{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T23:59:19Z","timestamp":1768435159495,"version":"3.49.0"},"reference-count":28,"publisher":"International College of Surgeons","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n        <jats:p>Medications, including topical 0.2% glyceryl trinitrate (GTN), can reduce anal spasm and pain after excisional hemorrhoidectomy. GTN after stapled hemorrhoidopexy was compared with routine postoperative management. Patients with symptomatic grade 3\/4 hemorrhoids were recruited. After stapled hemorrhoidopexy, residual perianal skin tags were excised as appropriate. Those requiring double purse-string mucosectomy were excluded. Postoperative pain, pain duration, and complications were assessed. One hundred ten patients (74 men; mean age 50.6\u00a0years) were enrolled in the control group and 100 patients (57 men; mean age 49.8\u00a0years) in the GTN group. Maximum pain was higher in the GTN group (<jats:italic>P<\/jats:italic> \u200a=\u200a 0.015). There were no differences between the two groups in residual perianal skin tags requiring excision, postoperative complications, recurrence rates, follow-up period, average pain, duration of pain, or satisfaction scores. Sixteen GTN patients were noncompliant due to side effects. None had persistent perianal skin tags. GTN did not reduce postoperative pain after stapled hemorrhoidectomy.<\/jats:p>","DOI":"10.9738\/cc92.1","type":"journal-article","created":{"date-parts":[[2012,10,25]],"date-time":"2012-10-25T15:57:41Z","timestamp":1351180661000},"page":"112-119","source":"Crossref","is-referenced-by-count":8,"title":["Glyceryl Trinitrate Ointment Did Not Reduce Pain After Stapled Hemorrhoidectomy: A Randomized Controlled Trial"],"prefix":"10.9738","volume":"97","author":[{"given":"Trent","family":"Cross","sequence":"first","affiliation":[{"name":"Department of Surgery School of Medicine, Townsville and the Australian Institute of Tropical Medicine, within the North Queensland Centre for Cancer Research, James Cook University, Townsville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynne","family":"Bartlett","sequence":"additional","affiliation":[{"name":"School of Public Health, Tropical Medicine & Rehabilitation Science, within the North Queensland Centre for Cancer Research, James Cook University, Townsville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chrispen","family":"Mushaya","sequence":"additional","affiliation":[{"name":"Department of Surgery School of Medicine, Townsville and the Australian Institute of Tropical Medicine, within the North Queensland Centre for Cancer Research, James Cook University, Townsville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Ashour","sequence":"additional","affiliation":[{"name":"Department of Surgery School of Medicine, Townsville and the Australian Institute of Tropical Medicine, within the North Queensland Centre for Cancer Research, James Cook University, Townsville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yik-Hong","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Surgery School of Medicine, Townsville and the Australian Institute of Tropical Medicine, within the North Queensland Centre for Cancer Research, James Cook University, Townsville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4721","reference":[{"issue":"26","key":"i0020-8868-97-2-112-Schubert1","series-title":"World J Gastroenterol","first-page":"3201","article-title":"What every gastroenterologist needs to know about common anorectal disorders.","volume":"15","author":"Schubert\n              MC","year":"2009","unstructured":"Schubert\n              MC\n            , SridharS, SchadeRR, and WexnerSD. What every gastroenterologist needs to know about common anorectal disorders.World J Gastroenterol2009. 15 (26):3201\u20133209."