{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:50:51Z","timestamp":1761630651768,"version":"3.41.0"},"reference-count":7,"publisher":"International College of Surgeons","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013]]},"abstract":"Abstract<\/jats:title>\n Recurrence of primary biliary cirrhosis (PBC) after liver transplantation has been shown to negatively affect graft and patient survival. Recently, protective effects of cyclosporine A against PBC recurrence after liver transplantation have been reported. Participants were 4 patients who underwent living-donor liver transplantation (LDLT) for end-stage liver disease due to PBC. Tacrolimus was used for initial immunosuppression, and this was switched to cyclosporine A at least 3 months after liver transplantation. Targeted trough level of cyclosporine A was 20 times that of tacrolimus. We assessed liver and renal function, as well as antimitochondrial M2 antibody for recipients prior to LDLT, as well as before and after switching immunosuppressive agents. Patients were 1 man and 3 women, and they were ages 45 to 47 years at LDLT. Timing of switching from tacrolimus to cyclosporine A was 13, 3, 7, and 4 months respectively after liver transplantation, and all 4 patients have been on cyclosporine A without adverse effects at 20 to 46 months after transplantation. In 2 of 4 patients who had high titers of antimitochondrial M2 antibody before transplantation, antibody titer did not elevate after LDLT. In the other 2 patients without elevation of antimitochondrial M2 antibody, the titer did not turn positive. Switching from tacrolimus to cyclosporine A was possible without medical problems, and all patients exhibit no recurrence of PBC. Cyclosporine A may be useful for prevention of PBC recurrence after LDLT.<\/jats:p>","DOI":"10.9738\/cc188","type":"journal-article","created":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T14:58:28Z","timestamp":1369321108000},"page":"156-159","source":"Crossref","is-referenced-by-count":8,"title":["Switching From Tacrolimus to Cyclosporine A to Prevent Primary Biliary Cirrhosis Recurrence After Living-Donor Liver Transplantation"],"prefix":"10.9738","volume":"98","author":[{"given":"Hiroaki","family":"Shiba","sequence":"first","affiliation":[{"name":"Department of Surgery, Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeki","family":"Wakiyama","sequence":"additional","affiliation":[{"name":"Department of Surgery, Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuro","family":"Futagawa","sequence":"additional","affiliation":[{"name":"Department of Surgery, Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Gocho","sequence":"additional","affiliation":[{"name":"Department of Surgery, Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryusuke","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Surgery, Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenei","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Department of Surgery, Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Surgery, Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeyuki","family":"Misawa","sequence":"additional","affiliation":[{"name":"Department of Surgery, Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiko","family":"Yanaga","sequence":"additional","affiliation":[{"name":"Department of Surgery, Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4721","reference":[{"issue":"4","key":"i0020-8868-98-2-156-b01","series-title":"Am J Transplant","first-page":"852","article-title":"Cyclosporine A protects against primary biliary cirrhosis recurrence after liver transplantation","volume":"10","author":"Montano-Loza\n AJ,","year":"2010","unstructured":"Montano-Loza\n AJ, \n \n Wasilenko\n S, \n \n Bintner\n J, \n \n Mason\n AL. \n \n Cyclosporine A protects against primary biliary cirrhosis recurrence after liver transplantation. Am J Transplant2010;10(4):852\u2013858"},{"issue":"1","key":"i0020-8868-98-2-156-b02","series-title":"Hepatology","first-page":"22","article-title":"Transplantation for primary biliary cirrhosis: retrospective analysis of 400 patients in a