{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T19:40:03Z","timestamp":1751485203842,"version":"3.41.0"},"reference-count":19,"publisher":"International College of Surgeons","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:title>Abstract<\/jats:title>\n        <jats:p>A 59-year-old male with hepatocellular carcinoma (HCC) due to liver cirrhosis caused by the hepatitis C virus underwent cadaveric whole liver transplantation. Two years later, he had a metastatic HCC in the superior mediastinum. Over the following postoperative year, he underwent transcatheter arterial chemoembolization (TACE) for 4 tumors in the implanted liver. In the third post-TACE month, he was emergently hospitalized due to intracerebral hematoma with a tumor invading the bone in the medial frontal segment. He underwent emergency intracranial tumorectomy and hemorrhage removal. The histopathologic diagnosis was metastatic HCC. He regained consciousness as well as the ability to speak and to feed himself, resulting in an improved quality of life. The incidence of HCC recurrence after liver transplantation is observed in approximately 8% to 11% of selected cases, with frequent relapses observed in the implanted liver, bones, adrenal glands, and lungs. Mediastinal and intracranial metastases from HCC post-liver transplantation are very rare.<\/jats:p>","DOI":"10.9738\/intsurg-d-13-00026.1","type":"journal-article","created":{"date-parts":[[2013,11,14]],"date-time":"2013-11-14T15:04:38Z","timestamp":1384441478000},"page":"432-436","source":"Crossref","is-referenced-by-count":2,"title":["Two Rare Metachronous Metastases of Hepatocellular Carcinoma After Liver Transplantation"],"prefix":"10.9738","volume":"98","author":[{"given":"Satoshi","family":"Shinya","sequence":"first","affiliation":[{"name":"Department of Gastroenterological Surgery, Fukuoka University School of Medicine, Jonan-ku, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoaki","family":"Noritomi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Fukuoka University School of Medicine, Jonan-ku, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Yamauchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Fukuoka University School of Medicine, Jonan-ku, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takamistu","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Fukuoka University School of Medicine, Jonan-ku, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Hamada","sequence":"additional","affiliation":[{"name":"Department of Pathology, Fukuoka University School of Medicine, Jonan-ku, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Fukuoka University School of Medicine, Jonan-ku, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4721","reference":[{"issue":"suppl 1","key":"i0020-8868-98-4-432-b01","series-title":"Gastroenterology","first-page":"S159","article-title":"Treatment of hepatocellular carcinoma by percutaneous tumor ablation methods: ethanol injection therapy and radiofrequency ablation","volume":"127","author":"Omata\n              M,","year":"2004","unstructured":"Omata\n              M, \n            \n              Tateishi\n              R, \n            \n              Yoshida\n              H, \n            \n              Shiina\n              S. \n          \n          Treatment of hepatocellular carcinoma by percutaneous tumor ablation methods: ethanol injection therapy and radiofrequency ablation. Gastroenterology2004;127(suppl 1):S159\u2013S166"},{"issue":"3","key":"i0020-8868-98-4-432-b02","series-title":"World J Gastroenterol","first-page":"414","article-title":"Clinical features and prognosis of patients with extrahepatic metastases from hepatocellular carcinoma","volume":"13","author":"Uka\n              K,","year":"2007","unstructured":"Uka\n              K, \n            \n              Aikata\n              H, \n            \n              Takaki\n              S, \n            \n              Shirakawa\n              H, \n            \n              Jeong\n              SC, \n            \n              Yamashina\n              K\n            \n            et al\n          . Clinical features and prognosis of patients with extrahepatic metastases from hepatocellular carcinoma. World J Gastroenterol2007;13(3):414\u2013420"},{"issue":"8","key":"i0020-8868-98-4-432-b03","series-title":"World J