Cancer Center Hospital, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan"},{"name":"Research Center for Frontier Medical Engineering, Chiba University, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Miyauchi","sequence":"additional","affiliation":[{"name":"Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyohiko","family":"Shuto","sequence":"additional","affiliation":[{"name":"Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehide","family":"Asano","sequence":"additional","affiliation":[{"name":"Department of Surgery, Chiba-Higashi National Hospital, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisahiro","family":"Matsubara","sequence":"additional","affiliation":[{"name":"Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4721","reference":[{"issue":"1","key":"i0020-8868-96-2-111-Sohn1","series-title":"J Gastrointest Surg","first-page":"79","article-title":"Adenocarcinoma of the duodenum: factors influencing long-term survival.","volume":"2","author":"Sohn, TA","year":"1998","unstructured":"Sohn, TA, LillemoeKD, CameronJL, PittHA, KaufmanHS, HrubanRH, et al. Adenocarcinoma of the duodenum: factors influencing long-term survival.J Gastrointest Surg1998. 2 (1):79\u201387."},{"issue":"2","key":"i0020-8868-96-2-111-Rose1","series-title":"J Am Coll Surg","first-page":"89","article-title":"Primary duodenal adenocarcinoma: a ten-year experience with 79 patients.","volume":"183","author":"Rose, DM","year":"1996","unstructured":"Rose, DM, HochwaldSN, KlimstraDS, and BrennanMF. Primary duodenal adenocarcinoma: a ten-year experience with 79 patients.J Am Coll Surg1996. 183 (2):89\u201396."},{"issue":"1","key":"i0020-8868-96-2-111-Howe1","series-title":"Ann Surg","first-page":"87","article-title":"Factors predictive of survival in ampullary carcinoma.","volume":"228","author":"Howe, JR","year":"1998","unstructured":"Howe, JR, KlimstraDS, MocciaRD, ConlonKC, and BrennanMF. Factors predictive of survival in ampullary carcinoma.Ann Surg1998. 228 (1):87\u201394."},{"issue":"12","key":"i0020-8868-96-2-111-Fong1","series-title":"Br J Surg","first-page":"1712","article-title":"Outcome of treatment for distal bile duct cancer.","volume":"83","author":"Fong, Y","year":"1996","unstructured":"Fong, Y, BlumgartLH, LinE, FortnerJG, and BrennanMF. Outcome of treatment for distal bile duct cancer.Br J Surg1996. 83 (12):1712\u20131715."},{"issue":"3","key":"i0020-8868-96-2-111-Conlon1","series-title":"Ann Surg","first-page":"273","article-title":"Long-term survival after curative resection for pancreatic ductal adenocarcinoma. Clinicopathologic analysis of 5-year survivors.","volume":"223","author":"Conlon, KC","year":"1996","unstructured":"Conlon, KC, KlimstraDS, and BrennanMF. Long-term survival after curative resection for pancreatic ductal adenocarcinoma. Clinicopathologic analysis of 5-year survivors.Ann Surg1996. 223 (3):273\u2013279."},{"key":"i0020-8868-96-2-111-Sobin1","series-title":"International Union Against Cancer (UICC): TNM Classification of Malignant Tumours. 7th ed","author":"Sobin, L","year":"2010","unstructured":"Sobin, L, GospodarowiczM, and WittekindC. International Union Against Cancer (UICC): TNM Classification of Malignant Tumours. 7th ed. New York, NYWiley-Liss. 2010."},{"issue":"10","key":"i0020-8868-96-2-111-Bakaeen1","series-title":"Arch Surg","first-page":"635","article-title":"What prognostic factors are important in duodenal adenocarcinoma?","volume":"135","author":"Bakaeen, FG","year":"2000","unstructured":"Bakaeen, FG, MurrMM, SarrMG, ThompsonGB, FarnellMB, NagorneyDM, et al. What prognostic factors are important in duodenal adenocarcinoma?Arch Surg2000. 135 (10):635\u2013641; discussion 641\u2013632."},{"issue":"10","key":"i0020-8868-96-2-111-Lee1","series-title":"World J Surg","first-page":"2246","article-title":"Prognostic factors for primary duodenal adenocarcinoma.","volume":"32","author":"Lee, HG","year":"2008","unstructured":"Lee, HG, YouDD, PaikKY, HeoJS, ChoiSH, and ChoiDW. Prognostic factors for primary duodenal adenocarcinoma.World J Surg2008. 