{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T19:40:03Z","timestamp":1751485203840,"version":"3.41.0"},"reference-count":14,"publisher":"International College of Surgeons","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:title>Abstract<\/jats:title>\n        <jats:p>A 63-year-old man underwent a colectomy for sigmoid colon cancer in 1997. The upper lobe of his left lung and his left adrenal gland were resected because of metachronous metastases, 7 and 10 years after the initial surgery, respectively. Recurrence of metastases to the middle lobe of the right lung and left adrenal gland were sequentially detected in 2007, and a multimodal therapy, consisting of the combination of radiotherapy and chemotherapy, was conducted since 2007. The chemotherapy included drugs such as FOLFOX, FOLFIRI, bevacizumab, capecitabine, and cetuximab. In 2011, the complete response of all metastatic lesions could be achieved, and no recurrence was detected for more than 1 year. In spite of repeated recurrences, by the combination of surgical resection, chemotherapy, and radiotherapy, the complete response could be achieved 14 years after the initial surgical resection, which can be attributed to the development of new treatment modalities and new agents for colorectal cancer.<\/jats:p>","DOI":"10.9738\/cc172.1","type":"journal-article","created":{"date-parts":[[2013,2,25]],"date-time":"2013-02-25T19:39:56Z","timestamp":1361821196000},"page":"49-54","source":"Crossref","is-referenced-by-count":2,"title":["Colorectal Cancer With Multiple Metachronous Metastasis Achieving Complete Remission 14 Years After Surgical Resection: Report of a Case"],"prefix":"10.9738","volume":"98","author":[{"given":"Koji","family":"Murono","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazushige","family":"Kawai","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinsuke","family":"Kazama","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelson H.","family":"Tsuno","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Sunami","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joji","family":"Kitayama","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiaki","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4721","reference":[{"issue":"2","key":"i0020-8868-98-1-49-b01","series-title":"CA Cancer J Clin","first-page":"69","article-title":"Global cancer statistics","volume":"61","author":"Jemal\n              A ,","year":"2011","unstructured":"Jemal\n              A , \n            \n              Bray\n              F , \n            \n              Center\n              MM , \n            \n              Ferlay\n              J , \n            \n              Ward\n              E , \n            \n              Forman\n              D . \n          \n          Global cancer statistics . CA Cancer J Clin2011 ;61(2) :69 \u201390"},{"issue":"10","key":"i0020-8868-98-1-49-b02","series-title":"J Clin Oncol","first-page":"1559","article-title":"A prospective randomized trial of 5-fluorouracil versus 5-fluorouracil and high-dose leucovorin versus 5-fluorouracil and methotrexate in previously untreated patients with advanced colorectal carcinoma","volume":"5","author":"Petrelli\n              N ,","year":"1987","unstructured":"Petrelli\n              N , \n            \n              Herrera\n              L , \n            \n              Rustum\n              Y , \n            \n              Burke\n              P , \n            \n              Creaven\n              P , \n            \n              Stulc\n              J\n            \n            et al\n           . A prospective randomized trial of 5-fluorouracil versus 5-fluorouracil and high-dose leucovorin versus 5-fluorouracil and methotrexate in previously untreated patients with advanced colorectal carcinoma . 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Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer","volume":"360","author":"Van Cutsem\n              E ,","year":"2009","unstructured":"Van Cutsem\n              E , \n            \n              Kohne\n              CH , \n            \n              Hitre\n              E , \n            \n              Zaluski\n              J , \n          \n          Chang Chien CR, Makhson A et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer . N Engl J Med2009 ;360(14) :1408 \u20131417"},{"issue":"3","key":"i0020-8868-98-1-49-b05","series-title":"Clin Colorectal Cancer","first-page":"178","article-title":"Durable complete responses in metastatic colorectal cancer treated with chemotherapy alone","volume":"10","author":"Ferrarotto\n              R ,","year":"2011","unstructured":"Ferrarotto\n              R , \n            \n              Pathak\n              P , \n            \n              Maru\n              D , \n            \n              Agarwal\n              A , \n            \n              Overman\n              M , \n            \n              Hoff\n              PM\n            \n            et al\n           . Durable complete responses in metastatic colorectal cancer treated with chemotherapy alone . 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Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer . J Clin Oncol2000 ;18(16) :2938 \u20132947"},{"issue":"9206","key":"i0020-8868-98-1-49-b09","series-title":"Lancet","first-page":"1041","article-title":"Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial","volume":"355","author":"Douillard\n              JY ,","year":"2000","unstructured":"Douillard\n              JY , \n            \n              Cunningham\n              D , \n            \n              Roth\n              AD , \n            \n              Navarro\n              M , \n            \n              James\n              RD , \n            \n              Karasek\n              P\n            \n            et al\n           . Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial . Lancet2000 ;355(9206) :1041 \u20131047"},{"key":"i0020-8868-98-1-49-b10","series-title":"J Clin Oncol","first-page":"2282","article-title":"Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: results of a randomized phase III study","volume":"19","author":"Hoff\n              PM ,","year":"2001","unstructured":"Hoff\n              PM , \n            \n              Ansari\n              R , \n            \n              Batist\n              G , \n            \n              Cox\n              J , \n            \n              Kocha\n              W , \n            \n              Kuperminc\n              M\n            \n            et al\n           . Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: results of a randomized phase III study . J Clin Oncol2001 ;19 :2282 \u20132292"},{"issue":"8","key":"i0020-8868-98-1-49-b11","series-title":"N Engl J Med","first-page":"2335","article-title":"Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer","volume":"350","author":"Hurwitz\n              H ,","year":"2004","unstructured":"Hurwitz\n              H , \n            \n              Fehrenbacher\n              L , \n            \n              Novotny\n              W , \n            \n              Cartwright\n              T , \n            \n              Hainsworth\n              J , \n            \n              Heim\n              W\n            \n            et al\n           . Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer . 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