},{"issue":"1","key":"i0020-8868-97-2-112-Pescatori1","series-title":"Tech Coloproctol","first-page":"96","article-title":"Transanal stapled excision of rectal mucosal prolapse.","author":"Pescatori\n              M","year":"1997","unstructured":"Pescatori\n              M\n            , FavettaU, DedolaS, and OrsiniS. Transanal stapled excision of rectal mucosal prolapse.Tech Coloproctol1997. (1):96\u201398. ."},{"issue":"8","key":"i0020-8868-97-2-112-Burch1","series-title":"Health Technol Assess","first-page":"iii","article-title":"Stapled haemorrhoidectomy (haemorrhoidopexy) for the treatment of haemorrhoids: a systematic review and economic evaluation.","volume":"12","author":"Burch\n              J","year":"2008","unstructured":"Burch\n              J\n            , EpsteinD, Baba-AkbariA, WeatherlyH, FoxD, GolderS, et al. Stapled haemorrhoidectomy (haemorrhoidopexy) for the treatment of haemorrhoids: a systematic review and economic evaluation.Health Technol Assess2008. 12 (8):iii\u2013iv, ix\u2013x, 1\u2013193."},{"issue":"11","key":"i0020-8868-97-2-112-Senagore1","series-title":"Dis Colon Rectum","first-page":"1824","article-title":"A prospective, randomized, controlled multicenter trial comparing stapled hemorrhoidopexy and Ferguson hemorrhoidectomy: perioperative and one-year results.","volume":"47","author":"Senagore\n              AJ","year":"2004","unstructured":"Senagore\n              AJ\n            , SingerM, AbcarianH, FleshmanJ, CormanM, WexnerS, et al. A prospective, randomized, controlled multicenter trial comparing stapled hemorrhoidopexy and Ferguson hemorrhoidectomy: perioperative and one-year results.Dis Colon Rectum2004. 47 (11):1824\u20131836."},{"issue":"3","key":"i0020-8868-97-2-112-Burch2","series-title":"Colorectal Dis","first-page":"233","article-title":"Stapled haemorrhoidopexy for the treatment of haemorrhoids: a systematic review.","volume":"11","author":"Burch\n              J","year":"2009","unstructured":"Burch\n              J\n            , EpsteinD, SariAB, WeatherlyH, JayneD, FoxD, et al. Stapled haemorrhoidopexy for the treatment of haemorrhoids: a systematic review.Colorectal Dis2009. 11 (3):233\u2013243. discussion 243."},{"issue":"3","key":"i0020-8868-97-2-112-Giordano1","series-title":"Arch Surg","first-page":"266","article-title":"Long-term outcomes of stapled hemorrhoidopexy vs conventional hemorrhoidectomy: a meta-analysis of randomized controlled trials.","volume":"144","author":"Giordano\n              P","year":"2009","unstructured":"Giordano\n              P\n            , GravanteG, SorgeR, OvensL, and NastroP. Long-term outcomes of stapled hemorrhoidopexy vs conventional hemorrhoidectomy: a meta-analysis of randomized controlled trials.Arch Surg2009. 144 (3):266\u2013272."},{"key":"i0020-8868-97-2-112-Longo1","series-title":"Treatment of haemorrhoidal disease by reduction of mucosa and haemorrhoidal prolapse with a circular suturing device: a new procedure. Proceedings of the 6th World Congress of Endoscopic Surgery (IFSES)","author":"Longo\n              A","year":"1998","unstructured":"Longo\n              A\n            \n          . Treatment of haemorrhoidal disease by reduction of mucosa and haemorrhoidal prolapse with a circular suturing device: a new procedure. Proceedings of the 6th World Congress of Endoscopic Surgery (IFSES). Bologna, ItalyMonduzzi Editore. 1998."},{"issue":"9206","key":"i0020-8868-97-2-112-Rowsell1","series-title":"Lancet","first-page":"779","article-title":"Circumferential mucosectomy (stapled haemorrhoidectomy) versus conventional haemorrhoidectomy: randomised controlled trial.","volume":"355","author":"Rowsell\n              M","year":"2000","unstructured":"Rowsell\n              M\n            , BelloM, and HemingwayDM. Circumferential mucosectomy (stapled haemorrhoidectomy) versus conventional haemorrhoidectomy: randomised controlled trial.Lancet2000. 355 (9206):779\u2013781."