{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T03:26:23Z","timestamp":1778901983575,"version":"3.51.4"},"reference-count":10,"publisher":"International College of Surgeons","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:title>Abstract<\/jats:title>\n        <jats:p>Granular cell tumor may be located anywhere in the body; however, the gastrointestinal tract is infrequently involved and anal granular cell tumors are extremely rare. We report herein a rare case of granular cell tumor in the anal region. In the current case, a 66-year-old Japanese woman was found to have a polypoid lesion in the anus with hemorrhoids. The mass detected as an anal polypoid lesion with ulceration was resected and diagnosed as granular cell tumor by histologic examination. Granular cell tumor of the anal region is rare, and benign perianal polypoid lesions are relatively uncommon clinical findings. They might present diagnostic challenges to surgeons and pathologists. Awareness of the differential diagnosis of granular cell tumor and careful microscopic examination might allow proper management and diagnosis.<\/jats:p>","DOI":"10.9738\/intsurg-d-13-00149.1","type":"journal-article","created":{"date-parts":[[2014,1,20]],"date-time":"2014-01-20T22:47:19Z","timestamp":1390258039000},"page":"45-47","source":"Crossref","is-referenced-by-count":5,"title":["A Rare Case of Granular Cell Tumor of the Anal Region: Diagnostic Difficulty to Masses in the Anal Area"],"prefix":"10.9738","volume":"99","author":[{"given":"Takaaki","family":"Fujii","sequence":"first","affiliation":[{"name":"Department of General Surgical Science, Graduate School of Medicine, Gunma University, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of General Surgical Science, Graduate School of Medicine, Gunma University, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of General Surgical Science, Graduate School of Medicine, Gunma University, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soichi","family":"Tsutsumi","sequence":"additional","affiliation":[{"name":"Department of General Surgical Science, Graduate School of Medicine, Gunma University, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Asao","sequence":"additional","affiliation":[{"name":"Department of General Surgical Science, Graduate School of Medicine, Gunma University, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Kuwano","sequence":"additional","affiliation":[{"name":"Department of General Surgical Science, Graduate School of Medicine, Gunma University, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4721","reference":[{"issue":"2","key":"i0020-8868-99-1-45-b01","series-title":"J Cutan Pathol","first-page":"188","article-title":"Cutaneous granular cell tumor with epidermal involvement: a potential mimic of melanocytic neoplasia","volume":"34","author":"Ray\n              S,","year":"2007","unstructured":"Ray\n              S, \n            \n              Jukic\n              D. \n          \n          Cutaneous granular cell tumor with epidermal involvement: a potential mimic of melanocytic neoplasia. J Cutan Pathol2007;34(2):188\u2013194"},{"issue":"4","key":"i0020-8868-99-1-45-b02","series-title":"Adv Anat Pathol","first-page":"186","article-title":"Granular cell tumor: a review and update","volume":"6","author":"Ordonez\n              NG.","year":"1999","unstructured":"Ordonez\n              NG. \n          \n          Granular cell tumor: a review and update. Adv Anat Pathol1999;6(4):186\u2013203"},{"issue":"10","key":"i0020-8868-99-1-45-b03","series-title":"Dis Colon Rectum","first-page":"1444","article-title":"Granular cell tumor\u2014a unique neoplasm of the internal anal sphincter: report of a case","volume":"43","author":"Cohen\n              MG,","year":"2000","unstructured":"Cohen\n              MG, \n            \n              Greenwald\n              ML, \n            \n              Garbus\n              JE, \n            \n              Zager\n              JS. \n          \n          Granular cell tumor\u2014a unique neoplasm of the internal anal sphincter: report of a case. Dis Colon Rectum2000;43(10):1444\u20131446; discussion 1447"},{"issue":"4","key":"i0020-8868-99-1-45-b04","series-title":"Tumori","first-page":"538","article-title":"Perianal granular cell tumor: report of a case and review of the literature","volume":"95","author":"Mistrangelo\n              M,","year":"2009","unstructured":"Mistrangelo\n              