32 (10):2246\u20132252."},{"issue":"1","key":"i0020-8868-96-2-111-Shinoda1","series-title":"Dig Endosc","first-page":"49","article-title":"Successful endoscopic submucosal dissection for mucosal cancer of the duodenum.","volume":"22","author":"Shinoda, M","year":"2010","unstructured":"Shinoda, M, MakinoA, WadaM, KabeshimaY, TakahashiT, KawakuboH, et al. Successful endoscopic submucosal dissection for mucosal cancer of the duodenum.Dig Endosc2010. 22 (1):49\u201352."},{"issue":"6","key":"i0020-8868-96-2-111-Moss1","series-title":"Arch Surg","first-page":"805","article-title":"Primary adenocarcinoma of the duodenum.","volume":"108","author":"Moss, WM","year":"1974","unstructured":"Moss, WM, McCartPM, JulerG, and MillerDR. Primary adenocarcinoma of the duodenum.Arch Surg1974. 108 (6):805\u2013807."},{"issue":"1","key":"i0020-8868-96-2-111-Jones1","series-title":"Am J Surg","first-page":"46","article-title":"Periampullary tumors: which ones should be resected?","volume":"149","author":"Jones, BA","year":"1985","unstructured":"Jones, BA, LangerB, TaylorBR, and GirottiM. Periampullary tumors: which ones should be resected?Am J Surg1985. 149 (1):46\u201352."},{"issue":"5","key":"i0020-8868-96-2-111-Lai1","series-title":"World J Surg","first-page":"695","article-title":"Primary adenocarcinoma of the duodenum: analysis of survival.","volume":"12","author":"Lai, EC","year":"1988","unstructured":"Lai, EC, DotyJE, IrvingC, and TompkinsRK. Primary adenocarcinoma of the duodenum: analysis of survival.World J Surg1988. 12 (5):695\u2013699."},{"issue":"6","key":"i0020-8868-96-2-111-Delcore1","series-title":"Am J Surg","first-page":"626","article-title":"Improving resectability and survival in patients with primary duodenal carcinoma.","volume":"166","author":"Delcore, R","year":"1993","unstructured":"Delcore, R, ThomasJH, ForsterJ, and HermreckAS. Improving resectability and survival in patients with primary duodenal carcinoma.Am J Surg1993. 166 (6):626\u2013630; discussion 630\u2013621."},{"issue":"6","key":"i0020-8868-96-2-111-Sohn2","series-title":"J Am Coll Surg","first-page":"658","article-title":"Surgical palliation of unresectable periampullary adenocarcinoma in the 1990s.","volume":"188","author":"Sohn, TA","year":"1999","unstructured":"Sohn, TA, LillemoeKD, CameronJL, HuangJJ, PittHA, and YeoCJ. Surgical palliation of unresectable periampullary adenocarcinoma in the 1990s.J Am Coll Surg1999. 188 (6):658\u2013666; discussion 666\u2013659."},{"issue":"1","key":"i0020-8868-96-2-111-Rotman1","series-title":"Br J Surg","first-page":"83","article-title":"Adenocarcinoma of the duodenum: factors influencing survival. French association for surgical research.","volume":"81","author":"Rotman, N","year":"1994","unstructured":"Rotman, N, PezetD, FagniezPL, CherquiD, CelicoutB, and LointierP. Adenocarcinoma of the duodenum: factors influencing survival. French association for surgical research.Br J Surg1994. 81 (1):83\u201385."},{"issue":"2","key":"i0020-8868-96-2-111-Sexe1","series-title":"Cancer","first-page":"251","article-title":"Incidence and treatment of periampullary duodenal cancer in the U.S. veteran patient population.","volume":"77","author":"Sexe, RB","year":"1996","unstructured":"Sexe, RB, WadeTP, VirgoKS, and JohnsonFE. Incidence and treatment of periampullary duodenal cancer in the U.S. veteran patient population.Cancer1996. 77 (2):251\u2013254."},{"issue":"2","key":"i0020-8868-96-2-111-Joesting1","series-title":"Am J Surg","first-page":"228","article-title":"Improving survival in adenocarcinoma of the duodenum.","volume":"141","author":"Joesting, DR","year":"1981","unstructured":"Joesting, DR, BeartRWJr, van HeerdenJA, and WeilandLH. Improving survival in adenocarcinoma of the duodenum.Am J Surg1981. 141 (2):228\u2013231."