Surg","first-page":"1738","article-title":"Clinical features of hepatocellular carcinoma developing extrahepatic recurrences after curative resection","volume":"32","author":"Tanaka\n              K,","year":"2008","unstructured":"Tanaka\n              K, \n            \n              Shimada\n              H, \n            \n              Matsuo\n              K, \n            \n              Takeda\n              K, \n            \n              Nagano\n              Y, \n            \n              Togo\n              S. \n          \n          Clinical features of hepatocellular carcinoma developing extrahepatic recurrences after curative resection. World J Surg2008;32(8):1738\u20131747"},{"issue":"11","key":"i0020-8868-98-4-432-b04","series-title":"J Gastroenterol Hepatol","first-page":"1781","article-title":"Clinical features of hepatocellular carcinoma with extrahepatic metastases","volume":"20","author":"Natsuizaka\n              M,","year":"2005","unstructured":"Natsuizaka\n              M, \n            \n              Omura\n              T, \n            \n              Akaike\n              T, \n            \n              Kuwata\n              Y, \n            \n              Yamazaki\n              K, \n            \n              Sato\n              T\n            \n            et al\n          . Clinical features of hepatocellular carcinoma with extrahepatic metastases. J Gastroenterol Hepatol2005;20(11):1781\u20131787"},{"issue":"2","key":"i0020-8868-98-4-432-b05","series-title":"Surg Neurol","first-page":"172","article-title":"Intracranial metastasis of hepatocellular carcinoma: review of 45 cases","volume":"62","author":"Chang\n              L,","year":"2004","unstructured":"Chang\n              L, \n            \n              Chen\n              YL, \n            \n              Kao\n              MC. \n          \n          Intracranial metastasis of hepatocellular carcinoma: review of 45 cases. Surg Neurol2004;62(2):172\u2013177"},{"issue":"3 suppl","key":"i0020-8868-98-4-432-b06","series-title":"Transplantation","first-page":"S37","article-title":"Living-donor liver transplantation for hepatocellular carcinoma","volume":"75","author":"Kaihara\n              S,","year":"2003","unstructured":"Kaihara\n              S, \n            \n              Kiuchi\n              T, \n            \n              Ueda\n              M, \n            \n              Oike\n              F, \n            \n              Fujimoto\n              Y, \n            \n              Ogawa\n              K\n            \n            et al\n          . Living-donor liver transplantation for hepatocellular carcinoma. Transplantation2003;75(3 suppl):S37\u2013S40"},{"issue":"7","key":"i0020-8868-98-4-432-b07","series-title":"Br J Surg","first-page":"1019","article-title":"Resection for extrahepatic recurrence of hepatocellular carcinoma","volume":"81","author":"Lo\n              CM,","year":"1994","unstructured":"Lo\n              CM, \n            \n              Lai\n              EC, \n            \n              Fan\n              ST, \n            \n              Choi\n              TK, \n            \n              Wong\n              J. \n          \n          Resection for extrahepatic recurrence of hepatocellular carcinoma. Br J Surg1994;81(7):1019\u20131021"},{"issue":"3","key":"i0020-8868-98-4-432-b08","series-title":"J Am Coll Surg","first-page":"311","article-title":"Aggressive management of patients with extrahepatic and intrahepatic recurrences of hepatocellular carcinoma by combined resection and locoregional therapy","volume":"195","author":"Poon\n              RT,","year":"2002","unstructured":"Poon\n              RT, \n            \n              Fan\n              ST, \n            \n              O'Suilleabhain\n              CB, \n            \n              Wong\n              J. \n          \n          Aggressive management of patients with extrahepatic and intrahepatic recurrences of hepatocellular carcinoma by combined resection and locoregional therapy. J Am Coll Surg2002;195(3):311\u2013318"},{"issue":"2","key":"i0020-8868-98-4-432-b09","series-title":"Surgery","first-page":"196","article-title":"Patterns and clinicopathologic features of extrahepatic recurrence of hepatocellular carcinoma after curative resection","volume":"141","author":"Yang\n              Y,","year":"2007","unstructured":"Yang\n              