{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T12:38:10Z","timestamp":1789821490518,"version":"4.0.1"},"reference-count":22,"publisher":"International College of Surgeons","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:title>Abstract<\/jats:title>\n        <jats:p>The aim of this study was to analyze the association of potential risk factors such as positive family cleft history, smoking, use of drugs during pregnancy, and parental age with oral clefts in offspring within the Kosovo population. We conducted a population-based case-control study of live births in Kosovo from 1996 to 2005. Using a logistic regression model, 244 oral cleft cases were compared with 488 controls. We have excluded all syndromic clefts. Heredity increases the risk of clefts in newborns [odds ratio (OR) = 8.25, 95% confidence interval (CI) 3.12\u201323.52]. Clefts were also associated with smoking (OR = 1.87, 95% CI 0.75\u20134.08), use of drugs during pregnancy (OR = 2.25, 95% CI 0.82\u20135.12), increasing maternal age (OR = 1.83, 95% CI 1.42\u20132.49), and increasing paternal age (OR = 1.3, 95% CI 1.2\u2013 1.4). We found heredity to be the most important factor for cleft occurrence in Kosovar newborns. Another significant potential risk factor for occurrence of clefts is the parental age. We found the use of drugs and smoking during pregnancy to be less significant.<\/jats:p>","DOI":"10.9738\/intsurg-d-13-00089.1","type":"journal-article","created":{"date-parts":[[2014,3,26]],"date-time":"2014-03-26T20:44:34Z","timestamp":1395866674000},"page":"161-165","source":"Crossref","is-referenced-by-count":11,"title":["Analysis of Potential Oral Cleft Risk Factors in the Kosovo Population"],"prefix":"10.9738","volume":"99","author":[{"given":"Sami","family":"Salihu","sequence":"first","affiliation":[{"name":"Clinic of Maxillofacial Surgery, University Clinical Center of Kosovo, Pristina, Kosovo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blerim","family":"Krasniqi","sequence":"additional","affiliation":[{"name":"Royal University Iliria, Faculty of Medical Sciences Rezonanca, Pristina, Kosovo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osman","family":"Sejfija","sequence":"additional","affiliation":[{"name":"Clinic of Maxillofacial Surgery, University Clinical Center of Kosovo, Pristina, Kosovo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nijazi","family":"Heta","sequence":"additional","affiliation":[{"name":"Clinic of Maxillofacial Surgery, University Clinical Center of Kosovo, Pristina, Kosovo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nderim","family":"Salihaj","sequence":"additional","affiliation":[{"name":"General practitioner, Pristina, Kosovo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agreta","family":"Geci","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Reanimation, University Clinical Center of Kosovo, Pristina, Kosovo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milaim","family":"Sejdini","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University Clinical Center of Stomatology of Kosovo, Pristina, Kosovo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hysni","family":"Arifi","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, University Clinical Center of Kosovo, Pristina, Kosovo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramazan","family":"Isufi","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery, University of Tirana, Tirana, Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett A.","family":"Ueeck","sequence":"additional","affiliation":[{"name":"Shriners Hospital for Children, Cleft Lip Palate Clinic, Portland, Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4721","reference":[{"issue":"2","key":"i0020-8868-99-2-161-b01","series-title":"Semin Orthod","first-page":"103","article-title":"Genetic factors and orofacial clefting","volume":"14","author":"Lidral\n              AC,","year":"2008","unstructured":"Lidral\n              AC, \n            \n              Moreno\n              LM, \n            \n              Bullard\n              SA. \n          \n          Genetic factors and orofacial clefting. 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Braz Oral Res2009;23(1):31\u201337"},{"issue":"10","key":"i0020-8868-99-2-161-b05","series-title":"Int J Pediatr Otorhinolaryngol","first-page":"1434","article-title":"Impact and risk factors of craniofacial malformations in a Colombian population","volume":"73","author":"Zarante\n              I,","year":"2009","unstructured":"Zarante\n              I, \n            \n              L\u00f3pez\n              MA, \n            \n              Caro\n              A, \n            \n              Garc\u00eda-Reyes\n              JC, \n            \n              Ospina\n              JC. \n          \n          Impact and risk factors of craniofacial malformations in a Colombian population. Int J Pediatr Otorhinolaryngol2009;73(10):1434\u20131437"},{"issue":"1","key":"i0020-8868-99-2-161-b06","series-title":"J Korean Med Sci","first-page":"49","article-title":"Woo Jung K, Changhyun O, Jae-Chan K. 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