single center","volume":"33","author":"Liermann Garcia\n RF,","year":"2001","unstructured":"Liermann Garcia\n RF, \n \n Evangelista Garcia\n C, \n \n McMaster\n P, \n \n Neuberger\n J. \n \n Transplantation for primary biliary cirrhosis: retrospective analysis of 400 patients in a single center. Hepatology2001;33(1):22\u201327"},{"issue":"1","key":"i0020-8868-98-2-156-b03","series-title":"N Engl J Med","first-page":"1","article-title":"Recurrence of primary biliary cirrhosis after liver transplantation","volume":"306","author":"Neuberger\n J,","year":"1982","unstructured":"Neuberger\n J, \n \n Portmann\n B, \n \n Macdougall\n BR, \n \n Calne\n RY, \n \n Williams\n R. \n \n Recurrence of primary biliary cirrhosis after liver transplantation. N Engl J Med1982;306(1):1\u20134"},{"issue":"9","key":"i0020-8868-98-2-156-b04","series-title":"Liver Transpl","first-page":"1236","article-title":"Long-term survival and impact of ursodeoxycholic acid treatment for recurrent primary biliary cirrhosis after liver transplantation","volume":"13","author":"Charatcharoenwitthaya\n P,","year":"2007","unstructured":"Charatcharoenwitthaya\n P, \n \n Pimentel\n S, \n \n Talwalkar\n JA, \n \n Enders\n FT, \n \n Lindor\n KD, \n \n Krom\n RA\n \n et al\n . Long-term survival and impact of ursodeoxycholic acid treatment for recurrent primary biliary cirrhosis after liver transplantation. Liver Transpl2007;13(9):1236\u20131245"},{"issue":"10","key":"i0020-8868-98-2-156-b05","series-title":"Liver Transpl","first-page":"1252","article-title":"Recurrent primary biliary cirrhosis: peritransplant factors and ursodeoxycholic acid treatment post-liver transplant","volume":"11","author":"Guy\n JE,","year":"2005","unstructured":"Guy\n JE, \n \n Qian\n P, \n \n Lowell\n JA, \n \n Peters\n MG. \n \n Recurrent primary biliary cirrhosis: peritransplant factors and ursodeoxycholic acid treatment post-liver transplant. Liver Transpl2005;11(10):1252\u20131257"},{"issue":"7","key":"i0020-8868-98-2-156-b06","series-title":"Liver Transpl","first-page":"733","article-title":"The effect of immunosuppressive regimens on the recurrence of primary biliary cirrhosis after liver transplantation","volume":"9","author":"Levitsky\n J,","year":"2003","unstructured":"Levitsky\n J, \n \n Hart\n J, \n \n Cohen\n SM, \n \n Te\n HS. \n \n The effect of immunosuppressive regimens on the recurrence of primary biliary cirrhosis after liver transplantation. Liver Transpl2003;9(7):733\u2013736"},{"issue":"7","key":"i0020-8868-98-2-156-b07","series-title":"Am J Transplant","first-page":"1578","article-title":"Cyclosporin versus tacrolimus as primary immunosuppressant after liver transplantation: a meta-analysis","volume":"6","author":"McAlister\n VC,","year":"2006","unstructured":"McAlister\n VC, \n \n Haddad\n E, \n \n Renouf\n E, \n \n Malthaner\n RA, \n \n Kjaer\n MS, \n \n Gluud\n LL. \n \n Cyclosporin versus tacrolimus as primary immunosuppressant after liver transplantation: a meta-analysis. Am J Transplant2006;6(7):1578\u20131585"}],"container-title":["International Surgery"],"original-title":[],"link":[{"URL":"https:\/\/international-surgery.kglmeridian.com\/view\/journals\/insu\/98\/2\/article-p156.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/international-surgery\/article-pdf\/98\/2\/156\/2214116\/cc188.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/international-surgery.kglmeridian.com\/downloadpdf\/journals\/insu\/98\/2\/article-p156.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/international-surgery.kglmeridian.com\/downloadpdf\/journals\/insu\/98\/2\/article-p156.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T19:06:53Z","timestamp":1751483213000},"score":1,"resource":{"primary":{"URL":"https:\/\/international-surgery.kglmeridian.com\/view\/journals\/insu\/98\/2\/article-p156.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":7,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.9738\/cc188","relation":{},"ISSN":["0020-8868","2520-2456"],"issn-type":[{"type":"print","value":"0020-8868"},{"type":"electronic","value":"2520-2456"}],"subject":[],"published":{"date-parts":[[2013]]}}}