{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T12:13:25Z","timestamp":1777637605147,"version":"3.51.4"},"reference-count":19,"publisher":"International College of Surgeons","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:title>Abstract<\/jats:title>\n        <jats:p>Inflammatory pseudotumor (IPT) of the liver is rare, and differential diagnosis from malignant tumors is difficult. We herein report a case of IPT of the liver with marked elevation of carbohydrate antigen 19-9 (CA19-9). A 72-year-old woman, who underwent low anterior resection for rectal cancer, had low-grade fever and epigastric pain. The patient has well-controlled idiopathic thrombocytopenic purpura (ITP) with steroid maintenance treatment. Abnormal laboratory findings included serum carcinoembryonic antigen of 15.9 ng\/mL and CA19-9 up to 14,632 U\/mL. Computed tomography revealed a low-density lesion, and magnetic resonance imaging demonstrated a high intensity lesion on T1, T2-weighted, and diffusion-weighted images (55 \u00d7 22 mm in the Couinaud's segment 4 of the liver). However, 1 month after the appearance of the symptom, serum level of CA19-9 suddenly decreased to 37 U\/mL. The tumor decreased spontaneously to 20 \u00d7 10 mm. Seven months later, the tumor had reduced to 18 \u00d7 11 mm. With a diagnosis of IPT, the patient remains well without regrowth of the tumor at 1 year follow-up after CA19-9 decrease to normal limits.<\/jats:p>","DOI":"10.9738\/intsurg-d-13-00091.1","type":"journal-article","created":{"date-parts":[[2013,11,14]],"date-time":"2013-11-14T15:04:38Z","timestamp":1384441478000},"page":"324-329","source":"Crossref","is-referenced-by-count":13,"title":["Hepatic Inflammatory Pseudotumor With Elevated Serum CA19-9 Level Mimicking Liver Metastasis From Rectal Cancer: Report of a Case"],"prefix":"10.9738","volume":"98","author":[{"given":"Yoshihiro","family":"Shirai","sequence":"first","affiliation":[{"name":"Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Shiba","sequence":"additional","affiliation":[{"name":"Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Eto","sequence":"additional","affiliation":[{"name":"Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeyuki","family":"Misawa","sequence":"additional","affiliation":[{"name":"Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiko","family":"Yanaga","sequence":"additional","affiliation":[{"name":"Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4721","reference":[{"issue":"7","key":"i0020-8868-98-4-324-b01","series-title":"Cancer","first-page":"1583","article-title":"Inflammatory pseudotumor of the liver: clinicopathologic study and review of the literature","volume":"65","author":"Horiuchi\n              R,","year":"1990","unstructured":"Horiuchi\n              R, \n            \n              Uchida\n              T, \n            \n              Kojima\n              T, \n            \n              Shikata\n              T. \n          \n          Inflammatory pseudotumor of the liver: clinicopathologic study and review of the literature. Cancer1990;65(7):1583\u20131590"},{"issue":"2","key":"i0020-8868-98-4-324-b02","series-title":"Ann Surg","first-page":"253","article-title":"Total right hepatic lobectomy: report of a case","volume":"138","author":"Pack\n              GT,","year":"1953","unstructured":"Pack\n              GT, \n            \n              Backer\n              HW. \n          \n          Total right hepatic lobectomy: report of a case. Ann Surg1953;138(2):253\u2013258"},{"issue":"2","key":"i0020-8868-98-4-324-b03","series-title":"Am J Clin Pathol","first-page":"176","article-title":"Inflammatory pseudotumor of liver with occlusive phlebitis: report of a case in a child and review of the literature","volume":"69","author":"Someren\n              A.","year":"1978","unstructured":"Someren\n              A. \n          \n          Inflammatory pseudotumor of liver with occlusive phlebitis: report of a case in a child and review of the literature. Am J Clin Pathol1978;69(2):176\u2013181"},{"issue":"2","key":"i0020-8868-98-4-324-b04","series-title":"Am J Gastroenterol","first-page":"214","article-title":"Spontaneous regression of hepatic pseudotumor","volume":"87","author":"Gollapudi\n              P,","year":"1992","unstructured":"Gollapudi\n              P, \n            \n              Chejfec\n              G, \n            \n              