{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T03:26:23Z","timestamp":1768965983822,"version":"3.49.0"},"reference-count":11,"publisher":"International College of Surgeons","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:title>Abstract<\/jats:title>\n        <jats:p>The aim of this study was to evaluate the efficacy of vaginal misoprostol for cervical priming at doses of 200 mcg and 400 mcg, 12 to 15 hours before diagnostic office hysteroscopy (OH) without anesthesia in patients with infertility. Sixty infertile patients requiring a diagnostic office hysteroscopy for investigation of infertility were included in the study. The patients were randomly allocated into 3 vaginally administered misoprostol groups: (1) control group, (2) 200-mcg dose group, and (3) 400-mcg dose group. Misoprostol significantly facilitated the procedure of OH: cervical entry was easier; procedural time was shorter; baseline cervical width was larger; and pain scoring was lower in the misoprostol groups compared with the control group. Increasing the dose of misoprostol from 200 mcg to 400 mcg did not improve the effect on cervical dilation. Misoprostol is a promising analog to use for cervical priming before OH. Since doses of 200 mcg and 400 mcg vaginal misoprostol 12 hours before the OH both have proven to be effective regimens, 200 mcg may be preferred. However, before routine clinical usage, further research is needed through large, randomized, controlled trials powered to detect a difference in complications to determine whether misoprostol reduces complications in OH.<\/jats:p>","DOI":"10.9738\/intsurg-d-12-00024.1","type":"journal-article","created":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T14:58:28Z","timestamp":1369321108000},"page":"140-144","source":"Crossref","is-referenced-by-count":20,"title":["Cervical Priming Before Diagnostic Operative Hysteroscopy in Infertile Women: A Randomized, Double-Blind, Controlled Comparison of 2 Vaginal Misoprostol Doses"],"prefix":"10.9738","volume":"98","author":[{"given":"Ercan","family":"Bastu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Istanbul University School of Medicine, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cem","family":"Celik","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Namik Kemal University School of Medicine, Tekirdag, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asli","family":"Nehir","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Istanbul University School of Medicine, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Dogan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Istanbul University School of Medicine, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahar","family":"Yuksel","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Istanbul University School of Medicine, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bulent","family":"Ergun","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Istanbul University School of Medicine, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4721","reference":[{"issue":"2","key":"i0020-8868-98-2-140-b01","series-title":"Obstet Gynecol","first-page":"266","article-title":"Complications of hysteroscopy: a prospective, multicenter study","volume":"96","author":"Jansen\n              FW,","year":"2000","unstructured":"Jansen\n              FW, \n            \n              Vredevoogd\n              CB, \n            \n              van Ulzen\n              K, \n            \n              Hermans\n              J, \n            \n              Trimbos\n              JB, \n            \n              Trimbos-Kemper\n              TC. \n          \n          Complications of hysteroscopy: a prospective, multicenter study. Obstet Gynecol2000;96(2):266\u2013270"},{"issue":"12","key":"i0020-8868-98-2-140-b02","series-title":"Hum Reprod","first-page":"3036","article-title":"Investigation and treatment of repeated implantation failure following IVF-ET","volume":"21","author":"Margalioth\n              EJ,","year":"2006","unstructured":"Margalioth\n              EJ, \n            \n              Ben-Chetrit\n              A, \n            \n              Gal\n              M, \n            \n              Eldar-Geva\n              T. \n          \n          Investigation and treatment of repeated implantation failure following IVF-ET. Hum Reprod2006;21(12):3036\u20133043"},{"issue":"7","key":"i0020-8868-98-2-140-b03","series-title":"Fertil Steril","first-page":"2400","article-title":"Sublingual misoprostol for cervical ripening before diagnostic hysteroscopy in premenopausal women: a randomized, double blind, placebo-controlled trial","volume":"93","author":"Mulayim\n              B,","year":"2010","unstructured":"Mulayim\n              B, \n            \n              Celik\n              NY, \n            \n              Onalan\n              G, \n            \n              Bagis\n              T, \n            \n              Zeyneloglu\n              HB. \n          \n          Sublingual misoprostol for cervical ripening before diagnostic hysteroscopy in premenopausal women: a randomized, double blind, placebo-controlled trial. Fertil Steril2010;93(7):2400\u20132404"},{"issue":"8","key":"i0020-8868-98-2-140-b04","series-title":"Hum Reprod","first-page":"1942","article-title":"The use of misoprostol before hysteroscopic surgery in non-pregnant premenopausal women: a randomized comparison of sublingual, oral and vaginal administrations","volume":"25","author":"Lee\n              YY,","year":"2010","unstructured":"Lee\n              YY, \n            \n              Kim\n              TJ, \n            \n              Kang\n              