},{"issue":"3","key":"i0020-8868-97-2-112-Ho1","series-title":"Tech Coloproctol","first-page":"193","article-title":"Prospective randomized trial comparing stapled hemorrhoidopexy versus closed Ferguson hemorrhoidectomy.","volume":"10","author":"Ho\n              KS","year":"2006","unstructured":"Ho\n              KS\n             and HoYH. Prospective randomized trial comparing stapled hemorrhoidopexy versus closed Ferguson hemorrhoidectomy.Tech Coloproctol2006. 10 (3):193\u2013197."},{"issue":"3","key":"i0020-8868-97-2-112-Chen1","series-title":"Int J Colorectal Dis","first-page":"237","article-title":"Modified Longo's stapled hemorrhoidopexy with additional traction sutures for the treatment of residual prolapsed piles.","volume":"23","author":"Chen\n              CW","year":"2008","unstructured":"Chen\n              CW\n            , KangJC, WuCC, HsiaoCW, and JaoSW. Modified Longo's stapled hemorrhoidopexy with additional traction sutures for the treatment of residual prolapsed piles.Int J Colorectal Dis2008. 23 (3):237\u2013241."},{"issue":"8","key":"i0020-8868-97-2-112-Altomare1","series-title":"Dis Colon Rectum","first-page":"1102","article-title":"Treatment of external anorectal mucosal prolapse with a circular stapler: an easy and effective new surgical technique.","volume":"42","author":"Altomare\n              DF","year":"1999","unstructured":"Altomare\n              DF\n            , RinaldiM, ChiumaruloC, and PalascianoN. Treatment of external anorectal mucosal prolapse with a circular stapler: an easy and effective new surgical technique.Dis Colon Rectum1999. 42 (8):1102\u20131105."},{"issue":"11","key":"i0020-8868-97-2-112-Ho2","series-title":"Br J Surg","first-page":"1449","article-title":"Randomized trial assessing anal sphincter injuries after stapled haemorrhoidectomy.","volume":"88","author":"Ho\n              YH","year":"2001","unstructured":"Ho\n              YH\n            , Seow-ChoenF, TsangC, and EuKW. Randomized trial assessing anal sphincter injuries after stapled haemorrhoidectomy.Br J Surg2001. 88 (11):1449\u20131455."},{"issue":"12","key":"i0020-8868-97-2-112-Ho3","series-title":"Dis Colon Rectum","first-page":"1666","article-title":"Stapled hemorrhoidectomy\u2014cost and effectiveness. Randomized, controlled trial including incontinence scoring, anorectal manometry, and endoanal ultrasound assessments at up to three months.","volume":"43","author":"Ho\n              YH","year":"2000","unstructured":"Ho\n              YH\n            , CheongWK, TsangC, HoJ, EuKW, TangCL, et al. Stapled hemorrhoidectomy\u2014cost and effectiveness. Randomized, controlled trial including incontinence scoring, anorectal manometry, and endoanal ultrasound assessments at up to three months.Dis Colon Rectum2000. 43 (12):1666\u20131675."},{"issue":"9206","key":"i0020-8868-97-2-112-Mehigan1","series-title":"Lancet","first-page":"782","article-title":"Stapling procedure for haemorrhoids versus Milligan-Morgan haemorrhoidectomy: randomised controlled trial.","volume":"355","author":"Mehigan\n              BJ","year":"2000","unstructured":"Mehigan\n              BJ\n            , MonsonJR, and HartleyJE. Stapling procedure for haemorrhoids versus Milligan-Morgan haemorrhoidectomy: randomised controlled trial.Lancet2000. 355 (9206):782\u2013785."},{"issue":"2","key":"i0020-8868-97-2-112-Singer1","series-title":"Clin Colon Rectal Surg","first-page":"131","article-title":"Stapled hemorrhoidopexy: the argument for usage.","volume":"17","author":"Singer\n              M","year":"2004","unstructured":"Singer\n              M\n             and AbcarianH. Stapled hemorrhoidopexy: the argument for usage.Clin Colon Rectal Surg2004. 17 (2):131\u2013142."},{"issue":"7","key":"i0020-8868-97-2-112-Poh1","series-title":"World J Gastrointest Surg","first-page":"231","article-title":"Innovations in chronic anal fissure treatment: a systematic review.","volume":"2","author":"Poh\n              A","year":"2010","unstructured":"Poh\n              A\n            , TanKY, and Seow-ChoenF. Innovations in chronic anal fissure treatment: a systematic review.World J Gastrointest Surg2010. 