{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:24:33Z","timestamp":1759335873873,"version":"3.41.0"},"reference-count":23,"publisher":"International College of Surgeons","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n        <jats:p>Intraoperative intact parathyroid hormone (iPTH) measurements have been proposed as an effective assay in surgery for primary hyperparathyroidism (PHPT). We have demonstrated the efficiency of the use of a hand-held gamma camera, eZ-SCOPE AN, with technetium-99m sestamibi (Tc-MIBI) scintigraphy for navigation surgery for PHPT. The aim of this preliminary study was to assess the possibility that the eZ-SCOPE AN can replace the measurement of intraoperative iPTH in surgery for PHPT. Sixteen consecutive patients with documented primary hyperparathyroidism underwent surgery using this compact camera. iPTH was routinely measured preoperatively and 10\u00a0minutes after the complete removal of adenoma. All patients had a well-defined parathyroid lesion identified on preoperative Tc-MIBI. The eZ-SCOPE revealed hyperfunctioning parathyroid glands in all cases. iPTH levels were decreased in all cases after the removal of adenomas. Our results suggest that this gamma camera is useful for confirming complete resection of endocrinologically active tissue in surgery for PHPT. In selective patients with scan-positive cases identified by preoperative Tc-MIBI, the eZ-SCOPE may replace the intraoperative iPTH assay in surgery for PHPT.<\/jats:p>","DOI":"10.9738\/cc138.1","type":"journal-article","created":{"date-parts":[[2012,10,25]],"date-time":"2012-10-25T15:57:41Z","timestamp":1351180661000},"page":"99-103","source":"Crossref","is-referenced-by-count":3,"title":["Could the eZ-SCOPE AN Gamma Camera Replace Intraoperative Measurement of iPTH for PHPT?"],"prefix":"10.9738","volume":"97","author":[{"given":"Takaaki","family":"Fujii","sequence":"first","affiliation":[{"name":"Department of General Surgical Science, Graduate School of Medicine, Gunma University, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reina","family":"Yajima","sequence":"additional","affiliation":[{"name":"Department of General Surgical Science, Graduate School of Medicine, Gunma University, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"First Department of Surgery, Graduate School of Medicine, Dokkyo University, Tochigi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soichi","family":"Tsutsumi","sequence":"additional","affiliation":[{"name":"Department of General Surgical Science, Graduate School of Medicine, Gunma University, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Asao","sequence":"additional","affiliation":[{"name":"Department of General Surgical Science, Graduate School of Medicine, Gunma University, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Kuwano","sequence":"additional","affiliation":[{"name":"Department of General Surgical Science, Graduate School of Medicine, Gunma University, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4721","reference":[{"issue":"5","key":"i0020-8868-97-2-99-Harrison1","series-title":"Langenbecks Arch Surg","first-page":"799","article-title":"Intraoperative adjuncts in surgery for primary hyperparathyroidism.","volume":"394","author":"Harrison\n              BJ","year":"2009","unstructured":"Harrison\n              BJ\n             and TriponezF. Intraoperative adjuncts in surgery for primary hyperparathyroidism.Langenbecks Arch Surg2009. 394 (5):799\u2013809."},{"issue":"suppl 1","key":"i0020-8868-97-2-99-Fujii1","series-title":"Biomed Pharmacother","first-page":"7S","article-title":"Sestamibi scintigraphy for the application of minimally invasive surgery of hyperfunctioning parathyroid lesions.","volume":"56","author":"Fujii\n              H","year":"2002","unstructured":"Fujii\n              H\n             and KuboA. Sestamibi scintigraphy for the application of minimally invasive surgery of hyperfunctioning parathyroid lesions.Biomed Pharmacother2002. 56 (suppl 1):7S\u201313S."