{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T19:40:06Z","timestamp":1751485206686,"version":"3.41.0"},"reference-count":13,"publisher":"International College of Surgeons","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n        <jats:p>Lynch syndrome is a rare and inherited defect disorder. People who have Lynch syndrome are strongly predisposed to develop colorectal cancer as well as several other types of cancer. The aim of this study was to explore features of ovarian cancers arising in families with Lynch syndrome. This study was a case report based on family history examining three patients with a new diagnosis of colorectal adenocarcinoma with ovarian cancer. Family members of carriers of the mutations were counseled, and those found to be at risk were offered mutation testing. The clinical criteria of the Amsterdam II guidelines for Lynch syndrome were used in this study. This is a maternal history of a 27-year-old woman sharing the destiny of her 48-year-old mother and 45-year-old aunt, both of which were suffering from Lynch syndrome associated with ovarian cancer. The maternal grandmother and maternal uncle of this young woman also suffered from colon cancer in their forties. The medical implications for the carrier relatives were considered as the maternal branch of the family.<\/jats:p>","DOI":"10.9738\/cc15.1","type":"journal-article","created":{"date-parts":[[2012,12,13]],"date-time":"2012-12-13T18:35:57Z","timestamp":1355423757000},"page":"286-290","source":"Crossref","is-referenced-by-count":2,"title":["Carcinomas Associated With Lynch Syndrome: A Family History"],"prefix":"10.9738","volume":"96","author":[{"given":"Gul","family":"Pinar","sequence":"first","affiliation":[{"name":"Department of Nursing and Healthcare Services, Baskent University Health Sciences Faculty, Baskent University Hospital, Cayyolu\/Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Ayhan","sequence":"additional","affiliation":[{"name":"Department of Gynecology Oncology, Baskent University Hospital, Cayyolu\/Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4721","reference":[{"year":"2003","series-title":"Textbook of Gastroenterology","key":"i0020-8868-96-4-286-Yamada1","unstructured":"Yamada, T, AlpersDH, KaplowitzN, LaineL, OwyangC, and PowellDW. eds.Textbook of Gastroenterology. Philadelphia, PAJ. B. Lippincott. 2003."},{"issue":"2","key":"i0020-8868-96-4-286-Backes1","series-title":"Clin Obstet Gynecol","first-page":"199","article-title":"Lynch syndrome.","volume":"54","author":"Backes, FJ","year":"2011","unstructured":"Backes, FJ and CohnDE. Lynch syndrome.Clin Obstet Gynecol2011. 54 (2):199\u2013214."},{"issue":"2","key":"i0020-8868-96-4-286-Lynch1","series-title":"Arch Intern Med","first-page":"206","article-title":"Hereditary factors in cancer. Study of two large midwestern kindreds.","volume":"117","author":"Lynch, HT","year":"1966","unstructured":"Lynch, HT, ShawMW, MagnusonCW, LarsenAL, and KrushAJ. Hereditary factors in cancer. Study of two large midwestern kindreds.Arch Intern Med1966. 117 (2):206\u2013212."},{"issue":"4","key":"i0020-8868-96-4-286-Grady1","series-title":"Gastroenterology","first-page":"1079","article-title":"Genomic and epigenetic instability in colorectal cancer pathogenesis.","volume":"135","author":"Grady, WM","year":"2008","unstructured":"Grady, WM and CarethersJM. Genomic and epigenetic instability in colorectal cancer pathogenesis.Gastroenterology2008. 135 (4):1079\u20131100."},{"issue":"2","key":"i0020-8868-96-4-286-Geary1","series-title":"Fam Cancer","first-page":"163","article-title":"Gene-related cancer spectrum in families with hereditary non-polyposis colorectal cancer (HNPCC).","volume":"7","author":"Geary, J","year":"2008","unstructured":"Geary, J, SasieniP, HoulstonR, IzattL, EelesR, PayneSJ, et al. Gene-related cancer spectrum in families with hereditary non-polyposis colorectal cancer (HNPCC).Fam Cancer2008. 7 (2):163\u2013172."},{"issue":"5","key":"i0020-8868-96-4-286-Green1","series-title":"J Natl Cancer Inst","first-page":"331","article-title":"Prediction of Lynch syndrome in consecutive patients with colorectal cancer.","volume":"101","author":"Green, RC","year":"2009","unstructured":"Green, RC, ParfreyPS, WoodsMO, and YounghusbandHB. Prediction of Lynch syndrome in consecutive patients with colorectal cancer.J Natl Cancer Inst2009. 101 (5):331\u2013140."