H, \n            \n              Choi\n              CH, \n            \n              Lee\n              JW, \n            \n              Kim\n              BG\n            \n            et al\n          . The use of misoprostol before hysteroscopic surgery in non-pregnant premenopausal women: a randomized comparison of sublingual, oral and vaginal administrations. Hum Reprod2010;25(8):1942\u20131948"},{"key":"i0020-8868-98-2-140-b05","series-title":"Lancet","first-page":"1127","article-title":"Measurement of pain","volume":"2","author":"Huskisson\n              EC.","year":"1974","unstructured":"Huskisson\n              EC. \n          \n          Measurement of pain. Lancet1974;2:1127\u20131131"},{"issue":"5","key":"i0020-8868-98-2-140-b06","series-title":"Am J Obstet Gynecol","first-page":"876","article-title":"The use of oral misoprostol as a cervical ripening agent in operative hysteroscopy: a double-blind, placebo-controlled trial","volume":"186","author":"Thomas\n              JA,","year":"2002","unstructured":"Thomas\n              JA, \n            \n              Leyland\n              N, \n            \n              Durand\n              N, \n            \n              Windrim\n              RC. \n          \n          The use of oral misoprostol as a cervical ripening agent in operative hysteroscopy: a double-blind, placebo-controlled trial. Am J Obstet Gynecol2002;186(5):876\u2013879"},{"issue":"7","key":"i0020-8868-98-2-140-b07","series-title":"Hum Reprod","first-page":"1618","article-title":"Vaginal misoprostol for cervical ripening before operative hysteroscopy in pre-menopausal women: a double-blind, placebo-controlled trial with three dose regimens","volume":"19","author":"Fernandez\n              H,","year":"2004","unstructured":"Fernandez\n              H, \n            \n              Alby\n              JD, \n            \n              Tournoux\n              C, \n            \n              Chauveaud-Lambling\n              A, \n            \n              DeTayrac\n              R, \n            \n              Frydman\n              R\n            \n            et al\n          . Vaginal misoprostol for cervical ripening before operative hysteroscopy in pre-menopausal women: a double-blind, placebo-controlled trial with three dose regimens. 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Br J Obstet Gynaecol2008;115(5):663, e1\u20139"},{"issue":"2","key":"i0020-8868-98-2-140-b09","series-title":"Fertil Steril","first-page":"759","article-title":"Effectiveness of misoprostol for office hysteroscopy without anesthesia in infertile patients","volume":"95","author":"Sordia-Hern\u00e1ndez\n              LH,","year":"2011","unstructured":"Sordia-Hern\u00e1ndez\n              LH, \n            \n              Rosales-Tristan\n              E, \n            \n              Vazquez-Mendez\n              J, \n            \n              Merino\n              M, \n            \n              Iglesias\n              JL, \n            \n              Garza-Leal\n              JG\n            \n            et al\n          . Effectiveness of misoprostol for office hysteroscopy without anesthesia in infertile patients. Fertil Steril2011;95(2):759\u2013761"},{"issue":"4","key":"i0020-8868-98-2-140-b10","series-title":"Fertil Steril","first-page":"962","article-title":"A double-blind randomized controlled trial of vaginal misoprostol for cervical priming before outpatient hysteroscopy","volume":"96","author":"El-Mazny\n              A,","year":"2011","unstructured":"El-Mazny\n              A, \n            \n              Abou-Salem\n              N. \n          \n          A double-blind randomized controlled trial of vaginal misoprostol for cervical priming before outpatient hysteroscopy. Fertil Steril2011;96(4):962\u2013965"},{"issue":"3","key":"i0020-8868-98-2-140-b11","series-title":"Int J Gynaecol Obstet","first-page":"263","article-title":"Misoprostol for cervical ripening before diagnostic hysteroscopy in nulliparous women","volume":"116","author":"Bakas\n              P,","year":"2012","unstructured":"Bakas\n              P, \n            \n              Hassiakos\n              D, \n            \n              Liapis\n              A, \n            \n              Creatsa\n              M, \n            \n              Konidaris\n              S, \n            \n              Gregoriou\n              O. \n          \n          Misoprostol for cervical ripening before diagnostic hysteroscopy in nulliparous women. Int J Gynaecol Obstet2012;116(3):263\u2013264"}],"container-title":["International Surgery"],"original-title":[],"link":[{"URL":"https:\/\/international-surgery.kglmeridian.com\/view\/journals\/insu\/98\/2\/article-p140.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/international-surgery\/article-pdf\/98\/2\/140\/2214194\/intsurg-d-12-00024_1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/international-surgery.kglmeridian.com\/downloadpdf\/journals\/insu\/98\/2\/article-p140.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/international-surgery.kglmeridian.com\/downloadpdf\/journals\/insu\/98\/2\/article-p140.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T18:59:36Z","timestamp":1751482776000},"score":1,"resource":{"primary":{"URL":"https:\/\/international-surgery.kglmeridian.com\/view\/journals\/insu\/98\/2\/article-p140.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":11,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.9738\/intsurg-d-12-00024.1","relation":{},"ISSN":["0020-8868","2520-2456"],"issn-type":[{"value":"0020-8868","type":"print"},{"value":"2520-2456","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}