{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T19:00:36Z","timestamp":1761418836883,"version":"3.41.0"},"reference-count":22,"publisher":"International College of Surgeons","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n        <jats:p>We present a successfully treated case of mixed ductal-endocrine carcinoma of the pancreas complicated by right renal cell carcinoma. The patient had no symptoms, and laboratory data were close to the normal range. Enhanced computed tomography demonstrated a marked enhanced tumor, which appeared to be an endocrine tumor, at the pancreas uncus. We performed pyrolus-preserving pancreaticoduodenectomy, regional lymph node resection, and right nephrectomy. Histologically and immunohistochemically, the pancreas tumor had both a ductal (exocrine) and an endocrine component. The renal tumor was a typical clear cell carcinoma. A diagnosis of synchronous double cancer was made. As demonstrated in previously published reports, this type of mixed tumor has malignant potential for invasive ductal carcinoma. We propose that mixed ductal-endocrine carcinoma of the pancreas should be treated by surgical resection with a sufficient surgical margin and regional lymph node resection to improve the patient's prognosis.<\/jats:p>","DOI":"10.9738\/cc8.1","type":"journal-article","created":{"date-parts":[[2012,12,13]],"date-time":"2012-12-13T18:35:24Z","timestamp":1355423724000},"page":"153-158","source":"Crossref","is-referenced-by-count":13,"title":["Mixed Ductal-Endocrine Carcinoma of the Pancreas Occurring as a Double Cancer: Report of a Case"],"prefix":"10.9738","volume":"96","author":[{"given":"Kenichiro","family":"Araki","sequence":"first","affiliation":[{"name":"Department of General Surgical Science (Surgery I), Gunma University Graduate School of Medicine, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"Shimura","sequence":"additional","affiliation":[{"name":"Department of General Surgical Science (Surgery I), Gunma University Graduate School of Medicine, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of General Surgical Science (Surgery I), Gunma University Graduate School of Medicine, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kana","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of General Surgical Science (Surgery I), Gunma University Graduate School of Medicine, Gunma, Japan"},{"name":"Department of Tumor Pathology, Gunma University Graduate School of Medicine, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of General Surgical Science (Surgery I), Gunma University Graduate School of Medicine, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of General Surgical Science (Surgery I), Gunma University Graduate School of Medicine, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of General Surgical Science (Surgery I), Gunma University Graduate School of Medicine, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Kashiwabara","sequence":"additional","affiliation":[{"name":"Department of Tumor Pathology, Gunma University Graduate School of Medicine, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Tumor Pathology, Gunma University Graduate School of Medicine, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Kuwano","sequence":"additional","affiliation":[{"name":"Department of General Surgical Science (Surgery I), Gunma University Graduate School of Medicine, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4721","reference":[{"key":"i0020-8868-96-2-153-Heitz1","series-title":"World Health Organization Classification of Tumours, Pathology and Genetics: Tumours of Endocrine Organs","author":"Heitz, P","year":"2004","unstructured":"Heitz, P, KomminothP, and PerrenA. World Health Organization Classification of Tumours, Pathology and Genetics: Tumours of Endocrine Organs. LyonIARC Press. 2004."},{"issue":"2","key":"i0020-8868-96-2-153-Kloppel1","series-title":"Semin Diagn Pathol","first-page":"104","article-title":"Mixed exocrine-endocrine tumors of the pancreas.","volume":"17","author":"Kloppel, G","year":"2000","unstructured":"Kloppel, G\n          . Mixed exocrine-endocrine tumors of the pancreas.Semin Diagn Pathol2000. 17 (2):104\u2013108."},{"issue":"6","key":"i0020-8868-96-2-153-Slack1","series-title":"Development","first-page":"1569","article-title":"Developmental biology of the pancreas.","volume":"121","author":"Slack, JM","year":"1995","unstructured":"Slack, JM\n          . Developmental biology of the pancreas.Development1995. 