{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T19:40:05Z","timestamp":1751485205071,"version":"3.41.0"},"reference-count":15,"publisher":"International College of Surgeons","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:title>Abstract<\/jats:title>\n        <jats:p>We report on a large, retroperitoneal, malignant, solitary fibrous tumor (SFT) with high proliferation activity. A 43-year-old man was admitted to our department complaining of a palpable mass. Computed tomography (CT) and magnetic resonance imaging (MRI) revealed a large retroperitoneal tumor occupying the entire abdominal cavity. A laparotomy was performed for diagnosis and treatment, which revealed a tumor in the retroperitoneum but with no invasion to the surrounding organs, thereby allowing safe macroscopic excision. Histologically, the tumor was composed of spindle-shaped cells with patternless pattern and a hemangiopericytomatous appearance. Moreover, immunohistochemical staining was positive for CD34, vimentin, Bcl-2, and CD99 and negative for desmin, S-100p, and smooth muscle actin (AMA). The tumor exhibited high cellularity, moderate mitotic activity, pleomorphism, necrosis, and hemorrhagic changes. In addition, the Ki-67 labeling index was 37%. These findings confirmed the diagnosis of malignant SFT with high proliferation activity. Subsequently, adjuvant doxorubicin plus ifosfamide chemotherapy was performed. No signs of recurrence were observed 12 months after the surgery.<\/jats:p>","DOI":"10.9738\/intsurg-d-13-00087.1","type":"journal-article","created":{"date-parts":[[2014,7,24]],"date-time":"2014-07-24T19:24:38Z","timestamp":1406229878000},"page":"414-418","source":"Crossref","is-referenced-by-count":5,"title":["A Large Retroperitoneal Malignant Solitary Fibrous Tumor"],"prefix":"10.9738","volume":"99","author":[{"given":"Tomoaki","family":"Yoh","sequence":"first","affiliation":[{"name":"Department of Surgery, Yamatotakada Municipal Hospital, Yamatotakada, Nara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritsuko","family":"Sata","sequence":"additional","affiliation":[{"name":"Department of Surgery, Yamatotakada Municipal Hospital, Yamatotakada, Nara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Yamatotakada Municipal Hospital, Yamatotakada, Nara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seidai","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Surgery, Yamatotakada Municipal Hospital, Yamatotakada, Nara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuya","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Surgery, Yamatotakada Municipal Hospital, Yamatotakada, Nara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsushi","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Surgery, Yamatotakada Municipal Hospital, Yamatotakada, Nara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Surgery, Yamatotakada Municipal Hospital, Yamatotakada, Nara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuji","family":"Okamura","sequence":"additional","affiliation":[{"name":"Department of Surgery, Yamatotakada Municipal Hospital, Yamatotakada, Nara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4721","reference":[{"issue":"1","key":"i0020-8868-99-4-414-b01","series-title":"Am J Ind Med","first-page":"1","article-title":"Primary neoplasms of the pleura: a report of five cases","volume":"22","author":"Klemperer\n              P,","year":"1992","unstructured":"Klemperer\n              P, \n            \n              Coleman\n              BR. \n          \n          Primary neoplasms of the pleura: a report of five cases. Am J Ind Med1992;22(1):1\u201331"},{"issue":"1","key":"i0020-8868-99-4-414-b02","series-title":"Surg Today","first-page":"90","article-title":"Large solitary fibrous tumor of the retroperitoneum: report of a case","volume":"34","author":"Kunieda\n              K,","year":"2004","unstructured":"Kunieda\n              K, \n            \n              Tanaka\n              Y, \n            \n              Nagao\n              N, \n            \n              Yamaguchi\n              K, \n            \n              Sano\n              J, \n            \n              Osada\n              S\n            \n            et al\n          . Large solitary fibrous tumor of the retroperitoneum: report of a case. Surg Today2004;34(1):90\u201393"},{"issue":"6","key":"i0020-8868-99-4-414-b03","series-title":"Eur J Cardiothorac Surg","first-page":"1087","article-title":"Solitary fibrous tumors of the pleura: clinical characteristics, surgical treatment and outcome","volume":"21","author":"Magdeleinat\n              P,","year":"2002","unstructured":"Magdeleinat\n              