Zarling\n              EJ. \n          \n          Spontaneous regression of hepatic pseudotumor. Am J Gastroenterol1992;87(2):214\u2013217"},{"issue":"4","key":"i0020-8868-98-4-324-b05","series-title":"Eur J Surg Oncol","first-page":"384","article-title":"Inflammatory pseudotumor of the liver","volume":"19","author":"Karatsis\n              P,","year":"1993","unstructured":"Karatsis\n              P, \n            \n              Wyman\n              A, \n            \n              Sweetland\n              HM, \n            \n              Bull\n              AD, \n            \n              Rogers\n              K. \n          \n          Inflammatory pseudotumor of the liver. Eur J Surg Oncol1993;19(4):384\u2013387"},{"issue":"2","key":"i0020-8868-98-4-324-b06","series-title":"Am J Roentgenol","first-page":"485","article-title":"Inflammatory pseudotumor of the liver: CT and sonographic findings","volume":"167","author":"Nam\n              KJ,","year":"1996","unstructured":"Nam\n              KJ, \n            \n              Kang\n              HK, \n            \n              Lim\n              JH. \n          \n          Inflammatory pseudotumor of the liver: CT and sonographic findings. Am J Roentgenol1996;167(2):485\u2013487"},{"issue":"3","key":"i0020-8868-98-4-324-b07","series-title":"J Gastrointest Surg","first-page":"398","article-title":"Intrahepatic cholangiocarcinoma mimicking hepatic inflammatory pseudotumor","volume":"11","author":"Kitajima\n              K,","year":"2007","unstructured":"Kitajima\n              K, \n            \n              Shiba\n              H, \n            \n              Nojiri\n              T, \n            \n              Uwgawa\n              T, \n            \n              Ishida\n              Y, \n            \n              Yanaga\n              K. \n          \n          Intrahepatic cholangiocarcinoma mimicking hepatic inflammatory pseudotumor. J Gastrointest Surg2007;11(3):398\u2013402"},{"issue":"9","key":"i0020-8868-98-4-324-b08","series-title":"Am J Gastroenterol","first-page":"1538","article-title":"Inflammatory pseudotumor of the liver: a rare entity and a diagnostic challenge","volume":"93","author":"Zamir\n              D,","year":"1998","unstructured":"Zamir\n              D, \n            \n              Jarchowsky\n              J, \n            \n              Singer\n              C, \n            \n              Abumoch\n              S, \n            \n              Groisman\n              G, \n            \n              Ammer\n              M. \n          \n          Inflammatory pseudotumor of the liver: a rare entity and a diagnostic challenge. Am J Gastroenterol1998;93(9):1538\u20131540"},{"issue":"1","key":"i0020-8868-98-4-324-b09","series-title":"Radiology","first-page":"253","article-title":"Complications of percutaneous abdominal fine needle biopsy","volume":"178","author":"Smith\n              EH.","year":"1991","unstructured":"Smith\n              EH. \n          \n          Complications of percutaneous abdominal fine needle biopsy. Radiology1991;178(1):253\u2013258"},{"issue":"4490","key":"i0020-8868-98-4-324-b10","series-title":"Science","first-page":"53","article-title":"Specific antigen serum of patient with colon carcinoma","volume":"212","author":"Koprowski\n              H,","year":"1981","unstructured":"Koprowski\n              H, \n            \n              Herlyn\n              M, \n            \n              Steplewski\n              Z, \n            \n              Sears\n              HF. \n          \n          Specific antigen serum of patient with colon carcinoma. Science1981;212(4490):53\u201355"},{"issue":"2","key":"i0020-8868-98-4-324-b11","series-title":"Hybridoma","first-page":"219","article-title":"Distribution of monoclonal antibody-defined monosialoganglioside in normal and cancerous human tissue: an immunoperoxidase study","volume":"2","author":"Arends\n              JW,","year":"1983","unstructured":"Arends\n              JW, \n            \n              Verstynen\n              C, \n            \n              Bosman\n              FT, \n            \n              Hilgers\n              J, \n            \n              Steplewski\n              Z. \n          \n          Distribution of monoclonal antibody-defined monosialoganglioside in normal and cancerous human tissue: an immunoperoxidase study. Hybridoma1983;2(2):219\u2013229"},{"issue":"4","key":"i0020-8868-98-4-324-b12","series-title":"Am J Gastroenterol","first-page":"350","article-title":"The clinical utility of the CA19-9 tumor-associated antigen","volume":"85","author":"Steinberg\n              WM.","year":"1990","unstructured":"Steinberg\n              WM. \n          \n          The clinical utility of the CA19-9 tumor-associated antigen. 