121 (6):1569\u20131580."},{"issue":"1","key":"i0020-8868-96-2-153-Cubilla1","series-title":"CA Cancer J Clin","first-page":"2","article-title":"Cancer of the exocrine pancreas: the pathologic aspects.","volume":"35","author":"Cubilla, AL","year":"1985","unstructured":"Cubilla, AL and FitzgeraldPJ. Cancer of the exocrine pancreas: the pathologic aspects.CA Cancer J Clin1985. 35 (1):2\u201318."},{"issue":"1","key":"i0020-8868-96-2-153-Tanaka1","series-title":"Suizo","first-page":"e1","article-title":"Pancreatic cancer registry report 2007 (in Japanese).","volume":"22","author":"Tanaka, M","year":"2007","unstructured":"Tanaka, M\n          . Pancreatic cancer registry report 2007 (in Japanese).Suizo2007. 22 (1):e1\u2013e427."},{"issue":"6","key":"i0020-8868-96-2-153-Eusebi1","series-title":"Histopathology","first-page":"599","article-title":"Endocrine-paracrine cells in pancreatic exocrine carcinomas.","volume":"5","author":"Eusebi, V","year":"1981","unstructured":"Eusebi, V, CapellaC, BondiA, SessaF, VezzadiniP, and ManciniAM. Endocrine-paracrine cells in pancreatic exocrine carcinomas.Histopathology1981. 5 (6):599\u2013613."},{"issue":"5","key":"i0020-8868-96-2-153-Reid1","series-title":"Cancer","first-page":"908","article-title":"Ductuloinsular tumors of the pancreas: a light, electron microscopic and immunohistochemical study.","volume":"49","author":"Reid, JD","year":"1982","unstructured":"Reid, JD, YuhSL, PetrelliM, and JaffeR. Ductuloinsular tumors of the pancreas: a light, electron microscopic and immunohistochemical study.Cancer1982. 49 (5):908\u2013915."},{"issue":"12","key":"i0020-8868-96-2-153-Ordonez1","series-title":"Hum Pathol","first-page":"1458","article-title":"Mucinous islet cell (amphicrine) carcinoma of the pancreas associated with watery diarrhea and hypokalemia syndrome.","volume":"19","author":"Ordonez, NG","year":"1988","unstructured":"Ordonez, NG, BalsaverAM, and MackayB. Mucinous islet cell (amphicrine) carcinoma of the pancreas associated with watery diarrhea and hypokalemia syndrome.Hum Pathol1988. 19 (12):1458\u20131461."},{"issue":"5","key":"i0020-8868-96-2-153-Nonomura1","series-title":"Acta Pathol Jpn","first-page":"328","article-title":"Duct-islet cell tumor of the pancreas: a case report with immunohistochemical and electron microscopic findings.","volume":"39","author":"Nonomura, A","year":"1989","unstructured":"Nonomura, A, MizukamiY, MatsubaraF, KonoN, and NakanumaY. Duct-islet cell tumor of the pancreas: a case report with immunohistochemical and electron microscopic findings.Acta Pathol Jpn1989. 39 (5):328\u2013335."},{"issue":"8","key":"i0020-8868-96-2-153-Kashiwabara1","series-title":"Acta Pathol Jpn","first-page":"636","article-title":"A case of malignant duct-islet cell tumor of the pancreas immunohistochemical and cytofluorometric study.","volume":"41","author":"Kashiwabara, K","year":"1991","unstructured":"Kashiwabara, K, NakajimaT, ShinkaiH, FukudaT, OonoY, KurabayashiY, et al. 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A case of mixed duct-islet cell tumor of the pancreas (in Japanese with English abstract).Nippon Shokakibyo Gakkai Zasshi (Jpn J Gastroenterol)2007. 104 (6):829\u2013836."}],"container-title":["International Surgery"],"original-title":[],"link":[{"URL":"https:\/\/international-surgery.kglmeridian.com\/view\/journals\/insu\/96\/2\/article-p153.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/international-surgery\/article-pdf\/96\/2\/153\/2215538\/cc8_1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/international-surgery.kglmeridian.com\/downloadpdf\/journals\/insu\/96\/2\/article-p153.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/international-surgery.kglmeridian.com\/downloadpdf\/journals\/insu\/96\/2\/article-p153.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T19:06:44Z","timestamp":1751483204000},"score":1,"resource":{"primary":{"URL":"https:\/\/international-surgery.kglmeridian.com\/view\/journals\/insu\/96\/2\/article-p153.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":22,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.9738\/cc8.1","relation":{},"ISSN":["0020-8868","2520-2456"],"issn-type":[{"type":"print","value":"0020-8868"},{"type":"electronic","value":"2520-2456"}],"subject":[],"published":{"date-parts":[[2011,4]]}}}