{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T02:07:01Z","timestamp":1792548421352,"version":"4.5.0"},"reference-count":26,"publisher":"International College of Surgeons","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:title>Abstract<\/jats:title>\n        <jats:p>The objective of this study was to analyze the clinical benefit of histopathologic analysis of appendectomy specimens from patients with an initial diagnosis of acute appendicitis. We retrospectively analyzed the demographic and histopathologic data of 1255 patients (712 males, 543 females; age range, 17\u201385 years) who underwent appendectomy to treat an initial diagnosis of acute appendicitis. Patients who underwent incidental appendectomy during other surgeries were excluded from the study. Histopathologic findings of the appendectomy specimens were used to confirm the initial diagnosis. Ninety-four percent of the appendectomy specimens were positive for appendicitis. Of those, 880 were phlegmonous appendicitis, 148 were gangrenous appendicitis with perforation, and the remaining 88 showed unusual histopathologic findings. In the 88 specimens with unusual pathology, fibrous obliteration was observed in 57 specimens, carcinoid tumor in 11, <jats:italic>Encheliophis vermicularis<\/jats:italic> parasite infection in 8, granulatomous inflammation in 6, appendiceal endometriosis in 2, and 1 specimen each showed mucocele, eosinophilic infiltration, <jats:italic>Taenia saginata<\/jats:italic> parasite infection, and appendicular diverticulitis. All carcinoid tumors were located in the distal appendix. Six of the 11 carcinoid tumors were defined by histopathology as involving tubular cells, and the other 5 as involving enterochromaffin cells. Six patients had muscularis propria invasion, 2 patients had submucosa invasion, 2 patients had mesoappendix invasion, and 1 patient had serosal invasion. All patients with tumors remained disease free during the follow-up (range, 1\u201327 months). We conclude that when the ratio of unusual pathologic findings for appendectomy specimens is considered, it is evident that all surgical specimens should be subjected to careful histologic examination.<\/jats:p>","DOI":"10.9738\/intsurg-d-13-00098.1","type":"journal-article","created":{"date-parts":[[2013,11,14]],"date-time":"2013-11-14T15:04:38Z","timestamp":1384441478000},"page":"354-362","source":"Crossref","is-referenced-by-count":54,"title":["Routine Histopathologic Examination of Appendectomy Specimens: Retrospective Analysis of 1255 Patients"],"prefix":"10.9738","volume":"98","author":[{"given":"Arif","family":"Emre","sequence":"first","affiliation":[{"name":"Department of Surgery, Malatya State Hospital, 44300 Malatya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Akbulut","sequence":"additional","affiliation":[{"name":"Department of Surgery, Inonu University Faculty of Medicine, 44280 Malatya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehra","family":"Bozdag","sequence":"additional","affiliation":[{"name":"Department of Pathology, Malatya State Hospital, 44300 Malatya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Surgery, Inonu University Faculty of Medicine, 44280 Malatya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Kanlioz","sequence":"additional","affiliation":[{"name":"Department of Surgery, Malatya State Hospital, 44300 Malatya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabia","family":"Emre","sequence":"additional","affiliation":[{"name":"Malatya Public Health Center, 44300 Malatya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurhan","family":"Sahin","sequence":"additional","affiliation":[{"name":"Department of Pathology, Malatya State Hospital, 44300 Malatya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4721","reference":[{"issue":"15","key":"i0020-8868-98-4-354-b01","series-title":"World J Gastroenterol","first-page":"1961","article-title":"Unusual histopathological findings in appendectomy specimens: a retrospective analysis and literature review","volume":"17","author":"Akbulut\n              S,","year":"2011","unstructured":"Akbulut\n              S, \n            \n              Tas\n              M, \n            \n              Sogutcu\n              N, \n            \n              Arikanoglu\n              Z, \n            \n              Basbug\n              M, \n            \n              Ulku\n              A. \n          \n          Unusual histopathological findings in appendectomy specimens: a retrospective analysis and literature review. World J Gastroenterol2011;17(15):1961\u20131970"},{"issue":"3","key":"i0020-8868-98-4-354-b02","series-title":"Surg Endosc","first-page":"849","article-title":"Histological characterization of appendectomy specimens with intraoperative appearance of vascular injection","volume":"27","author":"Zdichavsky\n              