},{"issue":"2","key":"i0020-8868-97-2-99-Rubello1","series-title":"Panminerva Med","first-page":"99","article-title":"Minimally invasive (99m) Tc-sestamibi radioguided surgery of parathyroid adenomas.","volume":"47","author":"Rubello\n              D","year":"2005","unstructured":"Rubello\n              D\n            , GiannimiS, De CarioE, et al. Minimally invasive (99m) Tc-sestamibi radioguided surgery of parathyroid adenomas.Panminerva Med2005. 47 (2):99\u2013107."},{"key":"i0020-8868-97-2-99-Twigt1","series-title":"Am J Surg","article-title":"The additional value of intraoperative parathyroid hormone assessment is marginal in patients with nonfamilial primary hyperparathyroidism: a prospective cohort study.","author":"Twigt\n              BA","year":"2011","unstructured":"Twigt\n              BA\n            , van DalenT, VollebregtAM, KortlandtW, VriensMR, and Borel RinkesIH. The additional value of intraoperative parathyroid hormone assessment is marginal in patients with nonfamilial primary hyperparathyroidism: a prospective cohort study.Am J Surg2011. Equb ahead of print. http:\/\/dx.doi.org\/10.1016\/j.amjsurg.2011.07.017."},{"issue":"11","key":"i0020-8868-97-2-99-Sugino1","series-title":"Endocr J","first-page":"953","article-title":"Minimally invasive surgery for primary hyperparathyroidism with or without intraoperative parathyroid hormone monitoring.","volume":"57","author":"Sugino\n              K","year":"2010","unstructured":"Sugino\n              K\n            , ItoK, NagahamaM, KitagawaW, ShibuyaH, OhkuwaK, et al. Minimally invasive surgery for primary hyperparathyroidism with or without intraoperative parathyroid hormone monitoring.Endocr J2010. 57 (11):953\u2013958."},{"issue":"4","key":"i0020-8868-97-2-99-Chen1","series-title":"Surgery","first-page":"587","article-title":"Intraoperative parathyroid hormone testing improves cure rates in patients undergoing minimally invasive parathyroidectomy.","volume":"138","author":"Chen\n              H","year":"2005","unstructured":"Chen\n              H\n            , PruhsZ, StarlingJR, and MackE. Intraoperative parathyroid hormone testing improves cure rates in patients undergoing minimally invasive parathyroidectomy.Surgery2005. 138 (4):587\u2013590."},{"issue":"9","key":"i0020-8868-97-2-99-Sackett1","series-title":"Arch Surg","first-page":"1055","article-title":"Worldwide trends in the surgical treatment of primary hyperparathyroidism in the era of minimally invasive parathyroidectomy.","volume":"137","author":"Sackett\n              WR","year":"2002","unstructured":"Sackett\n              WR\n            , BarracloughB, ReeveTS, and DelbridgeLW. Worldwide trends in the surgical treatment of primary hyperparathyroidism in the era of minimally invasive parathyroidectomy.Arch Surg2002. 137 (9):1055\u20131059."},{"issue":"2","key":"i0020-8868-97-2-99-Sharma1","series-title":"Ann Surg Oncol","first-page":"493","article-title":"Value of intraoperative parathyroid hormone monitoring.","volume":"15","author":"Sharma\n              J","year":"2008","unstructured":"Sharma\n              J\n            , MilasM, BerberE, MazzagliaP, SipersteinA, and WeberCJ. Value of intraoperative parathyroid hormone monitoring.Ann Surg Oncol2008. 15 (2):493\u2013498."},{"issue":"5","key":"i0020-8868-97-2-99-Goldstein1","series-title":"Ann Surg","first-page":"732","article-title":"Effect of minimally invasive radioguided parathyroidectomy on efficacy, length of stay, and costs in the management of primary hyperparathyroidism.","volume":"231","author":"Goldstein\n              RE","year":"2000","unstructured":"Goldstein\n              RE\n            , BlevinsL, DelbekeD, and MartinWH. Effect of minimally invasive radioguided parathyroidectomy on efficacy, length of stay, and costs in the management of primary hyperparathyroidism.Ann Surg2000. 231 (5):732\u2013742."},{"issue":"3","key":"i0020-8868-97-2-99-Denham1","series-title":"J Am Coll Surg","first-page":"293","article-title":"Cost-effectiveness of preoperative sestamibi scan for primary hyperparathyroidism is dependent solely upon the surgeon's choice of operative procedure.","volume":"186","author":"Denham\n              DW","year":"1998","unstructured":"Denham\n              DW\n             and NormanJ. Cost-effectiveness of preoperative sestamibi scan for primary hyperparathyroidism is dependent solely upon the surgeon's choice of operative procedure.J Am Coll Surg1998. 