},{"issue":"16","key":"i0020-8868-96-2-111-Santoro1","series-title":"Hepatogastroenterology","first-page":"1157","article-title":"Primary adenocarcinoma of the duodenum: treatment and survival in 89 patients.","volume":"44","author":"Santoro, E","year":"1997","unstructured":"Santoro, E, SacchiM, ScutariF, CarboniF, and GrazianoF. Primary adenocarcinoma of the duodenum: treatment and survival in 89 patients.Hepatogastroenterology1997. 44 (16):1157\u20131163."},{"issue":"1","key":"i0020-8868-96-2-111-Alwmark1","series-title":"Ann Surg","first-page":"13","article-title":"Primary carcinoma of the duodenum.","volume":"191","author":"Alwmark, A","year":"1980","unstructured":"Alwmark, A, AnderssonA, and LassonA. Primary carcinoma of the duodenum.Ann Surg1980. 191 (1):13\u201318."},{"issue":"12","key":"i0020-8868-96-2-111-Heniford1","series-title":"Am Surg","first-page":"1165","article-title":"Primary nonampullary\/periampullary adenocarcinoma of the duodenum.","volume":"64","author":"Heniford, BT","year":"1998","unstructured":"Heniford, BT, LannittiDA, EvansP, GagnerM, and HendersonJM. Primary nonampullary\/periampullary adenocarcinoma of the duodenum.Am Surg1998. 64 (12):1165\u20131169."},{"issue":"10","key":"i0020-8868-96-2-111-ScottCoombes1","series-title":"Br J Surg","first-page":"1472","article-title":"Surgical treatment of primary duodenal carcinoma: a personal series.","volume":"81","author":"Scott-Coombes, DM","year":"1994","unstructured":"Scott-Coombes, DM and WilliamsonRC. Surgical treatment of primary duodenal carcinoma: a personal series.Br J Surg1994. 81 (10):1472\u20131474."},{"issue":"3","key":"i0020-8868-96-2-111-Sohn3","series-title":"Ann Surg","first-page":"393","article-title":"Reexploration for periampullary carcinoma: resectability, perioperative results, pathology, and long-term outcome.","volume":"229","author":"Sohn, TA","year":"1999","unstructured":"Sohn, TA, LillemoeKD, CameronJL, PittHA, HuangJJ, HrubanRH, et al. Reexploration for periampullary carcinoma: resectability, perioperative results, pathology, and long-term outcome.Ann Surg1999. 229 (3):393\u2013400."},{"issue":"4","key":"i0020-8868-96-2-111-Spira1","series-title":"Cancer","first-page":"1721","article-title":"Primary adenocarcinoma of the duodenum.","volume":"39","author":"Spira, IA","year":"1977","unstructured":"Spira, IA, GhaziA, and WolffWI. Primary adenocarcinoma of the duodenum.Cancer1977. 39 (4):1721\u20131726."},{"issue":"4","key":"i0020-8868-96-2-111-Sarela1","series-title":"Ann Surg Oncol","first-page":"380","article-title":"Adenocarcinoma of the duodenum: importance of accurate lymph node staging and similarity in outcome to gastric cancer.","volume":"11","author":"Sarela, Al","year":"2004","unstructured":"Sarela, Al, BrennanMF, KarpehMS, KlimstraD, and ConlonKC. Adenocarcinoma of the duodenum: importance of accurate lymph node staging and similarity in outcome to gastric cancer.Ann Surg Oncol2004. 11 (4):380\u2013386."}],"container-title":["International Surgery"],"original-title":[],"link":[{"URL":"https:\/\/international-surgery.kglmeridian.com\/view\/journals\/insu\/96\/2\/article-p111.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/international-surgery\/article-pdf\/96\/2\/111\/2215060\/1381_1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/international-surgery.kglmeridian.com\/downloadpdf\/journals\/insu\/96\/2\/article-p111.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/international-surgery.kglmeridian.com\/downloadpdf\/journals\/insu\/96\/2\/article-p111.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T19:06:41Z","timestamp":1751483201000},"score":1,"resource":{"primary":{"URL":"https:\/\/international-surgery.kglmeridian.com\/view\/journals\/insu\/96\/2\/article-p111.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":24,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.9738\/1381.1","relation":{},"ISSN":["0020-8868","2520-2456"],"issn-type":[{"value":"0020-8868","type":"print"},{"value":"2520-2456","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4]]}}}