Y, \n            \n              Nagano\n              H, \n            \n              Ota\n              H, \n            \n              Morimoto\n              O, \n            \n              Nakamura\n              M, \n            \n              Wada\n              H\n            \n            et al\n          . Patterns and clinicopathologic features of extrahepatic recurrence of hepatocellular carcinoma after curative resection. Surgery2007;141(2):196\u2013202"},{"issue":"3","key":"i0020-8868-98-4-432-b10","series-title":"Gastroenterology","first-page":"720","article-title":"Prognosis of recurrent hepatocellular carcinoma: a 10-year surgical experience in Japan","volume":"111","author":"Shimada\n              M,","year":"1996","unstructured":"Shimada\n              M, \n            \n              Takenaka\n              K, \n            \n              Gion\n              T, \n            \n              Fujiwara\n              Y, \n            \n              Kajiyama\n              K, \n            \n              Maeda\n              T\n            \n            et al\n          . Prognosis of recurrent hepatocellular carcinoma: a 10-year surgical experience in Japan. Gastroenterology1996;111(3):720\u2013726"},{"issue":"3","key":"i0020-8868-98-4-432-b11","series-title":"Arq Gastroenterol","first-page":"199","article-title":"Brain metastasis of hepatocellular carcinoma detected after liver transplantation","volume":"41","author":"Franca\n              AV,","year":"2004","unstructured":"Franca\n              AV, \n            \n              Martinelli\n              A, \n            \n              Silva\n              OC\n              Jr. \n          \n          Brain metastasis of hepatocellular carcinoma detected after liver transplantation. Arq Gastroenterol2004;41(3):199\u2013201"},{"issue":"7","key":"i0020-8868-98-4-432-b12","series-title":"Thorac Cardiovasc Surg","first-page":"463","article-title":"Pancoast syndrome caused by metastasis to the superior mediastinum of hepatocellular carcinoma","volume":"55","author":"Hung\n              JJ,","year":"2007","unstructured":"Hung\n              JJ, \n            \n              Lin\n              SC, \n            \n              Hsu\n              WH. \n          \n          Pancoast syndrome caused by metastasis to the superior mediastinum of hepatocellular carcinoma. Thorac Cardiovasc Surg2007;55(7):463\u2013465"},{"issue":"4","key":"i0020-8868-98-4-432-b13","series-title":"Nippon Kyobu Geka Gakkai Zasshi","first-page":"709","article-title":"A case of metastatic hepatocellular carcinoma of the superior mediastinum","volume":"41","author":"Yamashita\n              R,","year":"1993","unstructured":"Yamashita\n              R, \n            \n              Takahashi\n              M, \n            \n              Kosugi\n              M, \n            \n              Kobayashi\n              C, \n            \n              Annen\n              Y. \n          \n          A case of metastatic hepatocellular carcinoma of the superior mediastinum. Nippon Kyobu Geka Gakkai Zasshi1993;41(4):709\u2013713"},{"issue":"3","key":"i0020-8868-98-4-432-b14","series-title":"J Neurooncol","first-page":"307","article-title":"Brain metastases from hepatocellular carcinoma: prognostic factors and outcome: brain metastasis from HCC","volume":"91","author":"Choi\n              HJ,","year":"2009","unstructured":"Choi\n              HJ, \n            \n              Cho\n              BC, \n            \n              Sohn\n              JH, \n            \n              Shin\n              SJ, \n            \n              Kim\n              SH, \n            \n              Kim\n              JH\n            \n            et al\n          . Brain metastases from hepatocellular carcinoma: prognostic factors and outcome: brain metastasis from HCC. J Neurooncol2009;91(3):307\u2013313"},{"issue":"3","key":"i0020-8868-98-4-432-b15","series-title":"Tokai J Exp Clin Med","first-page":"105","article-title":"A case report: tumorectomy for brain metastasis of hepatocellular carcinoma","volume":"24","author":"Moriya\n              H,","year":"1999","unstructured":"Moriya\n              H, \n            \n              Ohtani\n              Y, \n            \n              Tsukui\n              M, \n            \n              Tanaka\n              