186 (3):293\u2013305."},{"issue":"5","key":"i0020-8868-97-2-99-Goldstein2","series-title":"Ann Surg","first-page":"722","article-title":"Sestamibi scanning and minimally invasive radioguided parathyroidectomy without intraoperative parathyroid hormone measurement.","volume":"237","author":"Goldstein\n              R","year":"2003","unstructured":"Goldstein\n              R\n            , BillheimerD, MartinWH, and RichardsK. Sestamibi scanning and minimally invasive radioguided parathyroidectomy without intraoperative parathyroid hormone measurement.Ann Surg2003. 237 (5):722\u2013731."},{"issue":"3","key":"i0020-8868-97-2-99-Rubello2","series-title":"Tumori","first-page":"S63","article-title":"99mTc-MIBI radio-guided surgery in primary hyperparathyroidism: a prospective study of 128 patients.","volume":"88","author":"Rubello\n              D","year":"2002","unstructured":"Rubello\n              D\n            , CasaraD, SaladiniG, et al. 99mTc-MIBI radio-guided surgery in primary hyperparathyroidism: a prospective study of 128 patients.Tumori2002. 88 (3):S63\u2013S65."},{"issue":"9","key":"i0020-8868-97-2-99-Casara1","series-title":"Eur J Nucl Med","first-page":"1351","article-title":"Clinical role of 99mTcO4\/MIBI scan, ultrasound and intraoperative gamma probe in the performance of unilateral and minimally invasive surgery in primary hyperparathyroidism.","volume":"28","author":"Casara\n              D","year":"2001","unstructured":"Casara\n              D\n            , RubelloD, PelizzoMR, and ShapiroB. Clinical role of 99mTcO4\/MIBI scan, ultrasound and intraoperative gamma probe in the performance of unilateral and minimally invasive surgery in primary hyperparathyroidism.Eur J Nucl Med2001. 28 (9):1351\u20131359."},{"issue":"5","key":"i0020-8868-97-2-99-Usmani1","series-title":"Med Princ Pract","first-page":"373","article-title":"Minimally invasive radionuclide-guided parathyroidectomy using 99mTc-sestamibi in patients with primary hyperparathyroidism: a single-institution experience.","volume":"18","author":"Usmani\n              S","year":"2009","unstructured":"Usmani\n              S\n            , KhanHA, Al MohannadiS, et al. Minimally invasive radionuclide-guided parathyroidectomy using 99mTc-sestamibi in patients with primary hyperparathyroidism: a single-institution experience.Med Princ Pract2009. 18 (5):373\u2013377."},{"issue":"5","key":"i0020-8868-97-2-99-Cassinello1","series-title":"Langenbecks Arch Surg","first-page":"869","article-title":"Intraoperative real-time 99mTc-sestamibi scintigraphy with miniature gamma camera allows minimally invasive parathyroidectomy without ioPTH determination in primary hyperparathyroidism.","volume":"394","author":"Cassinello\n              N","year":"2009","unstructured":"Cassinello\n              N\n            , OrtegaJ, and LiedoS. Intraoperative real-time 99mTc-sestamibi scintigraphy with miniature gamma camera allows minimally invasive parathyroidectomy without ioPTH determination in primary hyperparathyroidism.Langenbecks Arch Surg2009. 394 (5):869\u2013874."},{"issue":"2","key":"i0020-8868-97-2-99-Ortega1","series-title":"Eur J Nucl Med Mol Imaging","first-page":"165","article-title":"Potential role of a new hand-held gamma camera in performing minimally invasive parathyroidectomy.","volume":"34","author":"Ortega\n              J","year":"2007","unstructured":"Ortega\n              J\n            , Ferrer-RebolledaJ, CassinelloN, and LledoS. Potential role of a new hand-held gamma camera in performing minimally invasive parathyroidectomy.Eur J Nucl Med Mol Imaging2007. 34 (2):165\u2013169."},{"issue":"2","key":"i0020-8868-97-2-99-Kitagawa1","series-title":"Med Sci Monit","first-page":"CS59","article-title":"Radioguided parathyroidectomy for primary hyperparathyroidism using the solid-state, multi-crystal gamma camera.","volume":"9","author":"Kitagawa\n              W","year":"2003","unstructured":"Kitagawa\n              W\n            , ShimixuK, and AkasuH. Radioguided parathyroidectomy for primary hyperparathyroidism using the solid-state, multi-crystal gamma camera.Med Sci Monit2003. 