P, \n            \n              Alifano\n              M, \n            \n              Petino\n              A, \n            \n              Le Rochais\n              JP, \n            \n              Dulmet\n              E, \n            \n              Galateau\n              F\n            \n            et al\n          . Solitary fibrous tumors of the pleura: clinical characteristics, surgical treatment and outcome. Eur J Cardiothorac Surg2002;21(6):1087\u20131093"},{"issue":"1","key":"i0020-8868-99-4-414-b04","series-title":"Histopathology","first-page":"3","article-title":"The evolving classification of soft tissue tumours: an update based on the new WHO classification","volume":"48","author":"Fletcher\n              CD.","year":"2006","unstructured":"Fletcher\n              CD. \n          \n          The evolving classification of soft tissue tumours: an update based on the new WHO classification. Histopathology2006;48(1):3\u201312"},{"issue":"2","key":"i0020-8868-99-4-414-b05","series-title":"Semin Diagn Pathol","first-page":"169","article-title":"The spectrum of histologic growth patterns in benign and malignant fibrous tumors of the pleura","volume":"9","author":"Moran\n              CA,","year":"1992","unstructured":"Moran\n              CA, \n            \n              Suster\n              S, \n            \n              Koss\n              MN. \n          \n          The spectrum of histologic growth patterns in benign and malignant fibrous tumors of the pleura. Semin Diagn Pathol1992;9(2):169\u2013180"},{"key":"i0020-8868-99-4-414-b06","series-title":"Pathology and Genetics of Tumours of Soft Tissue and Bone","first-page":"86","article-title":"Extrapleural solitary fibrous tumour and haemangiopericytoma: World Health Organization classification of tumours","author":"Guillou\n              L,","year":"2002","unstructured":"Guillou\n              L, \n            \n              Fletcher\n              JA, \n            \n              Fletcher\n              CDM, \n            \n              Mandahl\n              N. \n          \n          Extrapleural solitary fibrous tumour and haemangiopericytoma: World Health Organization classification of tumours. In: FletcherCDM, UnniKK, MertensF, eds. Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon, France: IARC Press, 2002:86\u201390"},{"issue":"1","key":"i0020-8868-99-4-414-b07","series-title":"Histopathology","first-page":"63","article-title":"Solitary fibrous tumour and haemangiopericytoma: evolution of a concept","volume":"48","author":"Gengler\n              C,","year":"2006","unstructured":"Gengler\n              C, \n            \n              Guillou\n              L. \n          \n          Solitary fibrous tumour and haemangiopericytoma: evolution of a concept. Histopathology2006;48(1):63\u201374"},{"issue":"12","key":"i0020-8868-99-4-414-b08","series-title":"Hum Pathol","first-page":"1464","article-title":"Extrathoracic solitary fibrous tumors: their histological variability and potentially aggressive behavior","volume":"30","author":"Hasegawa\n              T,","year":"1999","unstructured":"Hasegawa\n              T, \n            \n              Matsuno\n              Y, \n            \n              Shimoda\n              T, \n            \n              Hasegawa\n              F, \n            \n              Sano\n              T, \n            \n              Hirohashi\n              S. \n          \n          Extrathoracic solitary fibrous tumors: their histological variability and potentially aggressive behavior. Hum Pathol1999;30(12):1464\u20131473"},{"issue":"8","key":"i0020-8868-99-4-414-b09","series-title":"Am J Surg Pathol","first-page":"640","article-title":"Localized benign and malignant fibrous tumors of the pleura: a clinicopathologic review of 223 cases","volume":"13","author":"England\n              DM,","year":"1989","unstructured":"England\n              DM, \n            \n              Hochholzer\n              L, \n            \n              McCarthy\n              MJ. \n          \n          Localized benign and malignant fibrous tumors of the pleura: a clinicopathologic review of 223 cases. Am J Surg Pathol1989;13(8):640\u2013658"},{"issue":"5","key":"i0020-8868-99-4-414-b10","series-title":"Pathol Int","first-page":"284","article-title":"and Ki-67 proteins useful for immunohistological diagnostic evaluations in malignant solitary fibrous tumor","volume":"53","author":"Sun\n              Y,","year":"2003","unstructured":"Sun\n              Y, \n            \n              Naito\n              Z, \n            \n              Ishiwata\n              T, \n            \n              