M,","year":"2013","unstructured":"Zdichavsky\n              M, \n            \n              G\u00f6gele\n              H, \n            \n              Blank\n              G, \n            \n              Kraulich\n              M, \n            \n              Meile\n              T, \n            \n              von Feilitzsch\n              M. \n          \n          Histological characterization of appendectomy specimens with intraoperative appearance of vascular injection. Surg Endosc2013;27(3):849\u2013853"},{"issue":"11","key":"i0020-8868-98-4-354-b03","series-title":"ANZ J Surg","first-page":"844","article-title":"Pathologies of the appendix: a 10-year review of 4670 appendicectomy specimens","volume":"82","author":"Chandrasegaram\n              MD,","year":"2012","unstructured":"Chandrasegaram\n              MD, \n            \n              Rothwell\n              LA, \n            \n              An\n              EI, \n            \n              Miller\n              RJ. \n          \n          Pathologies of the appendix: a 10-year review of 4670 appendicectomy specimens. ANZ J Surg2012;82(11):844\u2013847"},{"issue":"8","key":"i0020-8868-98-4-354-b04","series-title":"J Gastroenterol","first-page":"745","article-title":"Review of the pathological results of 2660 appendicectomy specimens","volume":"41","author":"Marudanayagam\n              R,","year":"2006","unstructured":"Marudanayagam\n              R, \n            \n              Williams\n              GT, \n            \n              Rees\n              BI. \n          \n          Review of the pathological results of 2660 appendicectomy specimens. J Gastroenterol2006;41(8):745\u2013749"},{"issue":"11","key":"i0020-8868-98-4-354-b05","series-title":"Colorectal Dis","first-page":"1214","article-title":"Is routine histopathological examination of appendectomy specimens useful? A systematic review of the literature","volume":"13","author":"Swank\n              HA,","year":"2011","unstructured":"Swank\n              HA, \n            \n              Eshuis\n              EJ, \n            \n              Ubbink\n              DT, \n            \n              Bemelman\n              WA. \n          \n          Is routine histopathological examination of appendectomy specimens useful? A systematic review of the literature. Colorectal Dis2011;13(11):1214\u20131221"},{"issue":"4","key":"i0020-8868-98-4-354-b06","series-title":"Indian J Surg","first-page":"221","article-title":"Unusual findings in appendicectomy specimens: evaluation of 2458 cases and review of the literature","volume":"66","author":"Duzgun\n              AP,","year":"2004","unstructured":"Duzgun\n              AP, \n            \n              Moran\n              M, \n            \n              Uzun\n              S, \n            \n              Ozmen\n              MM, \n            \n              Ozer\n              VM, \n            \n              Seckin\n              S. \n          \n          Unusual findings in appendicectomy specimens: evaluation of 2458 cases and review of the literature. Indian J Surg2004;66(4):221\u2013226"},{"issue":"1","key":"i0020-8868-98-4-354-b07","series-title":"Int J Surg Pathol","first-page":"14","article-title":"Granulomatous diseases and granulomas of the appendix","volume":"18","author":"AbdullGaffar\n              B.","year":"2010","unstructured":"AbdullGaffar\n              B. \n          \n          Granulomatous diseases and granulomas of the appendix. Int J Surg Pathol2010;18(1):14\u201320"},{"issue":"2","key":"i0020-8868-98-4-354-b08","series-title":"Indian J Pathol Microbiol","first-page":"258","article-title":"Acute eosinophilic appendicitis and the significance of eosinophil-edema lesion","volume":"53","author":"Aravindan\n              KP,","year":"2010","unstructured":"Aravindan\n              KP, \n            \n              Vijayaraghavan\n              D, \n            \n              Manipadam\n              MT. \n          \n          Acute eosinophilic appendicitis and the significance of eosinophil-edema lesion. Indian J Pathol Microbiol2010;53(2):258\u2013261"},{"issue":"11","key":"i0020-8868-98-4-354-b09","series-title":"Rev Esp Enferm Dig","first-page":"582","article-title":"Appendicular pseudodiverticula and acute appendicitis. Our 12-year experience","volume":"103","year":"2011","unstructured":"Manzanares-Campillo Mdel C, Pardo-Garc\u00eda R, Mart\u00edn-Fern\u00e1ndez J. Appendicular pseudodiverticula and acute appendicitis. Our 12-year experience. Rev Esp Enferm Dig2011;103(11):582\u2013585"},{"issue":"3","key":"i0020-8868-98-4-354-b10","series-title":"Int Surg","first-page":"266","article-title":"Mucocele of the appendix: case report and review of literature","volume":"97","author":"Demetrashvili\n              Z,","year":"2012","unstructured":"Demetrashvili\n              