M, \n            \n              Cassoni\n              P, \n            \n              Scozzari\n              G, \n            \n              Castellano\n              I, \n            \n              Gavello\n              G, \n            \n              Corno\n              F\n            \n            et al\n          . Perianal granular cell tumor: report of a case and review of the literature. Tumori2009;95(4):538\u2013541"},{"issue":"6","key":"i0020-8868-99-1-45-b05","series-title":"Int J Colorectal Dis","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1007\/s00384-010-1061-z","article-title":"Anal region: an unusual location of granular cell tumor","volume":"26","author":"Mourra\n              N,","year":"2011","unstructured":"Mourra\n              N, \n            \n              Werbrouck\n              A, \n            \n              Bauer\n              P. \n          \n          Anal region: an unusual location of granular cell tumor. Int J Colorectal Dis2011;26(6): 811\u2013812. DOI:10.1007\/s00384-010-1061-z"},{"issue":"4","key":"i0020-8868-99-1-45-b06","series-title":"Indian J Dermatol","doi-asserted-by":"publisher","first-page":"403","DOI":"10.4103\/0019\u20135154.74573","article-title":"Malignant granular cell tumor of the anal-perianal region and suprarenal hyperplasia: a casual association?","volume":"55","author":"Francesco\n              VD,","year":"2010","unstructured":"Francesco\n              VD, \n            \n              Avellini\n              C, \n            \n              Pappalardo\n              S, \n            \n              Proscia\n              D, \n            \n              Piccirillo\n              F. \n          \n          Malignant granular cell tumor of the anal-perianal region and suprarenal hyperplasia: a casual association?\n          Indian J Dermatol\n          2010;55(4):403\u2013405. DOI:10.4103\/0019\u20135154.74573"},{"issue":"12","key":"i0020-8868-99-1-45-b07","series-title":"Pathol Res Pract","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.prp.2012.09.004","article-title":"Benign anal and perianal polypoid neoplasms and tumor-like lesions","volume":"208","author":"Abdullgaffar\n              B,","year":"2012","unstructured":"Abdullgaffar\n              B, \n            \n              Keloth\n              T, \n            \n              Al-Hattawi\n              M, \n            \n              Marzouqi\n              MA, \n            \n              Eltayeb\n              Y. \n          \n          Benign anal and perianal polypoid neoplasms and tumor-like lesions. Pathol Res Pract2012;208(12):719\u2013725. DOI: 10.1016\/j.prp.2012.09.004"},{"key":"i0020-8868-99-1-45-b08","series-title":"Curr Opin Gen Surg","first-page":"103","article-title":"Rare anorectal pathologic conditions","author":"Denis\n              J,","year":"1994","unstructured":"Denis\n              J, \n            \n              Ganansia\n              R, \n            \n              Puy-Montbrun\n              T. \n          \n          Rare anorectal pathologic conditions. Curr Opin Gen Surg1994;103\u2013107"},{"issue":"9","key":"i0020-8868-99-1-45-b09","series-title":"Dig Dis Sci","first-page":"807","article-title":"Granular cell tumors of the gastrointestinal tract and perianal region: a study of 74 cases","volume":"26","author":"Johnston\n              J,","year":"1981","unstructured":"Johnston\n              J, \n            \n              Helwig\n              EB. \n          \n          Granular cell tumors of the gastrointestinal tract and perianal region: a study of 74 cases. Dig Dis Sci1981;26(9):807\u2013816"},{"issue":"2","key":"i0020-8868-99-1-45-b10","series-title":"Acta Cytol","first-page":"199","article-title":"Granular cell tumor of the biliary system: a report of 2 cases with cytologic diagnosis on endoscopic brushing","volume":"49","author":"Hoda\n              RS,","year":"2005","unstructured":"Hoda\n              RS, \n            \n              Minamiguchi\n              S, \n            \n              Lewin\n              DN, \n            \n              Foody\n              W, \n            \n              Weselow\n              G, \n            \n              Wildi\n              SM. \n          \n          Granular cell tumor of the biliary system: a report of 2 cases with cytologic diagnosis on endoscopic brushing. 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