2 (7):231\u2013241."},{"issue":"5","key":"i0020-8868-97-2-112-Bhardwaj1","series-title":"Ann R Coll Surg Engl","first-page":"472","article-title":"Modern perspectives in the treatment of chronic anal fissures.","volume":"89","author":"Bhardwaj\n              R","year":"2007","unstructured":"Bhardwaj\n              R\n             and ParkerMC. Modern perspectives in the treatment of chronic anal fissures.Ann R Coll Surg Engl2007. 89 (5):472\u2013478."},{"issue":"3","key":"i0020-8868-97-2-112-VanKemseke1","series-title":"Acta Gastroenterol Belg","first-page":"265","article-title":"Medical treatment of chronic anal fissure. Where do we stand on reversible chemical sphincterotomy?","volume":"67","author":"Van Kemseke\n              C","year":"2004","unstructured":"Van Kemseke\n              C\n             and BelaicheJ. Medical treatment of chronic anal fissure. Where do we stand on reversible chemical sphincterotomy?Acta Gastroenterol Belg2004. 67 (3):265\u2013271."},{"issue":"8","key":"i0020-8868-97-2-112-Ratnasingham1","series-title":"Int J Surg","first-page":"606","article-title":"Meta-analysis of the use of glyceryl trinitrate ointment after haemorrhoidectomy as an analgesic and in promoting wound healing.","volume":"8","author":"Ratnasingham\n              K","year":"2010","unstructured":"Ratnasingham\n              K\n            , UzzamanM, AndreaniSM, LightD, and PatelB. Meta-analysis of the use of glyceryl trinitrate ointment after haemorrhoidectomy as an analgesic and in promoting wound healing.Int J Surg2010. 8 (8):606\u2013611."},{"issue":"12","key":"i0020-8868-97-2-112-Tan1","series-title":"Br J Surg","first-page":"1464","article-title":"Randomized clinical trial of 0.2 per cent glyceryl trinitrate ointment for wound healing and pain reduction after open diathermy haemorrhoidectomy.","volume":"93","author":"Tan\n              KY","year":"2006","unstructured":"Tan\n              KY\n            , SngKK, TayKH, LaiJH, and EuKW. Randomized clinical trial of 0.2 per cent glyceryl trinitrate ointment for wound healing and pain reduction after open diathermy haemorrhoidectomy.Br J Surg2006. 93 (12):1464\u20131468."},{"issue":"1","key":"i0020-8868-97-2-112-Patti1","series-title":"Chir Ital","first-page":"77","article-title":"Efficacy of topical use of 0.2% glyceryl trinitrate in reducing post-haemorrhoidectomy pain and improving wound healing [in Italian].","volume":"57","author":"Patti\n              R","year":"2005","unstructured":"Patti\n              R\n            , ArcaraM, PadronaggioD, BonventreS, AngileriM, SalernoR, et al. Efficacy of topical use of 0.2% glyceryl trinitrate in reducing post-haemorrhoidectomy pain and improving wound healing [in Italian].Chir Ital2005. 57 (1):77\u201385."},{"issue":"2","key":"i0020-8868-97-2-112-Karanlik1","series-title":"Dis Colon Rectum","first-page":"280","article-title":"The effect of glyceryl trinitrate ointment on posthemorrhoidectomy pain and wound healing: results of a randomized, double-blind, placebo-controlled study.","volume":"52","author":"Karanlik\n              H","year":"2009","unstructured":"Karanlik\n              H\n            , AkturkR, CamlicaH, and AsogluO. The effect of glyceryl trinitrate ointment on posthemorrhoidectomy pain and wound healing: results of a randomized, double-blind, placebo-controlled study.Dis Colon Rectum2009. 52 (2):280\u2013285."},{"issue":"7","key":"i0020-8868-97-2-112-Hwang1","series-title":"Dis Colon Rectum","first-page":"950","article-title":"Effect of 0.2 percent glyceryl trinitrate ointment on wound healing after a hemorrhoidectomy: results of a randomized, prospective, double-blind, placebo-controlled trial.","volume":"46","author":"Hwang\n              DY","year":"2003","unstructured":"Hwang\n              DY\n            , YoonSG, KimHS, LeeJK, and KimKY. Effect of 0.2 percent glyceryl trinitrate ointment on wound healing after a hemorrhoidectomy: results of a randomized, prospective, double-blind, placebo-controlled trial.Dis Colon Rectum2003. 