Y, \n            \n              Tajima\n              T, \n            \n              Makuuchi\n              H\n            \n            et al\n          . A case report: tumorectomy for brain metastasis of hepatocellular carcinoma. Tokai J Exp Clin Med1999;24(3):105\u2013110"},{"issue":"13","key":"i0020-8868-98-4-432-b16","series-title":"Hepatogastroenterology","first-page":"251","article-title":"Prognosis of hepatocellular carcinoma patients with extrahepatic metastases","volume":"44","author":"Okusaka\n              T,","year":"1997","unstructured":"Okusaka\n              T, \n            \n              Okada\n              S, \n            \n              Ishii\n              H, \n            \n              Nose\n              H, \n            \n              Nagahama\n              H, \n            \n              Nakasuka\n              H\n            \n            et al\n          . Prognosis of hepatocellular carcinoma patients with extrahepatic metastases. Hepatogastroenterology1997;44(13):251\u2013257"},{"issue":"9","key":"i0020-8868-98-4-432-b17","series-title":"Br J Surg","first-page":"1198","article-title":"Prolonged survival in selected patients following surgical resection for pulmonary metastasis from hepatocellular carcinoma","volume":"85","author":"Lam\n              CM,","year":"1998","unstructured":"Lam\n              CM, \n            \n              Lo\n              CM, \n            \n              Yuen\n              WK, \n            \n              Liu\n              CL, \n            \n              Fan\n              ST. \n          \n          Prolonged survival in selected patients following surgical resection for pulmonary metastasis from hepatocellular carcinoma. Br J Surg1998;85(9):1198\u20131200"},{"issue":"4","key":"i0020-8868-98-4-432-b18","series-title":"Dig Surg","first-page":"294","article-title":"Treatment of adrenal metastases after hepatic resection of a hepatocellular carcinoma","volume":"18","author":"Shuto\n              T,","year":"2001","unstructured":"Shuto\n              T, \n            \n              Hirohashi\n              K, \n            \n              Kubo\n              S, \n            \n              Tanaka\n              H, \n            \n              Yamamoto\n              T, \n            \n              Higaki\n              I\n            \n            et al\n          . Treatment of adrenal metastases after hepatic resection of a hepatocellular carcinoma. Dig Surg2001;18(4):294\u2013297"},{"issue":"22","key":"i0020-8868-98-4-432-b19","series-title":"Intern Med","first-page":"1993","article-title":"Brain metastasis from hepatocellular carcinoma treated with a cyber-knife","volume":"47","author":"Hiraoka\n              A,","year":"2008","unstructured":"Hiraoka\n              A, \n            \n              Horiike\n              N, \n            \n              Koizumi\n              Y, \n            \n              Tazuya\n              N, \n            \n              Ichiryu\n              M, \n            \n              Nakahara\n              H\n            \n            et al\n          . Brain metastasis from hepatocellular carcinoma treated with a cyber-knife. Intern Med2008;47(22):1993\u20131996"}],"container-title":["International Surgery"],"original-title":[],"link":[{"URL":"https:\/\/international-surgery.kglmeridian.com\/view\/journals\/insu\/98\/4\/article-p432.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/international-surgery\/article-pdf\/98\/4\/432\/2347635\/intsurg-d-13-00026_1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/international-surgery.kglmeridian.com\/downloadpdf\/journals\/insu\/98\/4\/article-p432.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/international-surgery.kglmeridian.com\/downloadpdf\/journals\/insu\/98\/4\/article-p432.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T19:08:34Z","timestamp":1751483314000},"score":1,"resource":{"primary":{"URL":"https:\/\/international-surgery.kglmeridian.com\/view\/journals\/insu\/98\/4\/article-p432.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":19,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.9738\/intsurg-d-13-00026.1","relation":{},"ISSN":["0020-8868","2520-2456"],"issn-type":[{"type":"print","value":"0020-8868"},{"type":"electronic","value":"2520-2456"}],"subject":[],"published":{"date-parts":[[2013]]}}}