{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T04:19:44Z","timestamp":1787977184097,"version":"build-2784847793"},"reference-count":33,"publisher":"International College of Surgeons","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n        <jats:p>At the time of diagnosis, 20% to 25% of patients with colorectal cancer already have liver metastases, the presence of which is a most important prognostic factor. A 64-year-old man was admitted to our hospital for investigation of anemia and multiple liver tumors. Examinations revealed ascending colon carcinoma with more than 40 liver metastases and 2 lung metastases. We performed right hemicolectomy with lymph node dissection, which was followed by 5-fluorouracil\/leucovorin, oxaliplatin, plus bevacizumab (FOLFOX-BV). After 4 courses of chemotherapy, the lung metastases were in complete remission and the liver metastases had shrunk. We suggested the option of radical liver resection, but the patient declined initially as he had not suffered any severe side effects of FOLFOX-BV. After 23 courses of the chemotherapy, he agreed to undergo hepatectomy. We performed extended right lobectomy with partial left and caudal lobe resection. All of the macroscopic metastatic lesions were resected. Histopathologically, viable cancer cells were recognized in 7 of the 43 liver metastatic lesions. Postoperatively, FOLFOX-BV was restarted and continued for 10\u00a0months. At the time of writing, 15\u00a0months after the hepatectomy, the patient was well without evidence of recurrence of the cancer.<\/jats:p>","DOI":"10.9738\/cc88.1","type":"journal-article","created":{"date-parts":[[2012,10,25]],"date-time":"2012-10-25T15:57:41Z","timestamp":1351180661000},"page":"6-13","source":"Crossref","is-referenced-by-count":3,"title":["Successful Combination Therapy of Radical Liver Resection With 5-Fluorouracil\/leucovorin, Oxaliplatin, Plus Bevacizumab for Ascending Colon Cancer With Pulmonary and 43 Liver Metastases: Report of a Case"],"prefix":"10.9738","volume":"97","author":[{"given":"Takanori","family":"Ochiai","sequence":"first","affiliation":[{"name":"Department of Hepato-Biliary-Pancratic Surgery, Tokyo Medical and Dental University, Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan"},{"name":"Department of Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiki","family":"Masuda","sequence":"additional","affiliation":[{"name":"Department of Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Yagi","sequence":"additional","affiliation":[{"name":"Department of Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reo","family":"Kasai","sequence":"additional","affiliation":[{"name":"Department of Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaki","family":"Furuyama","sequence":"additional","affiliation":[{"name":"Department of Hepato-Biliary-Pancratic Surgery, Tokyo Medical and Dental University, Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan"},{"name":"Department of Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanako","family":"Tsukamoto","sequence":"additional","affiliation":[{"name":"Department of Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromitsu","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Hepato-Biliary-Pancratic Surgery, Tokyo Medical and Dental University, Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan"},{"name":"Department of Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimihiro","family":"Igari","sequence":"additional","affiliation":[{"name":"Department of Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arihiro","family":"Aihara","sequence":"additional","affiliation":[{"name":"Department of Hepato-Biliary-Pancratic Surgery, Tokyo Medical and Dental University, Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan"},{"name":"Department of Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Kumagai","sequence":"additional","affiliation":[{"name":"Department of Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michio","family":"Iida","sequence":"additional","affiliation":[{"name":"Department of Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Odajima","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ohta Nishinouchi General Hospital, Koriyama, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Hepato-Biliary-Pancratic Surgery, Tokyo Medical and Dental University, Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Arii","sequence":"additional","affiliation":[{"name":"Department of Hepato-Biliary-Pancratic Surgery, Tokyo Medical and Dental University, Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4721","reference":[{"issue":"28","key":"i0020-8868-97-1-6-Poston1","series-title":"J Clin Oncol","first-page":"7125","article-title":"OncoSurge: a strategy for improving resectability with curative intent in metastatic colorectal cancer.","volume":"23","author":"Poston, GJ","year":"2005","unstructured":"Poston, GJ, AdamR, AlbertsS, CurleyS, FiguerasJ, HallerD, et al. OncoSurge: a strategy for improving resectability with curative intent in metastatic colorectal cancer.J Clin Oncol2005. 23 (28):7125\u20137134."},{"issue":"4","key":"i0020-8868-97-1-6-Galizia1","series-title":"Arch Surg","first-page":"352","article-title":"First-line chemotherapy vs bowel tumor resection plus chemotherapy for patients with unresectable synchronous colorectal hepatic metastases.","volume":"143","author":"Galizia, G","year":"2008","unstructured":"Galizia, G, LietoE, OrdituraM, CastellanoP, ImperatoreV, PintoM, et al. First-line chemotherapy vs bowel tumor resection plus chemotherapy for patients with unresectable synchronous colorectal hepatic metastases.Arch Surg2008. 143 (4):352\u2013358."},{"issue":"8910","key":"i0020-8868-97-1-6-Stangl1","series-title":"Lancet","first-page":"1405","article-title":"Factors influencing the natural history of colorectal liver metastases.","volume":"343","author":"Stangl, R","year":"1994","unstructured":"Stangl, R, Altendorf-HofmannA, CharnleyRM, and ScheeleJ. Factors influencing the natural history of colorectal liver metastases.Lancet1994. 343 (8910):1405\u20131410."},{"issue":"11","key":"i0020-8868-97-1-6-Scheele1","series-title":"Br J Surg","first-page":"1241","article-title":"Hepatic metastases from colorectal carcinoma: impact of surgical resection on the natural history.","volume":"77","author":"Scheele, J","year":"1990","unstructured":"Scheele, J, StanglR, and Altendorf-HofmannA. 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Surgical decision making for large bowel cancer metastatic to the liver.Radiology1990(3 Pt 1). 174:621\u2013626."},{"issue":"3","key":"i0020-8868-97-1-6-Registry1","series-title":"Surgery","first-page":"278","article-title":"Resection of the liver for colorectal carcinoma metastases: a multi-institutional study of indications for resection.","volume":"103","year":"1988","unstructured":"Registry of Hepatic Metastases\n          \n          Resection of the liver for colorectal carcinoma metastases: a multi-institutional study of indications for resection.\n          Surgery\n          1988. 103 (3):278\u2013288."},{"issue":"1","key":"i0020-8868-97-1-6-Goldberg1","series-title":"J Clin Oncol","first-page":"23","article-title":"A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer.","volume":"22","author":"Goldberg, RM","year":"2004","unstructured":"Goldberg, RM, SargentDJ, MortonRF, FuchsCS, RamanathanRK, WilliamsonSK, et al. 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Surgical resection of primary tumors in patients who present with stage IV colorectal cancer: an analysis of surveillance, epidemiology, and end results data, 1988 to 2000.Ann Surg Oncol2005. 12 (8):637\u2013645."},{"issue":"8 Pt 2","key":"i0020-8868-97-1-6-Lee1","series-title":"J Gastroenterol Hepatol","first-page":"e367","article-title":"Treatment outcomes of hepatic and pulmonary metastases from colorectal carcinoma.","volume":"23","author":"Lee, WS","year":"2008","unstructured":"Lee, WS, YunHR, YunSH, ChunHK, LeeWY, KimSJ, et al. Treatment outcomes of hepatic and pulmonary metastases from colorectal carcinoma.J Gastroenterol Hepatol2008. 23 (8 Pt 2):e367\u2013e372."},{"issue":"1","key":"i0020-8868-97-1-6-Arru1","series-title":"World J Surg","first-page":"93","article-title":"Analysis of prognostic factors influencing long-term survival after hepatic resection for metastatic colorectal cancer.","volume":"32","author":"Arru, M","year":"2008","unstructured":"Arru, M, AldrighettiL, CastoldiR, Di PaloS, OrsenigoE, StellaM, et al. Analysis of prognostic factors influencing long-term survival after hepatic resection for metastatic colorectal cancer.World J Surg2008. 32 (1):93\u2013103."