{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T02:00:38Z","timestamp":1760061638345,"version":"3.41.0"},"reference-count":25,"publisher":"International College of Surgeons","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:title>Abstract<\/jats:title>\n        <jats:p>Malignant tumors with mixed glandular and neuroendocrine characteristics with at least 30% of each component are classified as mixed adenoneuroendocrine carcinoma (MANEC) by the World Health Organization 2010 classification. We report here a case of very well-differentiated adenocarcinoma accompanied by carcinoid tumor, categorized as MANEC. A 41-year-old Japanese man was clinically diagnosed with ascending colon cancer and underwent right hemicolectomy. Using an immunohistologic technique, the pathologic diagnosis was very well-differentiated adenocarcinoma accompanied by carcinoid tumor and marked eosinophil infiltration, which was categorized as MANEC. By immunohistochemical analysis, tumor cells of the carcinoid component exhibited very low proliferation activity. Our case was thought to be MANEC without high malignant potential. MANEC as per the World Health Organization 2010 classification seems to include tumors with diverse grades of malignancy, and it might need to have subclassifications according to the malignancy potential of the tumor cells.<\/jats:p>","DOI":"10.9738\/intsurg-d-13-00041.1","type":"journal-article","created":{"date-parts":[[2014,3,26]],"date-time":"2014-03-26T20:44:34Z","timestamp":1395866674000},"page":"132-136","source":"Crossref","is-referenced-by-count":18,"title":["A Case of Very Well-Differentiated Adenocarcinoma With Carcinoid Tumor in the Ascending Colon"],"prefix":"10.9738","volume":"99","author":[{"given":"Hayato","family":"Yamauchi","sequence":"first","affiliation":[{"name":"Department of Surgery, Social Insurance Gunma Chuo General Hospital, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, Social Insurance Gunma Chuo General Hospital, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritsuko","family":"Tsukagoshi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Social Insurance Gunma Chuo General Hospital, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Surgery, Social Insurance Gunma Chuo General Hospital, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Tabe","sequence":"additional","affiliation":[{"name":"Department of Surgery, Social Insurance Gunma Chuo General Hospital, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaharu","family":"Fukasawa","sequence":"additional","affiliation":[{"name":"Department of Surgery, Social Insurance Gunma Chuo General Hospital, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinsuke","family":"Kiriyama","sequence":"additional","affiliation":[{"name":"Department of Surgery, Social Insurance Gunma Chuo General Hospital, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Fukuchi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Social Insurance Gunma Chuo General Hospital, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Naitoh","sequence":"additional","affiliation":[{"name":"Department of Surgery, Social Insurance Gunma Chuo General Hospital, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Kuwano","sequence":"additional","affiliation":[{"name":"Department of General Surgical Science (Surgery I), Gunma University Graduate School of Medicine, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4721","reference":[{"key":"i0020-8868-99-2-132-b01","series-title":"Ann N Y Acad Sci","first-page":"13","article-title":"The gastroenteropancreatic neuroendocrine cell system and its tumors: the WHO classification","volume":"1014","author":"Kloppel\n              G,","year":"2004","unstructured":"Kloppel\n              G, \n            \n              Perren\n              A, \n            \n              Heitz\n              PU. \n          \n          The gastroenteropancreatic neuroendocrine cell system and its tumors: the WHO classification. 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