{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T12:44:20Z","timestamp":1785156260408,"version":"3.55.0"},"reference-count":24,"publisher":"International College of Surgeons","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:title>Abstract<\/jats:title>\n        <jats:p>We encountered a rare case of a well-differentiated endocrine carcinoma originating from the bile duct in association with a congenital choledochal cyst (CCC). The patient is a 28-year-old woman referred to our clinic for pruritus. Laboratory data showed mild elevation of serum hepatobiliary enzymes. Computed tomography and magnetic resonance imaging demonstrated pancreatobiliary maljunction and a Todani type IV-A CCC from the inferior bile duct to the bilateral intrahepatic bile ducts. A solid tumor was detected in the middle portion of the common bile duct. Pancreatoduodenectomy and total extrahepatic bile duct resection was performed. Based on pathologic and immunohistochemical examinations, a diagnosis of well-differentiated endocrine carcinoma was made according to the World Health Organization criteria. To our knowledge, this is the third report of a neuroendocrine tumor originating from the bile duct in association with a CCC.<\/jats:p>","DOI":"10.9738\/cc152.1","type":"journal-article","created":{"date-parts":[[2013,1,8]],"date-time":"2013-01-08T21:26:51Z","timestamp":1357680411000},"page":"315-320","source":"Crossref","is-referenced-by-count":14,"title":["Well-Differentiated Endocrine Carcinoma Originating From the Bile Duct in Association With a Congenital Choledochal Cyst"],"prefix":"10.9738","volume":"97","author":[{"given":"Kazuhiro","family":"Takahashi","sequence":"first","affiliation":[{"name":"Organ Transplantation Gastroenterological and Hepatobiliary Surgery, Division of Clinical Medicine, Faculty of Medicine, Graduate School of University of Tsukuba, Tsukuba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoko","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Organ Transplantation Gastroenterological and Hepatobiliary Surgery, Division of Clinical Medicine, Faculty of Medicine, Graduate School of University of Tsukuba, Tsukuba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Oshiro","sequence":"additional","affiliation":[{"name":"Organ Transplantation Gastroenterological and Hepatobiliary Surgery, Division of Clinical Medicine, Faculty of Medicine, Graduate School of University of Tsukuba, Tsukuba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Fukunaga","sequence":"additional","affiliation":[{"name":"Organ Transplantation Gastroenterological and Hepatobiliary Surgery, Division of Clinical Medicine, Faculty of Medicine, Graduate School of University of Tsukuba, Tsukuba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Oda","sequence":"additional","affiliation":[{"name":"Organ Transplantation Gastroenterological and Hepatobiliary Surgery, Division of Clinical Medicine, Faculty of Medicine, Graduate School of University of Tsukuba, Tsukuba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Ohkohchi","sequence":"additional","affiliation":[{"name":"Organ Transplantation Gastroenterological and Hepatobiliary Surgery, Division of Clinical Medicine, Faculty of Medicine, Graduate School of University of Tsukuba, Tsukuba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4721","reference":[{"issue":"3","key":"i0020-8868-97-4-315-Todani1","series-title":"Cancer","first-page":"1134","article-title":"Carcinoma arising in the wall of congenital bile cysts","volume":"44","author":"Todani\n              T ,","year":"1979","unstructured":"Todani\n              T , \n            \n              Tabuchi\n              K , \n            \n              Watanabe\n              Y , \n            \n              Kobayashi\n              T . \n          \n          Carcinoma arising in the wall of congenital bile cysts . 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Nippon Shokakigeka Gakkai Zasshi (Jpn Gastroenterol Surg)2005 ;38 (2 ):179 \u2013184 ."},{"issue":"4","key":"i0020-8868-97-4-315-Iwasa1","series-title":"Jpn J Clin Oncol","first-page":"313","article-title":"Cisplatin and etoposide as first-line chemotherapy for poorly differentiated neuroendocrine carcinoma of the hepatobiliary tract and pancreas","volume":"40","author":"Iwasa\n              S ,","year":"2010","unstructured":"Iwasa\n              S , \n            \n              Morizane\n              C , \n            \n              Okusaka\n              T , \n            \n              Ueno\n              H , \n            \n              Ikeda\n              M , \n            \n              Kondo\n              S , \n            et al . \n          Cisplatin and etoposide as first-line chemotherapy for poorly differentiated neuroendocrine carcinoma of the hepatobiliary tract and pancreas . Jpn J Clin Oncol2010 ;40 (4 ):313 \u2013318 ."},{"issue":"8","key":"i0020-8868-97-4-315-BarrnRodrguez1","series-title":"Am J Gastroenterol","first-page":"1073","article-title":"Carcinoid tumor of the common bile duct: evidence for its origin in metaplastic endocrine cells","volume":"86","author":"Barr\u00f3n-Rodr\u00edguez\n              LP ,","year":"1991","unstructured":"Barr\u00f3n-Rodr\u00edguez\n              LP , \n            \n              Manivel\n              JC , \n            \n              M\u00e9ndez-S\u00e1nchez\n              N , \n            \n              Jessurun\n              J . \n          \n          Carcinoid tumor of the common bile duct: evidence for its origin in metaplastic endocrine cells . Am J Gastroenterol1991 ;86 (8 ):1073 \u20131076 ."