Z, \n            \n              Chkhaidze\n              M, \n            \n              Khutsishvili\n              K, \n            \n              Topchishvili\n              G, \n            \n              Javakhishvili\n              T, \n            \n              Pipia\n              I. \n          \n          Mucocele of the appendix: case report and review of literature. Int Surg2012;97(3):266\u2013269"},{"issue":"4","key":"i0020-8868-98-4-354-b11","series-title":"Trop Gastroenterol","first-page":"332","article-title":"Appendiceal neuroma: report of an elusive neuroma","volume":"32","author":"Gupta\n              K,","year":"2011","unstructured":"Gupta\n              K, \n            \n              Solanki\n              A, \n            \n              Vasishta\n              RK. \n          \n          Appendiceal neuroma: report of an elusive neuroma. Trop Gastroenterol2011;32(4):332\u2013333"},{"issue":"7","key":"i0020-8868-98-4-354-b12","series-title":"Inflamm Bowel Dis","first-page":"1093","article-title":"Crohn's disease patient with right lower quadrant abdominal pain for 20 years due to an appendiceal neuroma (fibrous obliteration of the appendix)","volume":"16","author":"Patel\n              AV,","year":"2010","unstructured":"Patel\n              AV, \n            \n              Friedman\n              M, \n            \n              MacDermott\n              RP. \n          \n          Crohn's disease patient with right lower quadrant abdominal pain for 20 years due to an appendiceal neuroma (fibrous obliteration of the appendix). Inflamm Bowel Dis2010;16(7):1093\u20131094"},{"issue":"6","key":"i0020-8868-98-4-354-b13","series-title":"Am J Surg","first-page":"805","article-title":"Appendiceal carcinoid at a large tertiary center: pathologic findings and long-term follow-up evaluation","volume":"201","author":"Shapiro\n              R,","year":"2011","unstructured":"Shapiro\n              R, \n            \n              Eldar\n              S, \n            \n              Sadot\n              E, \n            \n              Papa\n              MZ, \n            \n              Zippel\n              DB. \n          \n          Appendiceal carcinoid at a large tertiary center: pathologic findings and long-term follow-up evaluation. Am J Surg2011;201(6):805\u2013808"},{"issue":"8","key":"i0020-8868-98-4-354-b14","series-title":"J Gastrointest Surg","first-page":"1436","article-title":"Carcinoid tumour of the appendix: an analysis of 1,485 consecutive emergency appendectomies","volume":"12","author":"In't Hof\n              KH,","year":"2008","unstructured":"In't Hof\n              KH, \n            \n              van der Wal\n              HC, \n            \n              Kazemier\n              G, \n            \n              Lange\n              JF. \n          \n          Carcinoid tumour of the appendix: an analysis of 1,485 consecutive emergency appendectomies. J Gastrointest Surg2008;12(8):1436\u20131438"},{"issue":"5","key":"i0020-8868-98-4-354-b15","series-title":"Surgeon","first-page":"286","article-title":"Granulomatous appendicitis","volume":"1","author":"Tucker\n              ON,","year":"2003","unstructured":"Tucker\n              ON, \n            \n              Healy\n              V, \n            \n              Jeffers\n              M, \n            \n              Keane\n              FB. \n          \n          Granulomatous appendicitis. Surgeon2003;1(5):286\u2013289"},{"issue":"3","key":"i0020-8868-98-4-354-b16","series-title":"Arch Gynecol Obstet","first-page":"495","article-title":"Appendiceal endometriosis presenting as perforated appendicitis: report of a case and review of the literature","volume":"280","author":"Akbulut\n              S,","year":"2009","unstructured":"Akbulut\n              S, \n            \n              Dursun\n              P, \n            \n              Kocbiyik\n              A, \n            \n              Harman\n              A, \n            \n              Sevmis\n              S. \n          \n          Appendiceal endometriosis presenting as perforated appendicitis: report of a case and review of the literature. Arch Gynecol Obstet2009;280(3):495\u2013497"},{"issue":"2","key":"i0020-8868-98-4-354-b17","series-title":"Parasitol Res","first-page":"171","article-title":"Appendiceal taeniasis presenting like acute appendicitis","volume":"97","author":"Sartorelli\n              AC,","year":"2005","unstructured":"Sartorelli\n              AC, \n            \n              da Silva\n              MG, \n            \n              Rodrigues\n              MA, \n            \n              da Silva\n              RJ. \n          \n          Appendiceal taeniasis presenting like acute appendicitis. Parasitol Res2005;97(2):171\u2013172"},{"key":"i0020-8868-98-4-354-b18","series-title":"BMC