Maeda\n              S, \n            \n              Sugisaki\n              Y, \n            \n              Asano\n              G. \n            \n              Basic\n              FGF\n            \n          \n          and Ki-67 proteins useful for immunohistological diagnostic evaluations in malignant solitary fibrous tumor. Pathol Int2003;53(5):284\u2013290"},{"issue":"5","key":"i0020-8868-99-4-414-b11","series-title":"J Clin Oncol","first-page":"1679","article-title":"Analysis of prognostic factors in 1,041 patients with localized soft tissue sarcomas of the extremities","volume":"14","author":"Pisters\n              PW,","year":"1996","unstructured":"Pisters\n              PW, \n            \n              Leung\n              DH, \n            \n              Woodruff\n              J, \n            \n              Shi\n              W, \n            \n              Brennan\n              MF. \n          \n          Analysis of prognostic factors in 1,041 patients with localized soft tissue sarcomas of the extremities. J Clin Oncol1996;14(5):1679\u20131689"},{"issue":"7","key":"i0020-8868-99-4-414-b12","series-title":"Ann Oncol","first-page":"vii92","article-title":"Soft tissue and visceral sarcomas: ESMO clinical practice guidelines for diagnosis, treatment and follow-up","volume":"23","year":"2012","unstructured":"European Sarcoma Network Working Group. Soft tissue and visceral sarcomas: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol2012;23(7):vii92\u201399."},{"issue":"1","key":"i0020-8868-99-4-414-b13","series-title":"J Clin Oncol","first-page":"31","article-title":"Primary retroperitoneal sarcomas: a multivariate analysis of surgical factors associated with local control","volume":"27","author":"Bonvalot\n              S,","year":"2009","unstructured":"Bonvalot\n              S, \n            \n              Rivoire\n              M, \n            \n              Castaing\n              M, \n            \n              Stoeckle\n              E, \n            \n              Le Cesne\n              A, \n            \n              Blay\n              JY\n            \n            et al\n          . Primary retroperitoneal sarcomas: a multivariate analysis of surgical factors associated with local control. J Clin Oncol2009;27(1):31\u201337"},{"issue":"3","key":"i0020-8868-99-4-414-b14","series-title":"Cancer","first-page":"573","article-title":"A systematic meta-analysis of randomized controlled trials of adjuvant chemotherapy for localized resectable soft-tissue sarcoma","volume":"113","author":"Pervaiz\n              N,","year":"2008","unstructured":"Pervaiz\n              N, \n            \n              Colterjohn\n              N, \n            \n              Farrokhyar\n              F. \n          \n          A systematic meta-analysis of randomized controlled trials of adjuvant chemotherapy for localized resectable soft-tissue sarcoma. Cancer2008;113(3):573\u2013581"},{"issue":"1","key":"i0020-8868-99-4-414-b15","series-title":"Curr Treat Options Oncol","first-page":"21","article-title":"Treating soft tissue sarcomas with adjuvant chemotherapy","volume":"12","author":"Patrikidou\n              A,","year":"2011","unstructured":"Patrikidou\n              A, \n            \n              Domont\n              J, \n            \n              Cioffi\n              A, \n            \n              Le Cesne\n              A. \n          \n          Treating soft tissue sarcomas with adjuvant chemotherapy. Curr Treat Options Oncol2011;12(1):21\u201331"}],"container-title":["International Surgery"],"original-title":[],"link":[{"URL":"https:\/\/international-surgery.kglmeridian.com\/view\/journals\/insu\/99\/4\/article-p414.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/international-surgery\/article-pdf\/99\/4\/414\/2218917\/intsurg-d-13-00087_1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/international-surgery.kglmeridian.com\/downloadpdf\/journals\/insu\/99\/4\/article-p414.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/international-surgery.kglmeridian.com\/downloadpdf\/journals\/insu\/99\/4\/article-p414.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T19:09:18Z","timestamp":1751483358000},"score":1,"resource":{"primary":{"URL":"https:\/\/international-surgery.kglmeridian.com\/view\/journals\/insu\/99\/4\/article-p414.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":15,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.9738\/intsurg-d-13-00087.1","relation":{},"ISSN":["0020-8868","2520-2456"],"issn-type":[{"type":"print","value":"0020-8868"},{"type":"electronic","value":"2520-2456"}],"subject":[],"published":{"date-parts":[[2014]]}}}