},{"issue":"78","key":"i0020-8868-97-1-6-Taniai1","series-title":"Hepatogastroenterology","first-page":"1805","article-title":"Surgical treatment for better prognosis of patients with liver metastases from colorectal cancer.","volume":"54","author":"Taniai, N","year":"2007","unstructured":"Taniai, N, AkimaruK, YoshidaH, and TajiriT. 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Bevacizumab improves pathologic response and protects against hepatic injury in patients treated with oxaliplatin-based chemotherapy for colorectal liver metastases.Cancer2007. 110 (12):2761\u20132767."},{"issue":"3","key":"i0020-8868-97-1-6-Zorzi1","series-title":"Br J Surg","first-page":"274","article-title":"Chemotherapy-associated hepatotoxicity and surgery for colorectal liver metastases.","volume":"94","author":"Zorzi, D","year":"2007","unstructured":"Zorzi, D, LaurentA, PawlikTM, LauwersGY, VautheyJN, and AbdallaEK. Chemotherapy-associated hepatotoxicity and surgery for colorectal liver metastases.Br J Surg2007. 94 (3):274\u2013286."},{"issue":"8","key":"i0020-8868-97-1-6-Kooby1","series-title":"J Gastrointest Surg","first-page":"1034","article-title":"Impact of steatosis on perioperative outcome following hepatic resection.","volume":"7","author":"Kooby, DA","year":"2003","unstructured":"Kooby, DA, FongY, SuriawinataA, GonenM, AllenPJ, KlimstraDS, et al. Impact of steatosis on perioperative outcome following hepatic resection.J Gastrointest Surg2003. 7 (8):1034\u20131044."},{"issue":"3","key":"i0020-8868-97-1-6-RubbiaBrandt1","series-title":"Ann Oncol","first-page":"460","article-title":"Severe hepatic sinusoidal obstruction associated with oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer.","volume":"15","author":"Rubbia-Brandt, L","year":"2004","unstructured":"Rubbia-Brandt, L, AudardV, SartorettiP, RothAD, BrezaultC, Le CharpentierM, et al. Severe hepatic sinusoidal obstruction associated with oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer.Ann Oncol2004. 15 (3):460\u2013466."},{"issue":"21","key":"i0020-8868-97-1-6-Hochster1","series-title":"J Clin Oncol","first-page":"3523","article-title":"Safety and efficacy of oxaliplatin and fluoropyrimidine regimens with or without bevacizumab as first-line treatment of metastatic colorectal cancer: results of the TREE study.","volume":"26","author":"Hochster, HS","year":"2008","unstructured":"Hochster, HS, HartLL, RamanathanRK, ChildsBH, HainsworthJD, CohnAL, et al. Safety and efficacy of oxaliplatin and fluoropyrimidine regimens with or without bevacizumab as first-line treatment of metastatic colorectal cancer: results of the TREE study.J Clin Oncol2008. 26 (21):3523\u20133529."},{"issue":"11","key":"i0020-8868-97-1-6-Kishi1","series-title":"Ann Surg Oncol","first-page":"2870","article-title":"Extended preoperative chemotherapy does not improve pathologic response and increases postoperative liver insufficiency after hepatic resection for colorectal liver metastases.","volume":"17","author":"Kishi, Y","year":"2010","unstructured":"Kishi, Y, ZorziD, ContrerasCM, MaruDM, KopetzS, RiberoD, et al. Extended preoperative chemotherapy does not improve pathologic response and increases postoperative liver insufficiency after hepatic resection for colorectal liver metastases.Ann Surg Oncol2010. 17 (11):2870\u20132876."}],"container-title":["International Surgery"],"original-title":[],"link":[{"URL":"https:\/\/international-surgery.kglmeridian.com\/view\/journals\/insu\/97\/1\/article-p6.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/international-surgery\/article-pdf\/97\/1\/6\/2213470\/cc88_1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/international-surgery.kglmeridian.com\/downloadpdf\/journals\/insu\/97\/1\/article-p6.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/international-surgery.kglmeridian.com\/downloadpdf\/journals\/insu\/97\/1\/article-p6.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T19:02:49Z","timestamp":1751482969000},"score":1,"resource":{"primary":{"URL":"https:\/\/international-surgery.kglmeridian.com\/view\/journals\/insu\/97\/1\/article-p6.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":33,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.9738\/cc88.1","relation":{},"ISSN":["2520-2456","0020-8868"],"issn-type":[{"value":"2520-2456","type":"electronic"},{"value":"0020-8868","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}