Surg","first-page":"17","article-title":"The value of routine histopathological examination of appendicectomy specimens","volume":"7","author":"Jones\n              AE,","year":"2007","unstructured":"Jones\n              AE, \n            \n              Phillips\n              AW, \n            \n              Jarvis\n              JR, \n            \n              Sargen\n              K. \n          \n          The value of routine histopathological examination of appendicectomy specimens. BMC Surg2007;7:17"},{"issue":"2","key":"i0020-8868-98-4-354-b19","series-title":"Trop Gastroenterol","first-page":"130","article-title":"Idiopathic granulomatous appendicitis: a rare appendicular pseudo tumor","volume":"31","author":"Shivakumar\n              P,","year":"2010","unstructured":"Shivakumar\n              P, \n            \n              Shanmugam\n              RP, \n            \n              Mani\n              CS. \n          \n          Idiopathic granulomatous appendicitis: a rare appendicular pseudo tumor. Trop Gastroenterol2010;31(2):130\u2013131"},{"issue":"2","key":"i0020-8868-98-4-354-b20","series-title":"JBR-BTR","first-page":"114","article-title":"Appendicular diverticulitis in an Amyand's hernia","volume":"93","author":"Coulier\n              B,","year":"2010","unstructured":"Coulier\n              B, \n            \n              Pierard\n              F, \n            \n              Malbecq\n              S. \n          \n          Appendicular diverticulitis in an Amyand's hernia. JBR-BTR2010;93(2):114"},{"issue":"1","key":"i0020-8868-98-4-354-b21","series-title":"Int J Surg Case Rep","first-page":"54","article-title":"An unusual cause of acute appendicitis: appendiceal endometriosis","volume":"4","author":"Emre\n              A,","year":"2012","unstructured":"Emre\n              A, \n            \n              Akbulut\n              S, \n            \n              Yilmaz\n              M, \n            \n              Bozdag\n              Z. \n          \n          An unusual cause of acute appendicitis: appendiceal endometriosis. Int J Surg Case Rep2012;4(1):54\u201357"},{"issue":"4","key":"i0020-8868-98-4-354-b22","series-title":"Hospital Chronicles","first-page":"207","article-title":"Taeniasis caused appendicitis without local tenderness: a rare case","volume":"6","author":"Hafezi Ahmadi\n              M,","year":"2011","unstructured":"Hafezi Ahmadi\n              M, \n            \n              Seifmanesh\n              H. \n          \n          Taeniasis caused appendicitis without local tenderness: a rare case. Hospital Chronicles2011;6(4):207\u2013209"},{"issue":"3","key":"i0020-8868-98-4-354-b23","series-title":"Saudi J Gastroenterol","first-page":"167","article-title":"Acute appendicitis: is removal of a normal appendix still existing and can we reduce its rate?","volume":"15","author":"Khairy\n              G.","year":"2009","unstructured":"Khairy\n              G. \n          \n          Acute appendicitis: is removal of a normal appendix still existing and can we reduce its rate?\n          Saudi J Gastroenterol\n          2009;15(3):167\u2013170"},{"issue":"4","key":"i0020-8868-98-4-354-b24","series-title":"Am J Surg","first-page":"433","article-title":"Negative appendectomy: a 10-year review of a nationally representative sample","volume":"201","author":"Seetahal\n              SA,","year":"2011","unstructured":"Seetahal\n              SA, \n            \n              Bolorunduro\n              OB, \n            \n              Sookdeo\n              TC, \n            \n              Oyetunji\n              TA, \n            \n              Greene\n              WR, \n            \n              Frederick\n              W. \n          \n          Negative appendectomy: a 10-year review of a nationally representative sample. Am J Surg2011;201(4):433\u2013437"},{"issue":"5","key":"i0020-8868-98-4-354-b25","series-title":"Semin Ultrasound CT MR","first-page":"293","article-title":"Imaging acute appendicitis","volume":"29","author":"Brown\n              MA.","year":"2008","unstructured":"Brown\n              MA. \n          \n          Imaging acute appendicitis. Semin Ultrasound CT MR2008;29(5):293\u2013307"},{"issue":"4","key":"i0020-8868-98-4-354-b26","series-title":"Indian J Radiol Imaging","first-page":"523","article-title":"Imaging in acute appendicitis: a review","volume":"16","author":"Jain\n              RK,","year":"2006","unstructured":"Jain\n              RK, \n            \n              Jain\n              M, \n            \n              Rajak\n              CL, \n            \n              Mukherjee\n              S, \n            \n              Bhattacharyya\n              PP, \n            \n              Shah\n              MR. \n          \n          Imaging in acute appendicitis: a review. 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