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J Hepatobiliary Pancreat Surg2007;14(6):539\u2013544"},{"issue":"4","key":"i0020-8868-98-4-324-b14","series-title":"Intern Med","first-page":"516","article-title":"A case of common bile duct stone with cholangitis presenting an extraordinary high serum CA19-9 value","volume":"31","author":"Murohisa\n              T,","year":"1992","unstructured":"Murohisa\n              T, \n            \n              Sugaya\n              H, \n            \n              Testuka\n              I, \n            \n              Suzuki\n              T, \n            \n              Harada\n              T. \n          \n          A case of common bile duct stone with cholangitis presenting an extraordinary high serum CA19-9 value. Intern Med1992;31(4):516\u2013520"},{"issue":"2","key":"i0020-8868-98-4-324-b15","series-title":"Radiology","first-page":"373","article-title":"Inflammatory pseudotumor of the liver in patients with recurrent pyogenic cholangitis: CT-histopathologic correlation","volume":"211","author":"Yoon\n              KH,","year":"1999","unstructured":"Yoon\n              KH, \n            \n              Ha\n              HK, \n            \n              Lee\n              JS, \n            \n              Suh\n              JH, \n            \n              Kim\n              MH, \n            \n              Kim\n              PN\n            \n            et al\n          . Inflammatory pseudotumor of the liver in patients with recurrent pyogenic cholangitis: CT-histopathologic correlation. Radiology1999;211(2):373\u2013379"},{"issue":"11","key":"i0020-8868-98-4-324-b16","series-title":"Dig Dis Sci","first-page":"3140","article-title":"Extremely elevated CA19-9 in acute cholangitis","volume":"52","author":"Sheen-Chen\n              SM,","year":"2007","unstructured":"Sheen-Chen\n              SM, \n            \n              Sun\n              CK, \n            \n              Liu\n              YW, \n            \n              Eng\n              HL, \n            \n              Ko\n              SF, \n            \n              Kuo\n              CH. \n          \n          Extremely elevated CA19-9 in acute cholangitis. Dig Dis Sci2007;52(11):3140\u20133142"},{"issue":"2","key":"i0020-8868-98-4-324-b17","series-title":"J Am Coll Surg","first-page":"226","article-title":"Inflammatory pseudotumor of the liver: demographics, diagnosis, and the case for nonoperative management","volume":"196","author":"Koea\n              JB,","year":"2003","unstructured":"Koea\n              JB, \n            \n              Broadhurst\n              GW, \n            \n              Rodgers\n              MS, \n            \n              McCall\n              JL. \n          \n          Inflammatory pseudotumor of the liver: demographics, diagnosis, and the case for nonoperative management. J Am Coll Surg2003;196(2):226\u2013235"},{"issue":"2","key":"i0020-8868-98-4-324-b18","series-title":"Am J Gastroenterol","first-page":"529","article-title":"Inflammatory pseudotumor of the liver and pregnancy","volume":"94","author":"Maze\n              GL,","year":"1999","unstructured":"Maze\n              GL, \n            \n              Lee\n              M, \n            \n              Schenker\n              S. \n          \n          Inflammatory pseudotumor of the liver and pregnancy. Am J Gastroenterol1999;94(2):529\u2013530"},{"issue":"6","key":"i0020-8868-98-4-324-b19","series-title":"Surgery","first-page":"839","article-title":"Inflammatory lesions of the liver which simulate tumor: report of two cases in children","volume":"69","author":"Hertzer\n              NR,","year":"1971","unstructured":"Hertzer\n              NR, \n            \n              Hawk\n              WA, \n            \n              Herman\n              RE. \n          \n          Inflammatory lesions of the liver which simulate tumor: report of two cases in children. 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