46 (7):950\u2013954."},{"issue":"2","key":"i0020-8868-97-2-112-Thaha1","series-title":"Br J Surg","first-page":"208","article-title":"Postdefaecation pain syndrome after circular stapled anopexy is abolished by oral nifedipine.","volume":"92","author":"Thaha\n              MA","year":"2005","unstructured":"Thaha\n              MA\n            , IrvineLA, SteeleRJ, and CampbellKL. Postdefaecation pain syndrome after circular stapled anopexy is abolished by oral nifedipine.Br J Surg2005. 92 (2):208\u2013210."},{"issue":"3","key":"i0020-8868-97-2-112-Ho4","series-title":"Br J Surg","first-page":"377","article-title":"Randomized controlled trial of trimebutine (anal sphincter relaxant) for pain after haemorrhoidectomy.","volume":"84","author":"Ho\n              YH","year":"1997","unstructured":"Ho\n              YH\n            , Seow-ChoenF, LowJY, TanM, and LeongAP. Randomized controlled trial of trimebutine (anal sphincter relaxant) for pain after haemorrhoidectomy.Br J Surg1997. 84 (3):377\u2013379."},{"issue":"6","key":"i0020-8868-97-2-112-Thornton1","series-title":"Dis Colon Rectum","first-page":"1207","article-title":"Manometric effect of topical glyceryl trinitrate and its impact on chronic anal fissure healing.","volume":"48","author":"Thornton\n              MJ","year":"2005","unstructured":"Thornton\n              MJ\n            , KennedyML, and KingDW. Manometric effect of topical glyceryl trinitrate and its impact on chronic anal fissure healing.Dis Colon Rectum2005. 48 (6):1207\u20131212."},{"issue":"5","key":"i0020-8868-97-2-112-Tjandra1","series-title":"Colorectal Dis","first-page":"457","article-title":"Rectogesic (glyceryl trinitrate 0.2%) ointment relieves symptoms of haemorrhoids associated with high resting anal canal pressures.","volume":"9","author":"Tjandra\n              JJ","year":"2007","unstructured":"Tjandra\n              JJ\n            , TanJJ, LimJF, Murray-GreenC, KennedyML, and LubowskiDZ. Rectogesic (glyceryl trinitrate 0.2%) ointment relieves symptoms of haemorrhoids associated with high resting anal canal pressures.Colorectal Dis2007. 9 (5):457\u2013463."},{"issue":"6","key":"i0020-8868-97-2-112-Tjandra2","series-title":"Dis Colon Rectum","first-page":"878","article-title":"Systematic review on the procedure for prolapse and hemorrhoids (stapled hemorrhoidopexy).","volume":"50","author":"Tjandra\n              JJ","year":"2007","unstructured":"Tjandra\n              JJ\n             and ChanMK. Systematic review on the procedure for prolapse and hemorrhoids (stapled hemorrhoidopexy).Dis Colon Rectum2007. 50 (6):878\u2013892."}],"container-title":["International Surgery"],"original-title":[],"link":[{"URL":"https:\/\/international-surgery.kglmeridian.com\/view\/journals\/insu\/97\/2\/article-p112.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/international-surgery\/article-pdf\/97\/2\/112\/2214027\/cc92_1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/international-surgery.kglmeridian.com\/downloadpdf\/journals\/insu\/97\/2\/article-p112.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/international-surgery.kglmeridian.com\/downloadpdf\/journals\/insu\/97\/2\/article-p112.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T19:04:34Z","timestamp":1751483074000},"score":1,"resource":{"primary":{"URL":"https:\/\/international-surgery.kglmeridian.com\/view\/journals\/insu\/97\/2\/article-p112.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":28,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.9738\/cc92.1","relation":{},"ISSN":["0020-8868","2520-2456"],"issn-type":[{"value":"0020-8868","type":"print"},{"value":"2520-2456","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}