},{"issue":"7","key":"i0020-8868-96-4-286-Jass1","series-title":"Eur J Cancer","first-page":"858","article-title":"Distinction between familial and sporadic forms of colorectal cancer showing DNA microsatellite instability.","volume":"38","author":"Jass, JR","year":"2002","unstructured":"Jass, JR, WalshMD, BarkerM, SimmsLA, YoungJ, and LeggettBA. Distinction between familial and sporadic forms of colorectal cancer showing DNA microsatellite instability.Eur J Cancer2002. 38 (7):858\u2013866."},{"issue":"18","key":"i0020-8868-96-4-286-Hampel1","series-title":"N Engl J Med","first-page":"1851","article-title":"Screening for the Lynch syndrome (hereditary nonpolyposis colorectal cancer).","volume":"352","author":"Hampel, H","year":"2005","unstructured":"Hampel, H, FrankelWL, MartinE, ArnoldM, KhandujaK, KueblerP, et al. Screening for the Lynch syndrome (hereditary nonpolyposis colorectal cancer).N Engl J Med2005. 352 (18):1851\u20131860."},{"issue":"1","key":"i0020-8868-96-4-286-AbdelRahman1","series-title":"Crit Rev Oncog","first-page":"1","article-title":"Lynch syndrome and related familial colorectal cancers.","volume":"14","author":"Abdel-Rahman, WM","year":"2008","unstructured":"Abdel-Rahman, WM and Peltom\u00e4kiP. Lynch syndrome and related familial colorectal cancers.Crit Rev Oncog2008. 14 (1):1\u201322."},{"issue":"2","key":"i0020-8868-96-4-286-Maradiegue1","series-title":"J Am Acad Nurse Pract","first-page":"76","article-title":"Scoping the family history: assessment of Lynch syndrome (hereditary nonpolyposis colorectal cancer) in primary care settings\u2014a primer for nurse practitioners.","volume":"20","author":"Maradiegue, A","year":"2008","unstructured":"Maradiegue, A, JaspersonK, EdwardsQT, LowstuterK, and WeitzelJ. Scoping the family history: assessment of Lynch syndrome (hereditary nonpolyposis colorectal cancer) in primary care settings\u2014a primer for nurse practitioners.J Am Acad Nurse Pract2008. 20 (2):76\u201384."},{"issue":"33","key":"i0020-8868-96-4-286-Lu1","series-title":"J Clin Oncol","first-page":"5158","article-title":"Prospective determination of prevalence of lynch syndrome in young women with endometrial cancer.","volume":"25","author":"Lu, KH","year":"2007","unstructured":"Lu, KH, SchorgeJO, RodabaughKJ, DanielsMS, SunCC, SolimanPT, et al. Prospective determination of prevalence of lynch syndrome in young women with endometrial cancer.J Clin Oncol2007. 25 (33):5158\u20135164."},{"issue":"1","key":"i0020-8868-96-4-286-Stoffel1","series-title":"Minerva Gastroenterol Dietol","first-page":"45","article-title":"Lynch syndrome\/hereditary non-polyposis colorectal cancer (HNPCC).","volume":"56","author":"Stoffel, EM","year":"2010","unstructured":"Stoffel, EM\n          . Lynch syndrome\/hereditary non-polyposis colorectal cancer (HNPCC).Minerva Gastroenterol Dietol2010. 56 (1):45\u201353."},{"issue":"2","key":"i0020-8868-96-4-286-Vasen1","series-title":"Fam Cancer","first-page":"109","article-title":"Recommendations to improve identification of hereditary and familial colorectal cancer in Europe.","volume":"9","author":"Vasen, HF","year":"2010","unstructured":"Vasen, HF, M\u00f6sleinG, AlonsoA, AretzS, BernsteinI, BertarioL, et al. Recommendations to improve identification of hereditary and familial colorectal cancer in Europe.Fam Cancer2010. 9 (2):109\u2013115."}],"container-title":["International Surgery"],"original-title":[],"link":[{"URL":"https:\/\/international-surgery.kglmeridian.com\/view\/journals\/insu\/96\/4\/article-p286.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/international-surgery\/article-pdf\/96\/4\/286\/2213700\/cc15_1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/international-surgery.kglmeridian.com\/downloadpdf\/journals\/insu\/96\/4\/article-p286.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/international-surgery.kglmeridian.com\/downloadpdf\/journals\/insu\/96\/4\/article-p286.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T19:06:21Z","timestamp":1751483181000},"score":1,"resource":{"primary":{"URL":"https:\/\/international-surgery.kglmeridian.com\/view\/journals\/insu\/96\/4\/article-p286.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":13,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.9738\/cc15.1","relation":{},"ISSN":["0020-8868","2520-2456"],"issn-type":[{"type":"print","value":"0020-8868"},{"type":"electronic","value":"2520-2456"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}