},{"issue":"3","key":"i0020-8868-97-4-315-Todani2","series-title":"J Hepatobiliary Pancreat Surg","first-page":"247","article-title":"Choledochal cyst, pancreatobiliary malunion, and cancer","volume":"1","author":"Todani\n              T ,","year":"1994","unstructured":"Todani\n              T , \n            \n              Watanabe\n              Y , \n            \n              Urushihara\n              N , \n            \n              Morotomi\n              Y , \n            \n              Maeba\n              T . \n          \n          Choledochal cyst, pancreatobiliary malunion, and cancer . J Hepatobiliary Pancreat Surg1994 ;1 (3 ):247 \u2013251 ."},{"issue":"8 suppl","key":"i0020-8868-97-4-315-Matsubara1","series-title":"Cancer","first-page":"1752","article-title":"K-ras point mutation in cancerous and noncancerous biliary epithelium in patients with pancreotico-biliary maljunction","volume":"77","author":"Matsubara\n              T ,","year":"1996","unstructured":"Matsubara\n              T , \n            \n              Sakurai\n              Y , \n            \n              Sasayama\n              Y , \n            \n              Hori\n              H , \n            \n              Ochiai\n              M , \n            \n              Funabiki\n              T , \n            et al . \n          K-ras point mutation in cancerous and noncancerous biliary epithelium in patients with pancreotico-biliary maljunction . Cancer1996 ;77 (8 suppl ):1752 \u20131757 ."},{"issue":"6","key":"i0020-8868-97-4-315-Tomono1","series-title":"Am J Gastroenterol","first-page":"1211","article-title":"Point mutations of the c-Ki-ras gene in carcinoma and atypical epithelium associated with congenital biliary dilation","volume":"91","author":"Tomono\n              H ,","year":"1996","unstructured":"Tomono\n              H , \n            \n              Nimura\n              Y , \n            \n              Aono\n              K , \n            \n              Nakashima\n              I , \n            \n              Iwamoto\n              T , \n            \n              Nakashima\n              N . \n          \n          Point mutations of the c-Ki-ras gene in carcinoma and atypical epithelium associated with congenital biliary dilation . Am J Gastroenterol1996 ;91 (6 ):1211 \u20131214 ."},{"issue":"3","key":"i0020-8868-97-4-315-Matsubara2","series-title":"J Hepatobiliary Pancreat Surg","first-page":"286","article-title":"p53 gene mutations and overexpression of p53 product in cancerous and noncancerous biliary epithelium in patients with pancreaticobiliary maljunction","volume":"6","author":"Matsubara\n              T ,","year":"1999","unstructured":"Matsubara\n              T , \n            \n              Funabiki\n              T , \n            \n              Jinno\n              O , \n            \n              Sakurai\n              Y , \n            \n              Hasegawa\n              S , \n            \n              Imazu\n              H , \n            et al . \n          p53 gene mutations and overexpression of p53 product in cancerous and noncancerous biliary epithelium in patients with pancreaticobiliary maljunction . 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J Pediatr Surg2009 ;44 (6 ):E23 \u201325 ."},{"issue":"12","key":"i0020-8868-97-4-315-Sreide1","series-title":"Br J Surg","first-page":"1538","article-title":"Bile duct cysts in adults","volume":"91","author":"S\u00f6reide\n              K ,","year":"2004","unstructured":"S\u00f6reide\n              K , \n            \n              K\u00f6rner\n              H , \n            \n              Havnen\n              J , \n            \n              S\u00f6reide\n              JA . \n          \n          Bile duct cysts in adults . Br J Surg2004 ;91 (12 ):1538 \u20131548 ."}],"container-title":["International Surgery"],"original-title":[],"link":[{"URL":"https:\/\/international-surgery.kglmeridian.com\/view\/journals\/insu\/97\/4\/article-p315.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/international-surgery\/article-pdf\/97\/4\/315\/2215945\/cc152_1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/international-surgery.kglmeridian.com\/downloadpdf\/journals\/insu\/97\/4\/article-p315.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/international-surgery.kglmeridian.com\/downloadpdf\/journals\/insu\/97\/4\/article-p315.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T19:04:26Z","timestamp":1751483066000},"score":1,"resource":{"primary":{"URL":"https:\/\/international-surgery.kglmeridian.com\/view\/journals\/insu\/97\/4\/article-p315.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":24,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.9738\/cc152.1","relation":{},"ISSN":["0020-8868","2520-2456"],"issn-type":[{"value":"0020-8868","type":"print"},{"value":"2520-2456","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}