9 (2):CS59\u2013CS62."},{"issue":"6","key":"i0020-8868-97-2-99-Fujii2","series-title":"Am Surg","first-page":"690","article-title":"Use of a handheld, semiconductor (cadmium zinc telluride)-based gamma camera in navigation surgery for primary hyperparathyroidism.","volume":"77","author":"Fujii\n              T","year":"2011","unstructured":"Fujii\n              T\n            , YamaguchiS, YajimaR, TsutsumiS, UchidaN, AsaoT, et al. Use of a handheld, semiconductor (cadmium zinc telluride)-based gamma camera in navigation surgery for primary hyperparathyroidism.Am Surg2011. 77 (6):690\u2013693."},{"issue":"6","key":"i0020-8868-97-2-99-Abe1","series-title":"Eur J Nucl Med Mol Imaging","first-page":"805","article-title":"Performance evaluation of a hand-held, semiconductor (CdZnTe)-based gamma camera.","volume":"30","author":"Abe\n              A","year":"2003","unstructured":"Abe\n              A\n            , TakahashiN, LeeJ, et al. Performance evaluation of a hand-held, semiconductor (CdZnTe)-based gamma camera.Eur J Nucl Med Mol Imaging2003. 30 (6):805\u2013811."},{"issue":"4","key":"i0020-8868-97-2-99-Otake1","series-title":"Kaku Igaku","first-page":"549","article-title":"Evaluation of efficiency of a semiconductor gamma camera.","volume":"39","author":"Otake\n              H","year":"2002","unstructured":"Otake\n              H\n            , HiguchiT, TakeuchiY, et al. Evaluation of efficiency of a semiconductor gamma camera.Kaku Igaku2002. 39 (4):549\u2013553."},{"issue":"6","key":"i0020-8868-97-2-99-Stratmann1","series-title":"Am J Surg","first-page":"578","article-title":"Comparison of quick parathyroid assay for uniglandular and multiglandular parathyroid disease.","volume":"184","author":"Stratmann\n              SL","year":"2002","unstructured":"Stratmann\n              SL\n            , KuhnJA, BellMS, PreskittJT, O'BrienJC, GableDR, et al. Comparison of quick parathyroid assay for uniglandular and multiglandular parathyroid disease.Am J Surg2002. 184 (6):578\u2013581."},{"issue":"1","key":"i0020-8868-97-2-99-Nichols1","series-title":"Nucl Med Commun","first-page":"43","article-title":"Sestamibi parathyroid scintigraphy in multigland disease.","volume":"33","author":"Nichols\n              KJ","year":"2012","unstructured":"Nichols\n              KJ\n            , TomasMB, TroncoGG, and PalestroCJ. Sestamibi parathyroid scintigraphy in multigland disease.Nucl Med Commun2012. 33 (1):43\u201350."},{"issue":"7","key":"i0020-8868-97-2-99-GmezRamrez1","series-title":"Langenbecks Arch Surg","first-page":"929","article-title":"Impact of thyroid nodular disease on 99mTc-sestamibi scintigraphy in patients with primary hyperparathyroidism.","volume":"395","author":"G\u00f3mez-Ram\u00edrez\n              J","year":"2010","unstructured":"G\u00f3mez-Ram\u00edrez\n              J\n            , Sancho-InsenserJJ, PereiraJA, JimenoJ, Munn\u00e9A, and Sitges-SerraA. Impact of thyroid nodular disease on 99mTc-sestamibi scintigraphy in patients with primary hyperparathyroidism.Langenbecks Arch Surg2010. 395 (7):929\u2013933."}],"container-title":["International Surgery"],"original-title":[],"link":[{"URL":"https:\/\/international-surgery.kglmeridian.com\/view\/journals\/insu\/97\/2\/article-p99.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/international-surgery\/article-pdf\/97\/2\/99\/2213410\/cc138_1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/international-surgery.kglmeridian.com\/downloadpdf\/journals\/insu\/97\/2\/article-p99.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/international-surgery.kglmeridian.com\/downloadpdf\/journals\/insu\/97\/2\/article-p99.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T19:02:37Z","timestamp":1751482957000},"score":1,"resource":{"primary":{"URL":"https:\/\/international-surgery.kglmeridian.com\/view\/journals\/insu\/97\/2\/article-p99.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":23,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.9738\/cc138.1","relation":{},"ISSN":["0020-8868","2520-2456"],"issn-type":[{"type":"print","value":"0020-8868"},{"type":"electronic","value":"2520-2456"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}